Invention Grant
- Patent Title: Method of stimulating an immune response using a pseudotyped lentivirus
- Patent Title (中): 使用假型慢病毒刺激免疫应答的方法
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Application No.: US14532371Application Date: 2014-11-04
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Publication No.: US09303072B2Publication Date: 2016-04-05
- Inventor: Pin Wang , Lili Yang , David Baltimore
- Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Applicant Address: US CA Pasadena
- Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee Address: US CA Pasadena
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A01N63/00
- IPC: A01N63/00 ; C07K14/005 ; A61K31/70 ; A61K38/17 ; A61K38/19 ; A61K38/20 ; A61K35/76 ; C12N15/86 ; A61K39/21 ; C12N7/00 ; A61K39/00
Abstract:
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
Public/Granted literature
- US20150175667A1 TARGETED GENE DELIVERY FOR DENDRITIC CELL VACCINATION Public/Granted day:2015-06-25
Information query
