Invention Grant
US09315472B2 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
有权
1,3,5-三氮杂环戊烷-2,4,6-三酮衍生物及其用途
- Patent Title: 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
- Patent Title (中): 1,3,5-三氮杂环戊烷-2,4,6-三酮衍生物及其用途
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Application No.: US14267530Application Date: 2014-05-01
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Publication No.: US09315472B2Publication Date: 2016-04-19
- Inventor: Yizhou Dong , Akinleye C. Alabi , Hao Yin , Joseph R. Dorkin , Delai Chen , Robert S. Langer , Daniel Griffith Anderson , Ahmed A. Eltoukhy
- Applicant: Massachusetts Institute of Technology
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07D251/30
- IPC: C07D251/30 ; A61K31/53 ; A61K31/713
Abstract:
The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.
Public/Granted literature
- US20140329884A1 1,3,5-TRIAZINANE-2,4,6-TRIONE DERIVATIVES AND USES THEREOF Public/Granted day:2014-11-06
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