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公开(公告)号：US11458158B2
公开(公告)日：2022-10-04
申请号：US16867291
申请日：2020-05-05
发明人： Yizhou Dong , Kevin Thomas Love , Robert S. Langer , Daniel Griffith Anderson , Delai Chen , Yi Chen , Arturo Jose Vegas , Akinleye C. Alabi , Yunlong Zhang
IPC分类号： A61K31/7105 , C07D233/64 , C07D403/06 , C07D241/08 , C07C229/12 , C07C229/22 , C07C229/26 , C07D487/06 , C07D207/16 , C07D209/20 , C07C271/22 , C07C229/36 , C07C237/08 , C07C237/12 , C12N15/88 , C12N15/87 , C07C229/24 , C07C279/14 , C07C323/58 , C07D209/24 , C07D265/32 , C07D413/06 , C07D487/04 , C12Q1/02 , G01N33/15 , A61K31/711 , A61K47/22
摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
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公开(公告)号：US20210101875A1
公开(公告)日：2021-04-08
申请号：US17070486
申请日：2020-10-14
发明人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： C07D295/13 , A61K9/127 , A61K9/51 , A61K47/16 , A61K48/00 , C07C215/14 , C12N15/11 , C12N15/88 , A61K47/54 , C07C217/08 , A61K31/7088 , A61K38/02 , A61K9/107 , C12N15/113
摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
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公开(公告)号：US10683379B2
公开(公告)日：2020-06-16
申请号：US15078685
申请日：2016-03-23
发明人： Daniel Griffith Anderson , Eric Andrew Appel , Yizhou Dong , Robert S. Langer , Benjamin C. Tang , Omid Veiseh , Weiheng Wang , Matthew J. Webber , Kun Xue
IPC分类号： C08F8/12 , C08F8/28 , A61K47/32 , C08F120/56 , C08F120/60 , C08F130/06 , C08F220/56 , C08F220/60 , C08F230/06
摘要： Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.
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公开(公告)号：US20190240349A1
公开(公告)日：2019-08-08
申请号：US16268902
申请日：2019-02-06
发明人： Daniel Griffith Anderson , Joseph R. Dorkin , Owen Shea Fenton , Kevin John Kauffman , Rebecca L. McClellan
IPC分类号： A61K48/00 , A61K47/54 , A61K38/18 , C07D241/08
摘要： Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
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公开(公告)号：US10201618B2
公开(公告)日：2019-02-12
申请号：US15186361
申请日：2016-06-17
发明人： Daniel Griffith Anderson , Joseph R. Dorkin , Owen Shea Fenton , Kevin John Kauffman , Rebecca L. McClellan
摘要： Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
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公开(公告)号：US20180296733A1
公开(公告)日：2018-10-18
申请号：US15988753
申请日：2018-05-24
发明人： Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
IPC分类号： A61L29/16
摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(=0)-0-]n, R (I) [H2C═CR′—C(=0)-NH—]n R (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
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公开(公告)号：US10086013B2
公开(公告)日：2018-10-02
申请号：US15340082
申请日：2016-11-01
发明人： Yizhou Dong , Kevin Thomas Love , Robert S. Langer , Daniel Griffith Anderson , Delai Chen , Yi Chen , Arturo Jose Vegas , Akinleye C. Alabi , Yunlong Zhang
IPC分类号： A61K31/535 , A61K31/7105 , A61K31/711 , C07D241/08 , A61K47/22
摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
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公开(公告)号：US20180036333A9
公开(公告)日：2018-02-08
申请号：US15340082
申请日：2016-11-01
发明人： Yizhou Dong , Kevin Thomas Love , Robert S. Langer , Daniel Griffith Anderson , Delai Chen , Yi Chen , Arturo Jose Vegas , Akinleye C. Alabi , Yunlong Zhang
IPC分类号： A61K31/7105 , A61K47/22 , C07D241/08 , A61K31/711
CPC分类号： A61K31/7105 , A61K31/711 , A61K47/22 , A61K2121/00 , C07C229/12 , C07C229/22 , C07C229/24 , C07C229/26 , C07C229/36 , C07C237/08 , C07C237/12 , C07C271/22 , C07C279/14 , C07C323/58 , C07D207/16 , C07D209/20 , C07D209/24 , C07D233/64 , C07D241/08 , C07D265/32 , C07D403/06 , C07D413/06 , C07D487/04 , C07D487/06 , C12N15/87 , C12N15/88 , C12Q1/025 , G01N33/15
摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
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公开(公告)号：US09840479B2
公开(公告)日：2017-12-12
申请号：US14789227
申请日：2015-07-01
IPC分类号： A61K31/495 , C07D241/08 , C07C219/06 , C07C219/08 , C07D295/088
CPC分类号： C07D241/08 , C07C219/06 , C07C219/08 , C07D295/088
摘要： The present disclosure provides polyamine-fatty acid derived lipidoids (e.g., compounds of Formula (I) or (II)) and methods of preparing the lipidoids. A described lipidoid includes R—C(═O)—O— moieties (where R is a lipid moiety), which may be hydrolyzed into non-toxic fatty acids. Also provided are compositions including a described lipidoid and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that involve the lipidoids or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, and metabolic disorders.
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10.发明授权Amino acid-, peptide-and polypeptide-lipids, isomers, compositions, and uses thereof 有权氨基酸，肽和多肽 - 脂质，异构体，组合物及其用途公开(公告)号：US09512073B2
公开(公告)日：2016-12-06
申请号：US13662002
申请日：2012-10-26
发明人： Yizhou Dong , Kevin Thomas Love , Robert S. Langer , Daniel Griffith Anderson , Delai Chen , Yi Chen , Arturo Jose Vegas , Akinleye C. Alabi , Yunlong Zhang
IPC分类号： A61K31/535 , C07C229/00 , C07C323/58 , C07D233/64 , C07D403/06 , C07D241/08 , C07C229/12 , C07C229/22 , C07C229/26 , C07D487/06 , C07D207/16 , C07D209/20 , C12N15/87 , C07C229/24 , C07C279/14 , C07D209/24 , C07D265/32 , C07D413/06 , C07D487/04 , C12Q1/02 , G01N33/15 , C07C271/22 , C07C229/36 , C07C237/08 , C07C237/12 , C12N15/88
CPC分类号： A61K31/7105 , A61K31/711 , A61K47/22 , A61K2121/00 , C07C229/12 , C07C229/22 , C07C229/24 , C07C229/26 , C07C229/36 , C07C237/08 , C07C237/12 , C07C271/22 , C07C279/14 , C07C323/58 , C07D207/16 , C07D209/20 , C07D209/24 , C07D233/64 , C07D241/08 , C07D265/32 , C07D403/06 , C07D413/06 , C07D487/04 , C07D487/06 , C12N15/87 , C12N15/88 , C12Q1/025 , G01N33/15
摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
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