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    Ionizable lipidoids and their uses
    1.
    发明授权
    Ionizable lipidoids and their uses 有权

    公开(公告)号：US12145912B2

    公开(公告)日：2024-11-19

    申请号：US17875982

    申请日：2022-07-28

    Applicant: Massachusetts Institute of Technology

    Inventor： Lei Miao ,  Linxian Li ,  Daniel Griffith Anderson ,  Yuxuan Huang

    IPC: C07D233/40 ,  A61K39/39 ,  C07C237/06 ,  C07C251/08 ,  C07D403/06 ,  A61K39/00

    Abstract: Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a cell.

    IONIZABLE LIPIDOIDS AND THEIR USES
    3.
    发明公开
    IONIZABLE LIPIDOIDS AND THEIR USES 审中-公开

    公开(公告)号：US20230257353A1

    公开(公告)日：2023-08-17

    申请号：US17875982

    申请日：2022-07-28

    Applicant: Massachusetts Institute of Technology

    Inventor： Lei Miao ,  Linxian Li ,  Daniel Griffith Anderson ,  Yuxuan Huang

    IPC: C07D233/40 ,  A61K39/39 ,  C07C237/06 ,  C07C251/08 ,  C07D403/06

    CPC classification number: C07D233/40 ,  A61K39/39 ,  C07C237/06 ,  C07C251/08 ,  C07D403/06 ,  A61K2039/53

    Abstract: Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a cell.

    Novel Polymers Which Resist Bacterial Attachment
    10.
    发明申请
    Novel Polymers Which Resist Bacterial Attachment 审中-公开

    公开(公告)号：US20180296733A1

    公开(公告)日：2018-10-18

    申请号：US15988753

    申请日：2018-05-24

    Applicant: The University of Nottingham ,  Massachusetts Institute of Technology

    Inventor： Paul Williams ,  Morgan Russell Alexander ,  Martyn Christopher Davies ,  Robert Langer ,  Daniel Griffith Anderson

    IPC: A61L29/16

    Abstract: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(=0)-0-]n, R (I) [H2C═CR′—C(=0)-NH—]n R (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.

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