In an example embodiment, a two-wire communication protocol engine manages control and data transmissions in a bi-directional, multi-node bus system where each node is connected over a twisted wire pair bus to another node. Some embodiments include a state machine that allows for synchronized updates of configuration data across the system, a distributed interrupt system, a synchronization pattern based on data coding used in the system, and data scrambling applied to a portion of the data transmitted over the twisted wire pair bus. The multi-node bus system comprises a master node and a plurality of slave nodes. The slave nodes can be powered over the twisted wire pair bus.