Charge to voltage conversion integrator circuitry for data acquisition front-end and other applications to provide a single-ended up a voltage using an input bias capacitance and a switching circuit to selectively place an input transistor in a negative feedback configuration in a first mode to charge the input bias capacitance to a calibration voltage for compensating integrator amplifier bias circuitry, with the switching circuit connecting an input node and the input bias capacitance in a second mode to integrate the input current signal across a feedback capacitance to provide a single-ended output voltage with the input bias capacitance maintaining a zero voltage at the input node.