Invention Grant
- Patent Title: Methods of increasing efficiency of vector penetration of target tissue
- Patent Title (中): 提高靶组织载体渗透效率的方法
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Application No.: US13636596Application Date: 2011-03-22
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Publication No.: US09546112B2Publication Date: 2017-01-17
- Inventor: Thomas Voit , Luis Garcia , Jérôme Denard , Fedor Svinartchouk
- Applicant: Thomas Voit , Luis Garcia , Jérôme Denard , Fedor Svinartchouk
- Applicant Address: FR FR FR FR FR
- Assignee: ASSOCIATION INSTITUT DE MYOLOGIE,GÉNÉTHON,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6),INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
- Current Assignee: ASSOCIATION INSTITUT DE MYOLOGIE,GÉNÉTHON,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6),INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
- Current Assignee Address: FR FR FR FR FR
- Agency: Leason Ellis LLP
- International Application: PCT/EP2011/054378 WO 20110322
- International Announcement: WO2011/117258 WO 20110929
- Main IPC: C12N15/00
- IPC: C12N15/00 ; A61K35/12 ; A61N1/30 ; C04B35/10 ; A61K38/17 ; A61K38/21 ; A61K45/06 ; C07K16/08 ; C07K16/18 ; C12N15/86 ; A61K31/522 ; A61K38/00 ; A61K48/00 ; C04B35/14 ; C04B35/565 ; C04B35/622 ; C07K14/005 ; C12N7/00
Abstract:
Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.
Public/Granted literature
- US20130189225A1 METHODS OF INCREASING EFFICIENCY OF VECTOR PENETRATION OF TARGET TISSUE Public/Granted day:2013-07-25
Information query
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