Invention Grant
- Patent Title: Triazole agonists of the APJ receptor
- Patent Title (中): APJ受体的三唑激动剂
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Application No.: US15158174Application Date: 2016-05-18
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Publication No.: US09573936B2Publication Date: 2017-02-21
- Inventor: Ning Chen , Xiaoqi Chen , Yinhong Chen , Alan C. Cheng , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , Julie Anne Heath , Daniel B. Horne , Jonathan Houze , Matthew R. Kaller , Aarif Yusuf Khakoo , David John Kopecky , Su-Jen Lai , Zhihua Ma , Lawrence R. McGee , Julio C. Medina , Jeffrey T. Mihalic , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Gayathri Swaminath , Xiaodong Wang , Kevin Yang , Wen-Chen Yeh , Mikkel V. Debenedetto , Robert P. Farrell , Simon J. Hedley , Ted C. Judd , Frank Kayser
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Bernard P. Friedrichsen
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K45/06 ; C07D213/82 ; C07D241/24 ; C07D239/30 ; C07D239/26 ; C07D401/04 ; A61K31/4439 ; A61K31/506 ; C07D413/14 ; C07B59/00 ; A61K31/497 ; A61K31/513 ; C07D471/04 ; A61K31/444 ; C07D417/14 ; C07B57/00 ; C07D405/14 ; A61K31/501 ; C07D249/08 ; C07D241/12 ; C07D213/71 ; C07D211/54
Abstract:
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
Public/Granted literature
- US20160340336A1 TRIAZOLE AGONISTS OF THE APJ RECEPTOR Public/Granted day:2016-11-24
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