发明授权
US09585865B2 Small molecule modulators of the cold and menthol receptor TRPM8
有权
冷和薄荷脑受体TRPM8的小分子调节剂
- 专利标题： Small molecule modulators of the cold and menthol receptor TRPM8
- 专利标题（中）： 冷和薄荷脑受体TRPM8的小分子调节剂
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申请号： US14563793申请日： 2014-12-08
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公开(公告)号： US09585865B2公开(公告)日： 2017-03-07
- 发明人: Michael Krohn , Holger Zinke
- 申请人： B.R.A.I.N. Biotechnology Research and Information Network AG
- 申请人地址： DE Zwingenberg
- 专利权人： B.R.A.I.N. Biotechnology Research and Information Network AG
- 当前专利权人： B.R.A.I.N. Biotechnology Research and Information Network AG
- 当前专利权人地址： DE Zwingenberg
- 代理机构： Morrison & Foerster LLP
- 优先权： EP11157329 20110308
- 主分类号： A61K31/35
- IPC分类号： A61K31/35 ; A61K31/352 ; A61K8/41 ; A61K8/49 ; A61K31/00 ; A61K31/136 ; A61K31/137 ; A61K31/351 ; A61K31/4439 ; A61K31/496 ; A61K31/513 ; A61Q5/00 ; A61Q11/00 ; A61Q17/02 ; A61Q19/00 ; A61K31/353 ; C07D311/36
摘要：
The present invention relates to the use of compounds which are capable of producing a cooling sensation when they are brought into contact with the human body. In particular, the present invention relates to the use of compounds modulating TRPM8, and optionally to the use of compounds selectively exhibiting agonist activity at the TRPM8 channel. Such compounds have applications in many fields, particularly in oral and personal hygiene products and foodstuffs, but also in pharmaceutical composition products, cosmetics, textile products and packaging products. The present invention further relates to products containing such compounds and to the medical use of such compounds.
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