- 专利标题： 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
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申请号： US11577191申请日： 2005-10-13
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公开(公告)号： US09611230B2公开(公告)日： 2017-04-04
- 发明人: Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
- 申请人： Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
- 申请人地址： US NJ South Plainfield
- 专利权人： PTC Therapeutics, Inc.
- 当前专利权人： PTC Therapeutics, Inc.
- 当前专利权人地址： US NJ South Plainfield
- 代理机构： Hoffmann & Baron, LLP
- 国际申请： PCT/US2005/036673 WO 20051013
- 国际公布： WO2006/044456 WO 20060427
- 主分类号： C07D271/10
- IPC分类号： C07D271/10 ; C07D271/107 ; C07D251/24 ; C07D231/12 ; C07D233/64 ; C07D249/08 ; C07D261/08 ; C07D263/32 ; C07D271/06 ; C07D277/30 ; C07D285/12 ; C07D307/68 ; C07D333/24 ; C07D413/12 ; C07F9/653 ; C07D401/04 ; C07D403/04 ; C07D405/04 ; C07D409/04 ; C07D413/04
摘要：
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
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