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公开(公告)号：US07781478B2
公开(公告)日：2010-08-24
申请号：US11653450
申请日：2007-01-16
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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2.发明申请Compounds for Nonsense Suppression, Use of These Compounds for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases 审中-公开无意义抑制的化合物，这些化合物用于制造用于治疗体细胞突变相关疾病的药物的用途公开(公告)号：US20080269191A1
公开(公告)日：2008-10-30
申请号：US11577176
申请日：2005-10-13
申请人： Richard Wilde , Ellen Welch , Gary M. Karp
发明人： Richard Wilde , Ellen Welch , Gary M. Karp
IPC分类号： A61K31/4439 , C07D413/04 , A61K31/423 , C07D263/57 , C07D413/14 , A61P35/00 , C12N5/06
CPC分类号： C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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3.发明授权3-(3-aryloxyphenyl)-1 (substituted methyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents 失效3-（3-芳氧基苯基）-1（取代的甲基）-s-三嗪-2,4,6-氧代或噻二唑除草剂
公开(公告)号：US5604180A
公开(公告)日：1997-02-18
申请号：US458635
申请日：1995-06-02
IPC分类号： A01N43/64 , C07D251/34 , C07D401/12 , C07D251/32 , A01N43/66
CPC分类号： C07D401/12 , A01N43/64 , C07D251/34
摘要： There is provided a 3-(3-aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.
摘要翻译： 提供具有结构式I（I）的3-（3-芳氧基苯基）-1-（取代的甲基）-s-三嗪-2,4,6-氧代或硫代四氢化物。进一步提供了一种组合物和 包括用于控制不期望的植物物种的化合物的方法。
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公开(公告)号：US5182397A
公开(公告)日：1993-01-26
申请号：US738398
申请日：1991-07-31
申请人： Michael E. Condon , Gary M. Karp , Jeffrey H. Birk
发明人： Michael E. Condon , Gary M. Karp , Jeffrey H. Birk
IPC分类号： A01N43/38 , A01N43/40 , C07D209/34 , C07D209/96 , C07D401/12
CPC分类号： C07D401/12 , A01N43/38 , A01N43/40 , C07D209/34 , C07D209/96
摘要： There are provided aryloxy-1'-(substituted)-spiro[cycloalkane-1,3'-indolin]-2'-one compounds, their herbicidal use, particularly for the selective control of undesirable plant species in the presence of cereal crops such as rice and wheat, and a method for the preparation thereof.
摘要翻译： 提供了芳氧基-1' - （取代的） - 螺[环烷烃-1,3'-二氢吲哚] -2'-酮化合物，它们的除草用途，特别是在谷类作物存在下选择性地控制不期望的植物物种 作为水稻和小麦，以及其制备方法。
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5.发明申请METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH 有权从具有非扩散性突变的DNA生产功能性蛋白质的方法和与之相关的疾病的治疗方法公开(公告)号：US20110046136A1
公开(公告)日：2011-02-24
申请号：US12294952
申请日：2007-03-29
申请人： Neil G. Almstead , Guangming Chen , Hirawat Samit , Peter Seongwoo Hwang , Gary M. Karp , Langdon Miller , Young-Choon Moon , Hongyu Ren , James J. Takasugi , Ellen M. Welch , Richard G. Wilde , Paul Kennedy
发明人： Neil G. Almstead , Guangming Chen , Hirawat Samit , Peter Seongwoo Hwang , Gary M. Karp , Langdon Miller , Young-Choon Moon , Hongyu Ren , James J. Takasugi , Ellen M. Welch , Richard G. Wilde , Paul Kennedy
IPC分类号： A61K31/4245 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/4439 , A61K31/519 , A61K31/498 , A61K31/53 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/433 , A61K31/421 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/42 , A61K31/4164 , A61K31/34 , A61K31/381 , A61K31/4196 , A61P21/00 , A61P11/00 , A61P7/00 , A61P25/00 , A61P13/12 , A61P27/02
CPC分类号： A61K31/4245 , A61K31/00 , A61K31/40 , A61K31/41 , A61K31/4162 , A61K31/44 , A61K31/46
摘要： The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.
摘要翻译： 本发明涉及由包含无义突变的核酸序列编码的功能性蛋白质。 本发明还涉及用于产生由包含无义突变的核酸序列编码的功能性蛋白质的方法以及用于预防，管理和/或治疗与基因中的无义突变有关的疾病的这些蛋白质的用途。
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公开(公告)号：US20090253699A1
公开(公告)日：2009-10-08
申请号：US11577191
申请日：2005-10-13
申请人： Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
发明人： Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
IPC分类号： A61K31/5377 , A61K31/4245 , C07D271/10 , C12N5/00 , C07D413/02 , A61K31/433 , C07D285/12 , A61K31/421 , C07D263/30 , A61K31/415 , C07D231/10 , A61K31/426 , C07D277/20 , C07D307/02 , A61K31/34 , A61P37/06 , A61P7/00 , A61P25/00 , A61P9/00 , A61P29/00
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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7.发明授权Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases 有权吡唑或三唑化合物及其用于制备用于治疗体细胞突变相关疾病的药物的用途公开(公告)号：US09051342B2
公开(公告)日：2015-06-09
申请号：US11577177
申请日：2005-10-13
申请人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Jeffrey A. Campbell , Hongyu Ren , Guangming Chen
发明人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Jeffrey A. Campbell , Hongyu Ren , Guangming Chen
IPC分类号： A61K31/397 , A61K31/41 , A61K31/415 , C07F9/653 , C07D231/12 , C07D233/64 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D413/12
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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公开(公告)号：US20080119473A1
公开(公告)日：2008-05-22
申请号：US11577189
申请日：2005-10-13
申请人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Hongyu Ren
发明人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Hongyu Ren
IPC分类号： A61K31/53 , C07D239/42 , A61K31/435
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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9.发明授权1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents 失效1-（3-杂环基苯基）-s-三嗪-2,4,6-氧代或噻二唑除草剂
公开(公告)号：US5610120A
公开(公告)日：1997-03-11
申请号：US458639
申请日：1995-06-02
申请人： Alvin D. Crews, Jr. , Philip M. Harrington , Gary M. Karp , Mark C. Manfredi , Michael A. Guaciaro
发明人： Alvin D. Crews, Jr. , Philip M. Harrington , Gary M. Karp , Mark C. Manfredi , Michael A. Guaciaro
IPC分类号： A01N43/64 , A01N43/90 , A01N47/38 , A01N47/40 , C07D209/48 , C07D251/30 , C07D403/10 , C07D403/12 , C07D513/04 , A01N43/82 , A01N43/66 , A01N43/707
CPC分类号： C07D209/48 , A01N43/64 , A01N43/90 , A01N47/38 , A01N47/40 , C07D251/30 , C07D403/10 , C07D403/12 , C07D513/04
摘要： There is provided a 1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.
摘要翻译： 提供具有结构式I（I）的1-（3-杂环基苯基）-s-三嗪-2,4,6-氧代或噻二唑化合物。还提供了一种组合物和方法，其包含用于 控制不良植物物种。
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10.发明授权3-(3-aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents 失效3-（3-芳氧基苯基）-1-（取代的甲基）-s-三嗪-2,4,6-氧代或噻二唑除草剂
公开(公告)号：US5519133A
公开(公告)日：1996-05-21
申请号：US458336
申请日：1995-06-02
IPC分类号： A01N43/64 , C07D251/34 , C07D401/12 , C07D251/36
CPC分类号： C07D401/12 , A01N43/64 , C07D251/34
摘要： There is provided a 3-(3-aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.
摘要翻译： 提供具有结构式I（I）的3-（3-芳氧基苯基）-1-（取代的甲基）-s-三嗪-2,4,6-氧代或硫代四氢化物。进一步提供了一种组合物和 包括用于控制不期望的植物物种的化合物的方法。
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