Invention Grant
- Patent Title: Triazole agonists of the APJ receptor
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Application No.: US15297940Application Date: 2016-10-19
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Publication No.: US09656997B2Publication Date: 2017-05-23
- Inventor: Ning Chen , Xiaoqi Chen , Alan C. Cheng , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , Julie Anne Heath , Daniel B. Horne , Jonathan Houze , Matthew R. Kaller , David John Kopecky , Su-Jen Lai , Zhihua Ma , Lawrence R. McGee , Julio C. Medina , Jeffrey T. Mihalic , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Gayathri Swaminath , Xiaodong Wang , Kevin Yang , Mikkel V. Debenedetto , Robert P. Farrell , Simon J. Hedley , Ted C. Judd , Frank Kayser
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Bernard P. Friedrichsen
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; A61K31/695 ; A61K31/501 ; A61K31/497 ; A61K31/444 ; A61K45/06 ; A61K31/506 ; C07D401/14 ; C07D401/04 ; C07D413/04 ; A61K31/513 ; C07B57/00 ; C07B59/00 ; C07D211/54 ; C07D213/71 ; C07D213/82 ; C07D239/26 ; C07D239/30 ; C07D241/12 ; C07D241/24 ; C07D249/08 ; C07D405/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; C07D401/12 ; C07F7/08 ; A61K31/437 ; C07C311/13 ; C07D213/61 ; C07D239/34 ; C07D241/18 ; C07D295/16
Abstract:
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
Public/Granted literature
- US20170042872A1 TRIAZOLE AGONISTS OF THE APJ RECEPTOR Public/Granted day:2017-02-16
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