- Patent Title: Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto
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Application No.: US13975678Application Date: 2013-08-26
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Publication No.: US09657316B2Publication Date: 2017-05-23
- Inventor: Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
- Applicant: Genomatica, Inc.
- Applicant Address: US CA San Diego
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- Main IPC: C12P7/24
- IPC: C12P7/24 ; C12P7/28 ; C12P7/18 ; C12N1/20 ; C12N1/00 ; C07H21/04 ; C08G18/00 ; C08G63/00 ; C08G63/02 ; C12N9/04 ; C12N9/06 ; C12N9/10 ; C07D207/12 ; C08G18/32 ; C08G63/06 ; C08G63/12 ; C08G63/66 ; C08G69/26 ; C12N9/88 ; C12P19/02
Abstract:
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
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