- 专利标题： Compositions and methods of targeting mutant K-Ras
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申请号： US13601227申请日： 2012-08-31
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公开(公告)号： US09687491B1公开(公告)日： 2017-06-27
- 发明人: Shahrooz Rabizadeh , Kayvan Niazi , Oleksandr Buzko , Justin Golovato , Patrick Soon-Shiong
- 申请人： Shahrooz Rabizadeh , Kayvan Niazi , Oleksandr Buzko , Justin Golovato , Patrick Soon-Shiong
- 申请人地址： US CA Culver City
- 专利权人： NantBioscience, Inc.
- 当前专利权人： NantBioscience, Inc.
- 当前专利权人地址： US CA Culver City
- 代理机构： Fish & Tsang, LLP
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K31/535 ; A01N43/40 ; A61K31/445 ; A61K31/497 ; A01N43/42 ; A61K31/47 ; A61K31/44 ; A01N43/82 ; A61K31/41 ; A01N43/90 ; A61K31/519 ; A01N43/78 ; A61K31/425 ; C12N9/96 ; A61K31/5377 ; A61K31/4245 ; A61K31/428 ; A61K31/435 ; A61K31/454 ; A61K31/4709 ; A61K31/496 ; A61K31/506 ; A61K31/517 ; A61K45/06
摘要：
The invention relates to a method of modeling K-Ras proteins with one or more mutations that result in constitutive activity, and identifying compounds that inhibit interactions among activated K-Ras proteins and their upstream and downstream effectors.