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公开(公告)号：US10766879B2
公开(公告)日：2020-09-08
申请号：US15553890
申请日：2015-02-27
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Qinwei Wang , Laxman Nallan , David Ho , Tulay Polat , Forrest Arp , Paul Weingarten
IPC分类号： C07D403/12 , A61K31/506 , A61P37/00 , C07D401/14 , C07D403/14 , C07D417/14 , C07D487/04 , A61P29/00 , A61P35/00 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
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2.发明授权公开(公告)号：US09409903B2
公开(公告)日：2016-08-09
申请号：US14531585
申请日：2014-11-03
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Qinwei Wang , David Ho , Laxman Nallan , Tulay Polat , Xiaowen Sun , Neil Desai
IPC分类号： C07D417/14 , C07D417/12 , C07D405/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14
CPC分类号： C07D417/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12
摘要： The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
摘要翻译： 本发明提供了三嗪化合物及其用于调节蛋白激酶和治疗由所述蛋白激酶介导的疾病的方法。
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公开(公告)号：US09687491B1
公开(公告)日：2017-06-27
申请号：US13601227
申请日：2012-08-31
IPC分类号： A61K38/00 , A61K31/535 , A01N43/40 , A61K31/445 , A61K31/497 , A01N43/42 , A61K31/47 , A61K31/44 , A01N43/82 , A61K31/41 , A01N43/90 , A61K31/519 , A01N43/78 , A61K31/425 , C12N9/96 , A61K31/5377 , A61K31/4245 , A61K31/428 , A61K31/435 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K45/06
CPC分类号： A61K31/5377 , A61K31/4245 , A61K31/428 , A61K31/435 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/519 , A61K38/00 , A61K45/06
摘要： The invention relates to a method of modeling K-Ras proteins with one or more mutations that result in constitutive activity, and identifying compounds that inhibit interactions among activated K-Ras proteins and their upstream and downstream effectors.
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4.发明授权公开(公告)号：US09458137B2
公开(公告)日：2016-10-04
申请号：US14440817
申请日：2013-11-05
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Qinwei Wang , David Ho , Tulay Polat , Laxman Nallan , Patrick Soon-Shiong
IPC分类号： A61K31/506 , C07D403/14 , A61K45/06 , C07D403/12 , C07D401/14 , A61K31/5377 , A61K31/541
CPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
摘要翻译： 本发明一般涉及化合物用于治疗各种疾病，疾病和病理状况，更具体地涉及使用取代的吲哚-5-醇衍生物调节蛋白激酶和治疗蛋白激酶介导的疾病。
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5.发明授权Cyclic sulfonamide containing derivatives as inhibitors of hedgehog signaling pathway 有权含有磺酰胺的环状磺酰胺作为刺猬蛋白信号通路抑制剂的衍生物公开(公告)号：US09499539B2
公开(公告)日：2016-11-22
申请号：US14440796
申请日：2013-11-04
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Chengzhi Yu , Forrest Arp , Paul Weingarten , Patrick Soon-Shiong
IPC分类号： C07D275/00 , C07D471/04 , C07D417/12 , C07D419/12 , C07D275/02 , C07D279/02 , C07D291/06
CPC分类号： A61K31/425 , C07D275/02 , C07D279/02 , C07D291/06 , C07D417/12 , C07D419/12 , C07D471/04
摘要： The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angiogenesis mediated diseases.
摘要翻译： 本发明一般涉及产生和使用含环状磺酰胺的衍生物以抑制刺猬蛋白信号通路，以及这些化合物用于治疗过度增殖性疾病和血管生成介导的疾病的用途。
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公开(公告)号：US08946169B2
公开(公告)日：2015-02-03
申请号：US13791009
申请日：2013-03-08
发明人： Vuong Trieu , Neil P. Desai , Patrick Soon-Shiong
IPC分类号： A01N61/00 , A61K31/00 , A61K38/00 , A61K49/00 , G01N1/00 , G01N33/48 , G01N33/53 , G01N33/567 , G01N33/574 , C12Q1/00 , A61K47/48
CPC分类号： G01N33/57488 , A61K31/337 , G01N33/574 , G01N33/57407 , G01N33/57484 , G01N33/57492 , G01N2333/4727 , G01N2333/71 , G01N2333/91205 , G01N2800/52 , Y10T436/25
摘要： The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.
摘要翻译： 本发明提供用于预测或确定哺乳动物肿瘤对化学治疗剂的反应和用于治疗哺乳动物肿瘤的方法，包括检测和定量分离自哺乳动物的样品中的SPARC蛋白或RNA。 本发明还提供了用于预测哺乳动物肿瘤对化学治疗剂的反应的试剂盒，其包括用于从肿瘤分离蛋白质或RNA的手段，SPARC蛋白或RNA检测和定量方法，控制RNA和用于预测 基于肿瘤中SPARC蛋白或RNA水平的肿瘤反应。
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公开(公告)号：US09550760B2
公开(公告)日：2017-01-24
申请号：US14775434
申请日：2014-03-17
申请人： NantBioScience, Inc.
发明人： Chunlin Tao
IPC分类号： C07D403/14 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/541 , C07D401/14
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/541 , C07D401/14 , C07D403/14 , C07D413/14
摘要： The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
摘要翻译： 本发明一般涉及化合物用于治疗各种疾病，疾病和病理状况，更具体地涉及使用取代的吲哚-5-醇衍生物调节蛋白激酶和治疗蛋白激酶介导的疾病。
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8.发明授权Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling 有权异喹啉，喹啉和喹唑啉衍生物作为刺猬蛋白信号传导的抑制剂公开(公告)号：US09345699B2
公开(公告)日：2016-05-24
申请号：US13376813
申请日：2010-06-09
申请人： Chunlin Tao , Xiaowen Sun , Hongna Han , Lukasz Koroniak , Neil Desai
发明人： Chunlin Tao , Xiaowen Sun , Hongna Han , Lukasz Koroniak , Neil Desai
IPC分类号： C07D217/16 , A61K31/472 , A61K31/47 , A61K31/517 , C07D239/74 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
CPC分类号： A61K31/47 , A61K31/517 , C07D217/16 , C07D239/74 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The invention provides isoquinoline, quinoline, and quinazoline derivatives to treat a variety of disorders, diseases and pathologic conditions, and more specifically to the use of isoquinoline, quinoline, and quinazoline derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds to the treatment of hyperproliferative diseases and pathologic angiogenesis.
摘要翻译： 本发明提供异喹啉，喹啉和喹唑啉衍生物，用于治疗各种疾病，疾病和病理状况，更具体地涉及使用异喹啉，喹啉和喹唑啉衍生物抑制刺猬蛋白信号通路以及使用这些化合物 治疗过度增殖性疾病和病理性血管生成。
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9.发明申请公开(公告)号：US20150291564A1
公开(公告)日：2015-10-15
申请号：US14440817
申请日：2013-11-05
发明人： Chunlin Tao , Qinwei Wang , David Ho , Tulay Polat , Laxman Nallan , Patrick Soon-Shiong
IPC分类号： C07D403/14 , A61K31/5377 , A61K31/541 , A61K31/506
CPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
摘要翻译： 本发明一般涉及化合物用于治疗各种疾病，疾病和病理状况，更具体地涉及使用取代的吲哚-5-醇衍生物调节蛋白激酶和治疗蛋白激酶介导的疾病。
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公开(公告)号：US09078902B2
公开(公告)日：2015-07-14
申请号：US13376814
申请日：2010-06-09
申请人： Chunlin Tao , Qinwei Wang , Laxman Nallan , Tulay Polat , David Ho , Neil Desai
发明人： Chunlin Tao , Qinwei Wang , Laxman Nallan , Tulay Polat , David Ho , Neil Desai
IPC分类号： C07D403/14 , C07D405/14 , C07D409/14 , A61K31/496 , A61K31/53 , C07D403/12 , C07D417/12 , C07D417/14 , A61P35/00 , C07D401/14
CPC分类号： A61K31/53 , A61K31/496 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.
摘要翻译： 本发明提供三嗪衍生物，并进一步提供使用这些化合物调节蛋白激酶和治疗由蛋白激酶介导的疾病和病症的方法。
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