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公开(公告)号：US09789121B2
公开(公告)日：2017-10-17
申请号：US13168880
申请日：2011-06-24
IPC分类号： C12N15/63 , A61K31/555 , A61K31/505 , G01N33/50
CPC分类号： A61K31/555 , A61K31/505 , C12N2503/02 , C12N2510/00 , G01N33/5011
摘要： This invention provides a novel screening system for identifying p53 mimetics/agonists. Also provided are small organic molecules that act as effective p53 mimetics/agonists.
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公开(公告)号：US20120040457A1
公开(公告)日：2012-02-16
申请号：US13168880
申请日：2011-06-24
CPC分类号： A61K31/555 , A61K31/505 , C12N2503/02 , C12N2510/00 , G01N33/5011
摘要： This invention provides a novel screening system for identifying p53 mimetics/agonists. Also provided are small organic molecules that act as effective p53 mimetics/agonists.
摘要翻译： 本发明提供了用于鉴定p53模拟物/激动剂的新型筛选系统。 还提供了作为有效p53模拟物/激动剂的小有机分子。
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公开(公告)号：US09777297B2
公开(公告)日：2017-10-03
申请号：US14356386
申请日：2012-11-02
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N15/52 , C12P7/24 , C12Y101/01157 , C12Y102/01057 , C12Y103/01086 , C12Y203/01009
摘要： Microorganisms and methods of producing n-butyraldehyde with enhanced yields are presented in which a microorganism is engineered to enhance the conversion of a carbon source into n-butyraldehyde. The n-butyraldehyde is recovered by way of a gas stripping process that occurs during the conversion process, providing significantly greater product yield than post-fermentation recovery of n-butyraldehyde alone.
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公开(公告)号：US09107863B2
公开(公告)日：2015-08-18
申请号：US11389695
申请日：2006-03-27
IPC分类号： A61K39/00 , A61K31/365
CPC分类号： G01N33/5023 , A61K31/365 , A61K39/0011 , A61K2039/5154 , G01N2333/90241 , G01N2500/10
摘要： The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or standard chemotherapeutic agents. In one embodiment, the invention involves a method comprising: a) providing a subject with tumor cells, b) removing at least a portion of said tumor cells from said subject to create removed cells, c) treating at least a portion of said removed cells ex vivo, using stimulating agents, including thapsigargin and/or thapsigargin-related compounds, so as to create treated tumor cells; and d) introducing said treated tumor cells (or fragments thereof) in vivo into the same subject to generate anticancer therapeutic effects.
摘要翻译： 本发明一般涉及癌症的预防和/或治疗，更具体地涉及治疗包括实体瘤及其转移瘤在内的肿瘤，无辐射或标准化学治疗剂。 在一个实施方案中，本发明涉及一种方法，其包括：a）向受试者提供肿瘤细胞，b）从所述受试者中移除所述肿瘤细胞的至少一部分以产生去除的细胞，c）将至少一部分所述去除的细胞 离体使用刺激剂，包括毒胡萝卜素和/或毒胡萝卜素相关化合物，以产生经治疗的肿瘤细胞; 和d）将所述经处理的肿瘤细胞（或其片段）体内引入相同受试者以产生抗癌治疗效果。
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公开(公告)号：US09206443B2
公开(公告)日：2015-12-08
申请号：US14004135
申请日：2012-03-14
IPC分类号： C12P7/02 , C12N9/88 , C12N15/63 , C12N15/67 , C12P7/24 , C12N9/04 , C12N9/10 , C12N15/52 , C07C29/141
CPC分类号： C12P7/16 , C07C29/141 , C07C31/125 , C12N1/16 , C12N1/20 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12N15/52 , C12N15/63 , C12N15/67 , C12N15/70 , C12N15/74 , C12P7/02 , C12P7/24 , Y02E50/17 , C07C31/08 , C07C31/10 , C07C31/12
摘要： An improved process for alcohol production includes microbial fermentation using a genetically modified microorganism to produce substantial quantities of aldehydes that are stripped from the fermentation medium and condensed. So produced aldehydes are converted in an ex vivo process to corresponding alcohols.
摘要翻译： 用于醇生产的改进方法包括使用经遗传修饰的微生物的微生物发酵产生大量的从发酵培养基中汽提并冷凝的醛。 所以生产的醛在离体过程中被转化为相应的醇。
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公开(公告)号：US20150006445A1
公开(公告)日：2015-01-01
申请号：US14320214
申请日：2014-06-30
CPC分类号： G16H50/20
摘要： The present inventive subject matter provides apparatus, systems, and methods in which a diagnostic test is identified, where the diagnostic test is for determining whether a particular treatment is effective for a particular patient based on one or more characteristics of a patient's cells. When a treatment is developed with the potential to treat one or more diseases, the drug can have different effects on different cell lines related to the diseases. A machine learning system is programmed to infer a measurable cell characteristic, out of many different measurable cell characteristics, that has a desirable correlation with the sensitivity data of different cell lines to a treatment. The machine learning system is programmed to then determine, based on the correlation, a threshold level of the cell characteristic the patient should exhibit in order to recommend administering the treatment.
摘要翻译： 本发明的主题提供了其中识别诊断测试的装置，系统和方法，其中诊断测试用于基于患者细胞的一个或多个特征来确定特定治疗是否对特定患者有效。 当开发具有治疗一种或多种疾病潜力的治疗时，该药物可以对与疾病相关的不同细胞系具有不同的作用。 机器学习系统被编程为推断出许多不同可测量的细胞特征中的可测量细胞特征，其与不同细胞系对治疗的敏感性数据具有期望的相关性。 机器学习系统被编程为然后基于相关性来确定患者应该展示的细胞特征的阈值水平以推荐施用治疗。
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公开(公告)号：US20100278874A1
公开(公告)日：2010-11-04
申请号：US12770638
申请日：2010-04-29
IPC分类号： A61K39/00 , A61K31/343 , A61P35/00
CPC分类号： G01N33/5023 , A61K31/365 , A61K39/0011 , A61K2039/5154 , G01N2333/90241 , G01N2500/10
摘要： The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or standard chemotherapeutic agents. In one embodiment, the invention involves a method comprising: a) providing a subject with tumor cells, b) removing at least a portion of said tumor cells from said subject to create removed cells, c) treating at least a portion of said removed cells ex vivo, using stimulating agents, including thapsigargin and/or thapsigargin-related compounds, so as to create treated tumor cells; and d) introducing said treated tumor cells (or fragments thereof) in vivo into the same subject to generate anticancer therapeutic effects.
摘要翻译： 本发明一般涉及癌症的预防和/或治疗，更具体地涉及治疗包括实体瘤及其转移瘤在内的肿瘤，无辐射或标准化学治疗剂。 在一个实施方案中，本发明涉及一种方法，其包括：a）向受试者提供肿瘤细胞，b）从所述受试者中除去至少一部分所述肿瘤细胞以产生去除的细胞，c）将至少一部分所述去除的细胞 离体使用刺激剂，包括毒胡萝卜素和/或毒胡萝卜素相关化合物，以产生经治疗的肿瘤细胞; 和d）将所述经处理的肿瘤细胞（或其片段）体内引入相同受试者以产生抗癌治疗效果。
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公开(公告)号：US09687491B1
公开(公告)日：2017-06-27
申请号：US13601227
申请日：2012-08-31
IPC分类号： A61K38/00 , A61K31/535 , A01N43/40 , A61K31/445 , A61K31/497 , A01N43/42 , A61K31/47 , A61K31/44 , A01N43/82 , A61K31/41 , A01N43/90 , A61K31/519 , A01N43/78 , A61K31/425 , C12N9/96 , A61K31/5377 , A61K31/4245 , A61K31/428 , A61K31/435 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K45/06
CPC分类号： A61K31/5377 , A61K31/4245 , A61K31/428 , A61K31/435 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/519 , A61K38/00 , A61K45/06
摘要： The invention relates to a method of modeling K-Ras proteins with one or more mutations that result in constitutive activity, and identifying compounds that inhibit interactions among activated K-Ras proteins and their upstream and downstream effectors.
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公开(公告)号：US08895031B2
公开(公告)日：2014-11-25
申请号：US12770638
申请日：2010-04-29
IPC分类号： A61K39/00 , A61K31/365
CPC分类号： G01N33/5023 , A61K31/365 , A61K39/0011 , A61K2039/5154 , G01N2333/90241 , G01N2500/10
摘要： The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or standard chemotherapeutic agents. In one embodiment, the invention involves a method comprising: a) providing a subject with tumor cells, b) removing at least a portion of said tumor cells from said subject to create removed cells, c) treating at least a portion of said removed cells ex vivo, using stimulating agents, including thapsigargin and/or thapsigargin-related compounds, so as to create treated tumor cells; and d) introducing said treated tumor cells (or fragments thereof) in vivo into the same subject to generate anticancer therapeutic effects.
摘要翻译： 本发明一般涉及癌症的预防和/或治疗，更具体地涉及治疗包括实体瘤及其转移瘤在内的肿瘤，无辐射或标准化学治疗剂。 在一个实施方案中，本发明涉及一种方法，其包括：a）向受试者提供肿瘤细胞，b）从所述受试者中除去至少一部分所述肿瘤细胞以产生去除的细胞，c）将至少一部分所述去除的细胞 离体使用刺激剂，包括毒胡萝卜素和/或毒胡萝卜素相关化合物，以产生经治疗的肿瘤细胞; 和d）将所述经处理的肿瘤细胞（或其片段）体内引入相同受试者以产生抗癌治疗效果。
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公开(公告)号：US20140011231A1
公开(公告)日：2014-01-09
申请号：US14004135
申请日：2012-03-14
CPC分类号： C12P7/16 , C07C29/141 , C07C31/125 , C12N1/16 , C12N1/20 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12N15/52 , C12N15/63 , C12N15/67 , C12N15/70 , C12N15/74 , C12P7/02 , C12P7/24 , Y02E50/17 , C07C31/08 , C07C31/10 , C07C31/12
摘要： An improved process for alcohol production includes microbial fermentation using a genetically modified microorganism to produce substantial quantities of aldehydes that are stripped from the fermentation medium and condensed. So produced aldehydes are converted in an ex vivo process to corresponding alcohols.
摘要翻译： 用于醇生产的改进方法包括使用经遗传修饰的微生物的微生物发酵产生大量的从发酵培养基中汽提并冷凝的醛。 所以生产的醛在离体过程中被转化为相应的醇。
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