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1.发明授权公开(公告)号：US08633198B1
公开(公告)日：2014-01-21
申请号：US13622807
申请日：2012-09-19
申请人： Kayvan Niazi , Shahrooz Rabizadeh , Anne-Laure Le Ny , Oleksandr Buzko , Justin Golovato , Patrick Soon-Shiong
发明人： Kayvan Niazi , Shahrooz Rabizadeh , Anne-Laure Le Ny , Oleksandr Buzko , Justin Golovato , Patrick Soon-Shiong
IPC分类号： A01N43/90 , A61K31/519 , A01N37/18 , A61K38/00 , A61P31/12
CPC分类号： A61K31/519 , C07D487/04
摘要： Antiviral compositions and methods are contemplated that are especially effective in the treatment and prevention of influenza A viruses. Also presented are cellular assays to identify small molecule compounds having antiviral properties, particularly as it relates to detection of influenza A RNA-dependent RNA polymerase activity in a mammalian cell independent of other influenza A components. Preferred assays allow for identification of viral replication inhibitors that do not disrupt normal cellular activity.
摘要翻译： 预期抗病毒组合物和方法在治疗和预防甲型流感病毒方面特别有效。 还提供了用于鉴定具有抗病毒性质的小分子化合物的细胞测定法，特别是涉及在独立于其它甲型流感病毒组分的哺乳动物细胞中检测甲型流感病毒RNA依赖性RNA聚合酶活性。 优选的测定允许鉴定不破坏正常细胞活性的病毒复制抑制剂。
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公开(公告)号：US09687491B1
公开(公告)日：2017-06-27
申请号：US13601227
申请日：2012-08-31
IPC分类号： A61K38/00 , A61K31/535 , A01N43/40 , A61K31/445 , A61K31/497 , A01N43/42 , A61K31/47 , A61K31/44 , A01N43/82 , A61K31/41 , A01N43/90 , A61K31/519 , A01N43/78 , A61K31/425 , C12N9/96 , A61K31/5377 , A61K31/4245 , A61K31/428 , A61K31/435 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K45/06
CPC分类号： A61K31/5377 , A61K31/4245 , A61K31/428 , A61K31/435 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/519 , A61K38/00 , A61K45/06
摘要： The invention relates to a method of modeling K-Ras proteins with one or more mutations that result in constitutive activity, and identifying compounds that inhibit interactions among activated K-Ras proteins and their upstream and downstream effectors.
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