Invention Grant
- Patent Title: Isotopically-labeled proteome standards
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Application No.: US13951354Application Date: 2013-07-25
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Publication No.: US09733213B2Publication Date: 2017-08-15
- Inventor: John Leite , Robert Pope , Mahbod Hajivandi , Xiquan Liang
- Applicant: LIFE TECHNOLOGIES CORPORATION
- Applicant Address: US CA Carlsbad
- Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee Address: US CA Carlsbad
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G01N27/62 ; G01N33/60 ; G01N33/68

Abstract:
The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.
Public/Granted literature
- US20140065625A1 Isotopically-Labeled Proteome Standards Public/Granted day:2014-03-06
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