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公开(公告)号：US10829787B2
公开(公告)日：2020-11-10
申请号：US15294586
申请日：2016-10-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Xin Yu , Xiquan Liang , Xavier de Mollerat du Jeu , Robert Jason Potter
Abstract: Provided herein are compositions and methods useful, inter alia, for the delivery of ribonucleoprotein complexes (e.g., Cas9/guide RNA complexes) into cells. The compositions and methods provided herein are particularly useful for the delivery of ribonucleoprotein complexes into pluripotent cells and lymphatic cells.
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公开(公告)号：US09879283B2
公开(公告)日：2018-01-30
申请号：US14879872
申请日：2015-10-09
Inventor： Namritha Ravinder , Korbinian Heil , Yizhu Guo , Xiquan Liang , Robert Potter , Sanjay Kumar
CPC classification number: C12N15/907 , C12N15/102 , C12N15/11 , C12N2310/3519 , C12P19/34 , C12Q1/686 , C12Q2525/143
Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.
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公开(公告)号：US20160186166A1
公开(公告)日：2016-06-30
申请号：US14964060
申请日：2015-12-09
Applicant: Life Technologies Corporation , Thermo Fisher Scientific Geneart Gmbh , Life Technologies As
Inventor： Thomas POEHMERER , Phillip Kuhn , Frank Notka , Andreas Zeidler , Korbinian Heil , Axel Trefzer , Geir Fonnum , Federico Katzen , Kristian Andersson , Xiquan Liang
CPC classification number: C12N15/101 , B01J2219/00468 , B01J2219/005 , B01J2219/00653 , B01J2219/00695 , B01J2219/00722 , B01L3/502715 , B01L3/502761 , B01L2200/0642 , B01L2200/0647 , B01L2300/0819 , B01L2300/0893 , B01L2400/046 , B01L2400/0487 , B03C5/026 , B03C2201/26 , C25B3/10 , C25B9/18 , C25B11/04 , C25B15/02
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US20200010827A1
公开(公告)日：2020-01-09
申请号：US16518099
申请日：2019-07-22
Applicant: THERMO FISHER SCIENTIFIC GENEART GMBH , LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas Poehmerer , Phillip Kuhn , Frank Notka , Andreas Zeidler , Korbinian Heil , Axel Trefzer , Geir Fonnum , Federico Katzen , Kristian Andersson , Xiquan Liang
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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Patent Agency Ranking
公开(公告)号：US10428327B2
公开(公告)日：2019-10-01
申请号：US15605586
申请日：2017-05-25
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Xiquan Liang , Robert Potter , Namritha Ravinder
IPC: C12N15/10 , C12N15/113 , C12N15/90
Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.
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公开(公告)号：US09733213B2
公开(公告)日：2017-08-15
申请号：US13951354
申请日：2013-07-25
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： John Leite , Robert Pope , Mahbod Hajivandi , Xiquan Liang
CPC classification number: G01N27/62 , G01N33/60 , G01N33/6848 , G01N33/6851 , G01N2458/15 , Y10T436/24
Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.
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公开(公告)号：US10563240B2
公开(公告)日：2020-02-18
申请号：US14775648
申请日：2014-03-14
Inventor： Todd Peterson , Axel Trefzer , Thomas Poehmerer , Federico Katzen , Xiquan Liang
IPC: C12P19/34
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US20160102322A1
公开(公告)日：2016-04-14
申请号：US14879872
申请日：2015-10-09
Inventor： Namritha Ravinder , Korbinian Heil , Yizhu Guo , Xiquan Liang , Robert Potter
CPC classification number: C12N15/907 , C12N15/102 , C12N15/11 , C12N2310/3519 , C12P19/34 , C12Q1/686 , C12Q2525/143
Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.
Abstract translation: 本公开一般涉及用于细胞遗传修饰的组合物和方法。 特别地，本公开涉及CRISPR试剂和这些试剂的用途。
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公开(公告)号：US10753905B2
公开(公告)日：2020-08-25
申请号：US15597928
申请日：2017-05-17
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： John Leite , Robert Pope , Mahbod Hajivandi , Xiquan Liang
Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.
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