Invention Grant
- Patent Title: Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound
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Application No.: US15586913Application Date: 2017-05-04
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Publication No.: US09751821B1Publication Date: 2017-09-05
- Inventor: Manabu Yaosaka , Tomohisa Utsunomiya , Yuji Moriyama , Tomohiro Matsumoto , Kazutaka Matoba
- Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.
- Applicant Address: JP Tokyo
- Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.
- Current Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.
- Current Assignee Address: JP Tokyo
- Agency: Oliff PLC
- Priority: JP2007-169151 20070627; JP2007-225992 20070831; JP2007-293175 20071112
- Main IPC: C07C45/72
- IPC: C07C45/72 ; C07D413/14 ; C07C51/367 ; C07C231/12 ; C07D213/04 ; C07C67/343 ; C07D249/08 ; C07D233/60 ; C07D401/04 ; C07D413/12

Abstract:
There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.
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