- 专利标题: Integrated organ and tissue printing methods, system and apparatus
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申请号: US14476359申请日: 2014-09-03
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公开(公告)号: US09764516B2公开(公告)日: 2017-09-19
- 发明人: Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
- 申请人: Wake Forest University Health Sciences
- 申请人地址: US NC Winston-Salem
- 专利权人: Wake Forest University Health Sciences
- 当前专利权人: Wake Forest University Health Sciences
- 当前专利权人地址: US NC Winston-Salem
- 代理机构: Myers Bigel, P.A.
- 主分类号: C12N5/00
- IPC分类号: C12N5/00 ; C12N5/02 ; A61F13/00 ; B29C67/00 ; A61L27/20 ; A61L27/22 ; A61L27/38 ; A61L27/52 ; A61L27/26 ; A61K35/12 ; B33Y10/00 ; B33Y30/00 ; B33Y70/00 ; B33Y80/00 ; B29K105/00 ; B29L31/00 ; C12M3/00 ; C12M1/00 ; C12M1/26
摘要:
A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.