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公开(公告)号:US11318106B2
公开(公告)日:2022-05-03
申请号:US16690558
申请日:2019-11-21
IPC分类号: A61L15/26 , A61K9/70 , A61K31/77 , A61L15/18 , A61L15/64 , A61L26/00 , A61L27/44 , A61L27/58 , A61K38/00
摘要: A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.
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公开(公告)号:US11013825B2
公开(公告)日:2021-05-25
申请号:US15672885
申请日:2017-08-09
发明人: Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC分类号: B29C64/112 , A61L27/38 , A61L27/20 , B29C64/393 , A61L27/22 , A61L27/52 , B29C64/124 , A61L27/26 , C12M3/00 , C12M1/00 , C12M1/26 , A61K35/12 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , B29K105/00 , B29K267/00 , B29L31/00
摘要: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
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公开(公告)号:US10751448B2
公开(公告)日:2020-08-25
申请号:US15542095
申请日:2016-01-11
发明人: Anthony Atala , Gayoung Jeong , James J. Yoo , Sang jin Lee , Young-Joon Seol
IPC分类号: A61L27/60 , A61F2/10 , B33Y80/00 , B33Y70/00 , C08L5/08 , A61L27/20 , C08L89/06 , C12N5/071 , B33Y10/00 , B29C64/106 , A61L27/18 , A61L27/38 , A61L27/52 , G01N33/50 , B29K75/00 , B29K105/00
摘要: Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics. Described herein is an artificial mammalian skin substitute product, comprising: (a) optionally, but in some embodiments preferably, a first (“hypodermis-like”) layer comprising live mammalian adipocytes (e.g., induced pre-adipocytes) in a first hydrogel carrier; (b) a second (“dermis-like”) layer contacting or directly contacting the first layer and comprising live mammalian fibroblast cells and' live mammalian follicle dermal papilla cells in combination in a second hydrogel carrier; (c) a third (“epidermis-like”) layer contacting or directly contacting the second layer (i.e., on the opposite side thereof as the first layer, so that the second layer is sandwiched between the first and third layers when the first layer is present), the third layer comprising live mammalian keratinocytes and live mammalian melanocytes in combination in a third hydrogel carrier.
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公开(公告)号:US09039782B2
公开(公告)日:2015-05-26
申请号:US14256643
申请日:2014-04-18
发明人: Anthony Atala , James J. Yoo , Grace Lim , Sang Jin Lee
IPC分类号: A61F2/28 , A61K38/18 , A61L27/36 , A61L27/38 , A61L27/48 , A61L27/56 , A61L27/58 , A61K35/32 , A61K35/34
CPC分类号: A61F2/28 , A61K35/32 , A61K35/34 , A61K38/18 , A61L27/3604 , A61L27/3817 , A61L27/3821 , A61L27/3826 , A61L27/383 , A61L27/3891 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/02
摘要: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
摘要翻译: 本发明涉及生产允许协调运动的人造复合组织结构的方法。 使用具有足够刚性以提供软骨形成细胞和骨形成细胞的结构支持的生物相容性结构基质。 用肌肉细胞接种的生物相容的柔性基质连接到结构基质上以产生能够协同运动的人造复合组织构建体。
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公开(公告)号:US09005972B2
公开(公告)日:2015-04-14
申请号:US14185090
申请日:2014-02-20
发明人: Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
IPC分类号: A61K9/00 , B41M5/52 , B41M99/00 , C12N11/04 , A61K35/36 , A61L27/38 , A61L27/50 , A61L27/58 , B41J3/407 , C12N11/08 , D01D5/00 , D01F6/62 , A61K35/32 , A61K35/34 , A61F2/06
CPC分类号: A61K9/5089 , A61F2/062 , A61K35/32 , A61K35/34 , A61K35/36 , A61L27/38 , A61L27/50 , A61L27/58 , B33Y80/00 , B41J3/407 , C12N5/0655 , C12N11/04 , C12N11/08 , C12N2533/54 , C12N2533/56 , D01D5/0007 , D01F6/625
摘要: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
摘要翻译: 本文提供了一种用于印刷电池的装置,其包括静电纺丝装置和与其可操作地相关联的喷墨打印装置。 还提供了制备具有种子细胞的可生物降解的支架的方法。 还提供了形成包含一个或多个由基底包封的细胞的微粒的方法,以及形成所述微粒阵列的方法。
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公开(公告)号:US11028502B2
公开(公告)日:2021-06-08
申请号:US16171504
申请日:2018-10-26
发明人: Sang Jin Lee , James J. Yoo , Young Min Ju , Anthony Atala
IPC分类号: D01D5/00 , A61L27/24 , A61K35/44 , C07K16/46 , A61K31/737 , A61K38/36 , A61K38/18 , A61K31/729 , A61K38/39 , C07K16/28 , C07D315/00 , A61K31/728 , D01F6/92 , C07K16/18 , D01F1/10 , D01F6/62 , D01F4/00
摘要: The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and anti-thrombogenic agents on the inner surfaces of their lumens.
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公开(公告)号:US20200238024A1
公开(公告)日:2020-07-30
申请号:US16696738
申请日:2019-11-26
发明人: James J. Yoo , Anthony Atala , Kyle W. Binder , Mohammad Z. Albanna , Weixin Zhao , Dennis Dice , Tao Xu
IPC分类号: A61M11/00 , A61B5/00 , A61B5/107 , A61L27/22 , A61L27/24 , A61L27/38 , A61L27/60 , C12N5/077 , A61M35/00
摘要: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.
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公开(公告)号:US20190127884A1
公开(公告)日:2019-05-02
申请号:US16171504
申请日:2018-10-26
发明人: Sang Jin Lee , James J. Yoo , Young Min Ju , Anthony Atala
IPC分类号: D01D5/00 , A61K35/44 , C07K16/46 , A61L27/24 , A61K31/737 , A61K38/36 , A61K31/728 , A61K31/729 , A61K38/39 , C07K16/28 , C07D315/00 , A61K38/18
摘要: The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and anti-thrombogenic agents on the inner surfaces of their lumens.
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公开(公告)号:US20190038849A1
公开(公告)日:2019-02-07
申请号:US16158808
申请日:2018-10-12
发明人: James J. Yoo , Anthony Atala , Kyle W. Binder , Mohammad Z. Albanna , Weixin Zhao , Dennis Dice , Tao Xu
IPC分类号: A61M11/00 , A61L27/38 , A61L27/60 , A61B5/00 , A61B5/107 , A61L27/22 , C12N5/077 , A61M35/00 , A61L27/24 , A61B34/30 , A61B90/50 , A61B17/00 , A61B17/322 , A61B34/10 , B41J3/407
摘要: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.
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公开(公告)号:US09931434B2
公开(公告)日:2018-04-03
申请号:US14357443
申请日:2012-11-09
申请人: Trustees of Tufts College , University of Pittsburgh—of the Commonwealth System of Higher Education , Wake Forest University Health Sciences
发明人: Evangelia Bellas , Kacey Marra , J. Peter Rubin , David L. Kaplan , James J. Yoo
CPC分类号: A61L27/227 , A61L27/3604 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2430/34 , Y10T428/2982 , C08L89/00
摘要: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
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