- 专利标题: Expansion of alloantigen-reactive regulatory T cells
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申请号: US14382537申请日: 2013-03-01
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公开(公告)号: US09801911B2公开(公告)日: 2017-10-31
- 发明人: Qizhi Tang , Jeffrey A. Bluestone
- 申请人: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 申请人地址: US CA Oakland
- 专利权人: The Regents of the University of California
- 当前专利权人: The Regents of the University of California
- 当前专利权人地址: US CA Oakland
- 代理机构: Morrison & Foerster LLP
- 国际申请: PCT/US2013/028734 WO 20130301
- 国际公布: WO2013/131045 WO 20130906
- 主分类号: C12N5/071
- IPC分类号: C12N5/071 ; C12N5/00 ; C12N5/02 ; A61K35/17 ; A61K31/436 ; A61K31/5377 ; A61K31/573 ; C12N5/0783 ; A61K39/00 ; C12N5/0781
摘要:
The present disclosure relates generally to the manufacture of regulatory T cells (Tregs) for use in immunotherapy. In particular, the present disclosure relates to robust approaches for the expansion of alloantigen-reactive Tregs ex vivo. Alloantigen-reactive Tregs produced in this way are suitable for the induction and/or maintenance of immunologic tolerance in recipients of allogeneic transplants.
公开/授权文献
- US20150110761A1 EXPANSION OF ALLOANTIGEN-REACTIVE REGULATORY T CELLS 公开/授权日:2015-04-23