A parking interlock system and method for a vehicle is provided. The system includes: a safety state information detecting unit, configured to detect safety state information of the vehicle; an operating state information detecting unit, configured to detect operating state information of the vehicle; a brake; a motor; a low voltage controller, connected to the safety state information detecting unit and the brake respectively, and configured to generate a safety state judgment result based on the safety state information of the vehicle; and a motor controller, connected to the safety state information detecting unit and the motor respectively, and configured to control the motor according to the safety state judgment result received from the low voltage controller, and to send the operating state information of the vehicle to the low voltage controller such that the low voltage controller controls the brake according to the operating state information.