- 专利标题： Lov-D acyltransferase mediated acylation
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申请号： US15199095申请日： 2016-06-30
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公开(公告)号： US09909156B2公开(公告)日： 2018-03-06
- 发明人: Steven J. Collier , Ee Ling Teo , Joly Sukumaran , Robert J. Wilson , Junye Xu
- 申请人： Codexis Inc.
- 申请人地址： US CA Redwood City
- 专利权人： Codexis, Inc.
- 当前专利权人： Codexis, Inc.
- 当前专利权人地址： US CA Redwood City
- 代理机构： Codexis, Inc.
- 主分类号： C12P17/06
- IPC分类号： C12P17/06 ; C12P7/62 ; C12N9/10 ; C07K14/00 ; C12N15/52
摘要：
Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
公开/授权文献
- US20160304921A1 LOV-D ACYLTRANSFERASE MEDIATED ACYLATION 公开/授权日：2016-10-20
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