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公开(公告)号：US10428360B2
公开(公告)日：2019-10-01
申请号：US15887646
申请日：2018-02-02
申请人： Codexis Inc.
发明人： Steven J. Collier , Ee Ling Teo , Joly Sukumaran , Robert J. Wilson , Junye Xu
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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公开(公告)号：US20180195053A1
公开(公告)日：2018-07-12
申请号：US15903264
申请日：2018-02-23
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
CPC分类号： C12N9/0073 , C12P11/00 , C12P13/02 , C12P41/002 , C12Y114/13022 , Y02P20/52
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US09399785B2
公开(公告)日：2016-07-26
申请号：US14709026
申请日：2015-05-11
申请人： Codexis Inc.
发明人： Steven J. Collier , Ee Ling Teo , Joly Sukumaran , Robert J. Wilson , Junye Xu
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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公开(公告)号：US09181570B2
公开(公告)日：2015-11-10
申请号：US14465467
申请日：2014-08-21
申请人： Codexis, Inc.
发明人： Lynne Gilson , Steven J. Collier , Joly Sukumaran , Wan Lin Yeo , Oscar Alvizo , Ee Ling Teo , Robert J. Wilson , Junye Xu
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
摘要翻译： 本公开提供了可用于合成治疗重要的他汀类化合物的酰基转移酶。
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公开(公告)号：US20150259718A1
公开(公告)日：2015-09-17
申请号：US14709026
申请日：2015-05-11
申请人： Codexis Inc.
发明人： Steven J. Collier , Ee Ling Teo , Joly Sukumaran , Robert J. Wilson , Junye Xu
IPC分类号： C12P17/06
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
摘要翻译： 提出了使用LovD酰基转移酶，具有酰基的硫酯和（i）硫醇清除剂和/或（ii）沉淀剂对化学底物改进酰化的方法。 还提出了使用（i）活性炭作为硫醇清除剂和/或（ii）氢氧化铵作为沉淀剂来生产辛伐他汀的改进方法。
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公开(公告)号：US12060592B2
公开(公告)日：2024-08-13
申请号：US17089498
申请日：2020-11-04
申请人： Codexis Inc.
发明人： Steven J. Collier , Ee Ling Teo , Joly Sukumaran , Robert J. Wilson , Junye Xu
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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公开(公告)号：US20210198638A1
公开(公告)日：2021-07-01
申请号：US17184427
申请日：2021-02-24
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US11046982B2
公开(公告)日：2021-06-29
申请号：US16784011
申请日：2020-02-06
申请人： Codexis, Inc.
发明人： Lynne Gilson , Steven J. Collier , Joly Sukumaran , Wan Lin Yeo , Oscar Alvizo , Ee Ling Teo , Robert J. Wilson , Junye Xu
摘要： The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
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公开(公告)号：US10781429B2
公开(公告)日：2020-09-22
申请号：US16716239
申请日：2019-12-16
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US20190367956A1
公开(公告)日：2019-12-05
申请号：US16543817
申请日：2019-08-19
申请人： Codexis Inc.
发明人： Steven J. Collier , Ee Ling Teo , Joly Sukumaran , Robert J. Wilson , Junye Xu
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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