Implementations are disclosed for a centralized peripheral access controller (PAC) that is configured to protect one or more peripheral components in a system. In some implementations, the PAC stores data that can be set or cleared by software. The data corresponds to an output signal of the PAC that is routed to a corresponding peripheral component. When the data indicates that the peripheral is “unlocked” the PAC will allow write transfers to registers in the peripheral component. When the data indicates that the peripheral component is “locked” the PAC will refuse write transfers to registers in the peripheral component and terminate with an error.