Compositions for inhibiting the attachment of microbes to a biotic or abiotic surface are disclosed. The compositions include a carrier and an effective amount of an anti-adherent agent. The anti-adherent agents include Cyclopentasiloxane (and) Dimethiconol, sodium polystyrene sulfonate, Acrylates/Vinyl Neodecanoate Crosspolymer, Ammonium Acryloyldimethyltaurate/VP Copolymer, Polyquaternium-22, Hydroxypropyl methylcellulose, Polyquaternium-7, Acrylates/Aminoacrylates/C10-30 Alkyl PEG-20 Itaconate Copolymer and combinations thereof. Various delivery vehicles, such as wipes, may be used to deliver the composition to surfaces.