Invention Grant
- Patent Title: Polymerase compositions and methods of making and using same
-
Application No.: US14970818Application Date: 2015-12-16
-
Publication No.: US09976178B2Publication Date: 2018-05-22
- Inventor: Daniel Mazur , Eileen Tozer , Sihong Chen , Peter Vander Horn , Tommie Lincecum
- Applicant: LIFE TECHNOLOGIES CORPORATION
- Applicant Address: US CA Carlsbad
- Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee Address: US CA Carlsbad
- Agency: Life Technologies Corporation
- Agent Karen R. Zachow
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12Q1/68

Abstract:
The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof, such as modified Taq polymerases, are provided that allow for improved nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having improved thermostability, accuracy, processivity and/or read length as compared to a reference Taq polymerase. In some aspects, the disclosure relates to modified polymerases or biologically active fragments thereof, useful for amplification methods, and in practically illustrative embodiments, emulsion PCR.
Public/Granted literature
- US20160177373A1 POLYMERASE COMPOSITIONS AND METHODS OF MAKING AND USING SAME Public/Granted day:2016-06-23
Information query