- 专利标题： Adenovirus vectors containing cell status-specific response elements and methods of use thereof
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申请号： US12221052申请日： 2008-07-29
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公开(公告)号： USRE42373E1公开(公告)日： 2011-05-17
- 发明人: De Chao Yu , Daniel R. Henderson
- 申请人： De Chao Yu , Daniel R. Henderson
- 专利权人： Cold Genesys, Inc.
- 当前专利权人： Cold Genesys, Inc.
- 代理机构： Stetina Brunda Garred & Brucker
- 主分类号： A01N63/00
- IPC分类号： A01N63/00 ; A61K39/00 ; C12N15/00
摘要：
The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using the vectors.