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10 条记录 (耗时 0.028 秒)

    Human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof
    1.
    发明授权
    Human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof 失效
    人腺激肽释放酶增强剂，包含增强子的载体及其使用方法

    公开(公告)号：US06916918B2

    公开(公告)日：2005-07-12

    申请号：US09875228

    申请日：2001-06-05

    申请人： De Chao Yu ,  Daniel R. Henderson ,  Eric R. Schuur

    发明人： De Chao Yu ,  Daniel R. Henderson ,  Eric R. Schuur

    IPC分类号： A61K48/00 ,  C07K14/075 ,  C12N15/57 ,  C12N15/861 ,  C07H21/04 ,  C12N15/74

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2830/002 ,  C12N2830/008

    摘要： Enhancers which preferentially increase the transcription of cis-linked coding sequences in prostate cells are provided. Methods of using DNA constructs comprising the enhancers to control transcription of heterologous polynucleotides are also provided. Delivery vehicles comprising the enhancers and methods of using the vehicles are also provided. Adenovirus vectors in which one or more genes are under transcriptional control of the enhancers of the invention are also provided. Further provided are methods of using the adenovirus vectors of the invention to confer selective cytotoxicity in mammalian cells.

    摘要翻译： 提供优先增加前列腺细胞中顺式连接编码序列的转录的增强子。 还提供了使用包含增强子的DNA构建体来控制异源多核苷酸转录的方法。 还提供了包含增强剂和使用车辆的方法的输送车辆。 还提供了其中一个或多个基因在本发明的增强子的转录控制下的腺病毒载体。 还提供了使用本发明的腺病毒载体在哺乳动物细胞中赋予选择性细胞毒性的方法。

    Methods of enhancing effectiveness of therapeutic viral immunogenic agent administration
    4.
    发明授权
    Methods of enhancing effectiveness of therapeutic viral immunogenic agent administration 失效
    增强治疗性病毒免疫原性药物给药的有效性的方法

    公开(公告)号：US06406861B1

    公开(公告)日：2002-06-18

    申请号：US09413044

    申请日：1999-10-06

    申请人： Daniel R. Henderson ,  Yu Chen ,  De Chao Yu

    发明人： Daniel R. Henderson ,  Yu Chen ,  De Chao Yu

    IPC分类号： G01N3353

    CPC分类号： A61K48/00 ,  A61M1/3679 ,  Y10S514/885

    摘要： Methods of reducing pre-existing humoral immunity to a viral immunogenic therapeutic agent such as adenovirus, using immunoapheresis are disclosed. Antibodies specific for the viral immunogenic therapeutic agent are selectively removed from the blood of an individual prior to administration of the viral immunogenic therapeutic agent by reaction extracorporeally with an immunosorbent which specifically binds the antibody. After the antibody is selectively removed from the blood, the blood is reinfused into the patient and the viral immunogenic therapeutic agent is administered. The invention also provides kits and compositions for selective removal of anti-viral antibody.

    摘要翻译： 公开了使用免疫分离法减少病毒免疫原性治疗剂如腺病毒的预先存在的体液免疫的方法。 在给予病毒免疫原性治疗剂之前，通过与特异性结合抗体的免疫吸附剂体外反应，选择性地从个体的血液中除去病毒免疫原性治疗剂的特异性抗体。 在从血液中选择性地除去抗体后，将血液再次输注到患者体内，并施用病毒免疫原性治疗剂。 本发明还提供用于选择性除去抗病毒抗体的试剂盒和组合物。

    Target cell-specific adenoviral vectors containing E3 and methods of use thereof
    8.
    发明授权
    Target cell-specific adenoviral vectors containing E3 and methods of use thereof 有权
    含有E3的靶细胞特异性腺病毒载体及其使用方法

    公开(公告)号：US06495130B1

    公开(公告)日：2002-12-17

    申请号：US09474699

    申请日：1999-12-29

    申请人： Daniel R. Henderson ,  De Chao Yu

    发明人： Daniel R. Henderson ,  De Chao Yu

    IPC分类号： A61K35300

    CPC分类号： C12N15/86 ,  C12N2710/10343 ,  C12N2710/10345

    摘要： The invention provides adenoviral vectors (preferably replication competent) comprising both an E3 sequence and at least one adenoviral gene under transcriptional control of a target cell-specific transcriptional response element. These vectors display significantly improved cytotoxicity, which is especially useful in the cancer context, in which selective destruction of target cells is desirable. The invention further provides host cells comprising the vectors. The invention further provides methods of using the adenoviral vectors.

    摘要翻译： 本发明在靶细胞特异性转录应答元件的转录控制下提供包含E3序列和至少一种腺病毒基因的腺病毒载体（优选复制受体）。 这些载体显示出显着改善的细胞毒性，其在癌症背景下特别有用，其中靶细胞的选择性破坏是期望的。 本发明还提供了包含载体的宿主细胞。 本发明还提供了使用腺病毒载体的方法。

    Cell-specific adenovirus vector comprising EBV-specific promoter
    9.
    发明授权
    Cell-specific adenovirus vector comprising EBV-specific promoter 失效
    包含EBV特异性启动子的细胞特异性腺病毒载体

    公开(公告)号：US07371570B2

    公开(公告)日：2008-05-13

    申请号：US10698160

    申请日：2003-10-30

    申请人： De Chao Yu ,  Nagarajan Ramesh

    发明人： De Chao Yu ,  Nagarajan Ramesh

    IPC分类号： C12N15/861 ,  C12N5/10 ,  A61K48/00

    CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K48/00 ,  C07K14/005 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2710/16222 ,  C12N2830/00 ,  C12N2830/205 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2840/203

    摘要： Replication-competent adenoviral vectors comprising an EBV-specific transcriptional regulatory element (TRE) operably linked to a gene required for adenovirus replication are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication can be restricted to particular target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.

    摘要翻译： 提供了包含可操作地连接到腺病毒复制所需的基因的EBV特异性转录调控元件（TRE）的复制能力的腺病毒载体。 通过提供依赖于仅在特定的有限细胞类型中活跃的转录因子的转录起始调节，病毒复制可以限于特定的靶细胞。 修饰的腺病毒可以用作引入新遗传能力的载体，特别是与用于治疗瘤形成的细胞毒性有关。