发明申请
- 专利标题： N-ALKANOYLPHENYLALANINE DERIVATIVES
- 专利标题（中）： N-烷酰基苯基丙氨酸衍生物
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申请号： PCT/EP9805135申请日： 1998-08-13
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公开(公告)号： WO9910312B1公开(公告)日： 1999-06-03
- 发明人: CHEN LI , GUTHRIE ROBERT WILLIAM , HUANG TAI-NANG , HULL KENNETH G , SIDDURI ACHYTHARAO , TILLEY JEFFERSON WRIGHT
- 申请人： HOFFMANN LA ROCHE
- 专利权人： HOFFMANN LA ROCHE
- 当前专利权人： HOFFMANN LA ROCHE
- 优先权： US5671897 1997-08-22
- 主分类号： A61K31/165
- IPC分类号： A61K31/165 ; A61K31/198 ; A61K31/216 ; A61K31/27 ; A61K31/277 ; A61K31/33 ; A61K31/41 ; A61K31/4192 ; A61K31/42 ; A61K31/426 ; A61K31/437 ; A61K31/44 ; A61K31/4418 ; A61K31/47 ; A61K31/496 ; A61K31/505 ; A61K31/519 ; A61K31/66 ; A61P1/00 ; A61P11/06 ; A61P19/02 ; A61P25/00 ; A61P29/00 ; C07C233/87 ; C07C235/52 ; C07C235/84 ; C07C237/22 ; C07C237/36 ; C07C275/42 ; C07C311/17 ; C07C311/21 ; C07C317/44 ; C07C317/50 ; C07C323/39 ; C07C323/62 ; C07D211/64 ; C07D213/82 ; C07D215/30 ; C07D215/50 ; C07D233/32 ; C07D233/36 ; C07D233/74 ; C07D233/80 ; C07D239/28 ; C07D249/06 ; C07D257/06 ; C07D261/18 ; C07D277/20 ; C07D277/56 ; C07D295/08 ; C07D295/14 ; C07D295/15 ; C07D401/12 ; C07D413/12 ; C07D471/04 ; C07D487/04 ; C07D295/088
摘要：
Compounds of formula (1) as well as their salts and esters are disclosed wherein X, X', Z and Y are as described in the specification and which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
