公开(公告)号：WO2022047288A1

公开(公告)日：2022-03-03

申请号：PCT/US2021/048187

申请日：2021-08-30

Applicant: INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER

Inventor： BELLACOSA, Alfonso ,  KARANICOLAS, John ,  YEN, Timothy J. ,  CORY, Michael ,  PARRY, Chris ,  PRASAD, Rahul

IPC: A61P35/00 ,  C07C311/21 ,  C07C311/39 ,  C07C311/43

Abstract: Phenylsulfonamido compounds that inhibit genome-wide hypomethylation and can be used to treat cancer, including melanoma, prostate cancer, pancreatic cancer, breast cancer, colon cancer, lung cancer, ovarian cancer, and glioblastoma, are provided.

公开(公告)号：WO2021226149A1

公开(公告)日：2021-11-11

申请号：PCT/US2021/030741

申请日：2021-05-04

Applicant: MISSISSIPPI STATE UNIVERSITY

Inventor： CUI, Xin ,  LI, Zhong-Yuan ,  CHAMINDA LAKMAL, Hetti Handi

IPC: C07D209/10 ,  C07D209/92 ,  C07C311/21 ,  C07C311/29 ,  C07F7/18 ,  C07C47/575 ,  B01J31/28

Abstract: Provided herein are a method of Ru(II)-catalyzed enantioselective synthesis of a cyclic compound and cyclic compounds formed therefrom. The method includes providing a precursor compound having an unfunctionalized C-H bond and activating the unfunctionalized C-H bond by reacting the precursor compound in the presence of co-catalysts including a Ru(II) arene complex and a chiral transient directing group (CTDG).

公开(公告)号：WO2021099842A1

公开(公告)日：2021-05-27

申请号：PCT/IB2020/000981

申请日：2020-11-20

Applicant: 2692372 ONTARIO INC. ,  DUNAD THERAPEUTICS LTD.

Inventor： KRASKOUSKAYA, Dziyana ,  AHMAR, Siawash ,  GUNNING, Patrick, T. ,  OMEARA, Jeff ,  ROSA, David Alexander ,  PARK, Ji Sung ,  SIMPSON, Graham L. ,  ABDELDAYEM, Ayah

IPC: C07D487/04 ,  A61K31/18 ,  A61K31/357 ,  A61K31/395 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4462 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/55 ,  A61K47/54 ,  C07C311/21 ,  C07C381/10 ,  C07D209/08 ,  C07D209/44 ,  C07D211/08 ,  C07D231/06 ,  C07D233/66 ,  C07D239/48 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D405/14 ,  C07D471/04 ,  C07D471/14 ,  C07K1/107 ,  C12N9/12

Abstract: Provided herein are pentafluorobenzenesulfonamide compounds of Formula (I), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases. These compounds are covalent small molecule inhibitors, more specifically inhibitors of tubulin polymerization.

公开(公告)号：WO2021041866A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/048482

申请日：2020-08-28

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

Inventor： XU, Haoxing ,  YU, Lu ,  MARUGAN, Juan Jose ,  CALVO, Raul Rolando ,  MARTINEZ, Natalia Julia ,  SOUTHALL, Noel Terrence ,  FERRER, Marc ,  HU, Xin

IPC: A61K31/18 ,  A61K31/445 ,  C07C311/21 ,  A61P21/00

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a phenyl-sulfonic amide (or similar) structure which function as agonists of mucolipin 1 (ML1), and their use as therapeutics for the treatment of Duchenne muscular dystrophy (DMD) and related disorders.

公开(公告)号：WO2020168290A1

公开(公告)日：2020-08-20

申请号：PCT/US2020/018431

申请日：2020-02-14

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION ,  YALE UNIVERSITY

Inventor： WATT, David S. ,  GEDALY, Roberto ,  SPEAR, Brett T. ,  YANG-HARTWICH, Yang ,  LIU, Chunming ,  MARTI, Francesc ,  SULLIVAN, Patrick ,  ZHANG, Wen

IPC: A61K31/18 ,  C07C311/21 ,  C07D413/12

Abstract: Provided herein are methods for treating a disease, such as cancer, the methods including administering one or more N -aryl benezenesulfonamides or analogs thereof to a subject in need thereof.

公开(公告)号：WO2020127675A1

公开(公告)日：2020-06-25

申请号：PCT/EP2019/086224

申请日：2019-12-19

Applicant: PAPIERFABRIK AUGUST KOEHLER SE

Inventor： HORN, Michael ,  STALLING, Timo

IPC: B41M5/333 ,  C07C311/15 ,  C07C311/21 ,  C07C317/14 ,  C07C317/26 ,  B41M5/327 ,  B41M5/337

Abstract: Beschrieben werden Farbentwickler der Formel (I) Ar 1 -SO 2 -NH-C 6 H 4 -SO 2 -C 6 H 4 -NH-CO-NH-Ar 2 (I), ein wärmeempfindliches Aufzeichnungsmaterial, umfassend ein Trägersubstrat sowie mindestens einen Farbbildner und mindestens einen phenolfreien Farbentwickler enthaltende wärmeempfindliche farbbildende Schicht, wobei der mindestens eine Farbentwickler die Verbindung der Formel (I) ist, und ein Verfahren zur Herstellung dieses wärmeempfindlichen Aufzeichnungsmaterials.

公开(公告)号：WO2019226490A1

公开(公告)日：2019-11-28

申请号：PCT/US2019/032925

申请日：2019-05-17

Applicant: GILEAD SCIENCES, INC.

Inventor： FARAND, Julie ,  KAPLAN, Joshua A. ,  NOTTE, Gregory ,  OLEN, Casey Lockwood ,  SANGI, Michael ,  SPERANDIO, David

IPC: C07D213/71 ,  C07D309/08 ,  C07D231/18 ,  C07D233/20 ,  C07D335/02 ,  C07C311/08 ,  C07C311/14 ,  C07C311/21 ,  C07C311/29 ,  C07C311/39 ,  C07C311/46 ,  C07C317/14 ,  C07D239/26 ,  C07D257/04 ,  C07D275/02 ,  C07D277/36 ,  C07D279/12 ,  C07D305/06 ,  A61P1/16 ,  C07F9/46 ,  C07D451/14 ,  C07D205/04 ,  C07D493/08 ,  C07D295/26

Abstract: Provided is a compound of Formula (I), wherein the variable groups are defined herein.

公开(公告)号：WO2018212368A1

公开(公告)日：2018-11-22

申请号：PCT/KR2017/005061

申请日：2017-05-16

Applicant: 연세대학교 산학협력단 ,  이화여자대학교 산학협력단

Inventor： 김어수 ,  남궁기 ,  정지현 ,  장수아 ,  권영주 ,  전규연 ,  전경화

IPC: C07C225/22 ,  C07C311/21 ,  C07D211/14 ,  C07D241/04 ,  A61K31/136 ,  A61K31/18 ,  A61K31/496

Abstract: 본 발명은 신규 화합물 및 상기 화합물을 유효성분으로 포함하는 퇴행성 신경질환의 예방 또는 치료용 약학 조성물에 관한 것으로, 에이엠피-활성 단백질 키나아제 활성 효능 및 인 실리코상 결합능이 좋은 모체 구조에서 화학적 변형(chemical modification)을 진행하여 얻어진 신규 화합물은 에이엠피-활성 단백질 키나아제(AMP-activated protein kinase;AMPK) 효소 활성화를 효과적으로 유도하여 퇴행성 신경질환을 효과적으로 예방 또는 치료할 수 있다.

公开(公告)号：WO2018029699A1

公开(公告)日：2018-02-15

申请号：PCT/IN2017/000114

申请日：2017-08-11

Applicant: MSN RESEARCH & DEVELOPMENT CENTER ,  THIRUMALAI RAJAN, Srinivasan ,  ESWARAIAH, Sajja ,  MADHUSUDHAN, Gutta ,  RAJESHWAR REDDY, Sagyam ,  SATYANARAYANA, Revu ,  RAJESHAM, Boge ,  SRINIVASA RAO, Ambati

Inventor： THIRUMALAI RAJAN, Srinivasan ,  ESWARAIAH, Sajja ,  MADHUSUDHAN, Gutta ,  RAJESHWAR REDDY, Sagyam ,  SATYANARAYANA, Revu ,  RAJESHAM, Boge ,  SRINIVASA RAO, Ambati

IPC: C07C311/15 ,  C07C311/21 ,  C07C311/45 ,  C07C303/40 ,  A61K9/10 ,  A61K31/18

CPC classification number: A61K9/146 ,  C07B2200/13 ,  C07C201/12 ,  C07C227/04 ,  C07C303/02 ,  C07C303/38 ,  C07C303/40 ,  C07C303/44 ,  C07C311/21 ,  C07C205/56 ,  C07C229/44 ,  C07C309/89

Abstract: The Present invention relates to solid state forms of (2E)-N-hydroxy-3-[3-(N-phenyl sulfamoyl)phenyl]prop-2-enamide represented by the following structural formula-1 and process for the preparation thereof.

Abstract translation: 本发明涉及由以下结构式表示的（2E）-N-羟基-3- [3-（N-苯基氨磺酰基）苯基]丙-2-烯酰胺的固态形式： 1及其制备方法。

公开(公告)号：WO2017011323A1

公开(公告)日：2017-01-19

申请号：PCT/US2016/041577

申请日：2016-07-08

Applicant: UNIVERSITY OF MARYLAND, BALTIMORE

Inventor： FLETCHER, Steven ,  LANNING, Maryanna ,  CHEN, Lijia

IPC: C07C311/21 ,  A61K31/381

CPC classification number: C07C311/21 ,  C07C229/64 ,  C07C311/29 ,  C07C311/51 ,  C07C2601/08 ,  C07D215/58 ,  C07D257/02 ,  C07D261/12 ,  C07D309/04

Abstract: Compounds that inhibit Myeloid Cell Leukemia-1 (Mcl-1) oncoprotein, and methods of using the same, are provided for treating disease.

Abstract translation: 提供抑制骨髓细胞白血病-1（Mcl-1）癌蛋白的化合物及其使用方法用于治疗疾病。