发明申请
- 专利标题： 2-AMINO- AND 2-THIO-SUBSTITUTED 1,3-DIAMINOPROPANES
- 专利标题（中）： 2-氨基和2-取代的1,3-二氨基吡啶
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申请号： PCT/US2005009920申请日： 2005-03-25
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公开(公告)号： WO2005095326A3公开(公告)日： 2005-11-10
- 发明人: HOM ROY , TUCKER JOHN , JOHN VARGHESE , SHAH NEERAV
- 申请人： ELAN PHARM INC , PHARMACIA & UP JOHN COMPANY , HOM ROY , TUCKER JOHN , JOHN VARGHESE , SHAH NEERAV
- 专利权人： ELAN PHARM INC,PHARMACIA & UP JOHN COMPANY,HOM ROY,TUCKER JOHN,JOHN VARGHESE,SHAH NEERAV
- 当前专利权人： ELAN PHARM INC,PHARMACIA & UP JOHN COMPANY,HOM ROY,TUCKER JOHN,JOHN VARGHESE,SHAH NEERAV
- 优先权： US55646104 2004-03-25
- 主分类号： A61K31/16
- IPC分类号： A61K31/16 ; A61K31/353 ; A61K31/382 ; A61K31/47 ; C07C233/36 ; C07C235/10 ; C07C271/24 ; C07C311/05 ; C07C323/41 ; C07C327/42 ; C07D213/38 ; C07D215/38 ; C07D215/46 ; C07D303/36 ; C07D307/52 ; C07D311/68 ; C07D311/76 ; C07D317/72 ; C07D333/20 ; C07D335/04 ; C07D335/06 ; C07D405/04 ; A61K31/10 ; A61K31/165 ; A61P25/28
摘要：
Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
公开/授权文献
- WO2005095326A8 2-AMINO- AND 2-THIO-SUBSTITUTED 1,3-DIAMINOPROPANES 公开/授权日：2006-10-12
