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公开(公告)号：WO2005087752A8
公开(公告)日：2006-12-28
申请号：PCT/US2005007773
申请日：2005-03-09
申请人： ELAN PHARM INC , JOHN VARGHESE , MAILLARD MICHEL , TUCKER JOHN , JAGODZINSKA BARBARA , BROGLEY LOUIS , TUNG JAY , SHAH NEERAV , NEITZ R JEFFREY
发明人： JOHN VARGHESE , MAILLARD MICHEL , TUCKER JOHN , JAGODZINSKA BARBARA , BROGLEY LOUIS , TUNG JAY , SHAH NEERAV , NEITZ R JEFFREY
IPC分类号： A61K31/433 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4747 , A61K31/4965 , A61P25/28 , C07C215/68 , C07C215/70 , C07C237/20 , C07D233/54 , C07D257/04 , C07D263/32 , C07D285/00 , C07D285/12 , C07D285/135 , C07D333/20 , C07D333/24 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/12
CPC分类号： C07D333/24 , C07C211/40 , C07C215/44 , C07C215/70 , C07C237/20 , C07C2601/14 , C07C2602/10 , C07D233/64 , C07D257/04 , C07D263/32 , C07D285/08 , C07D285/135 , C07D333/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/12
摘要： The invention relates to novel aminoalkanol derivatives and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及新的氨基链烷醇衍生物，还涉及使用这些化合物治疗与淀粉样变性相关的至少一种疾病，病症或病症的方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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公开(公告)号：WO2005095326A8
公开(公告)日：2006-10-12
申请号：PCT/US2005009920
申请日：2005-03-25
申请人： ELAN PHARM INC , PHARMACIA & UP JOHN COMPANY LL , HOM ROY , TUCKER JOHN , JOHN VARGHESE , SHAH NEERAV
发明人： HOM ROY , TUCKER JOHN , JOHN VARGHESE , SHAH NEERAV
IPC分类号： C07C233/36 , A61K31/16 , A61K31/353 , A61K31/382 , A61K31/47 , C07C235/10 , C07C271/24 , C07C311/05 , C07C323/41 , C07C327/42 , C07D213/38 , C07D215/38 , C07D215/46 , C07D303/36 , C07D307/52 , C07D311/68 , C07D311/76 , C07D317/72 , C07D333/20 , C07D335/04 , C07D335/06 , C07D405/04
CPC分类号： C07C327/42 , C07B2200/07 , C07C233/36 , C07C235/10 , C07C271/24 , C07C311/05 , C07C323/41 , C07C2601/02 , C07C2601/14 , C07C2602/10 , C07D213/38 , C07D215/38 , C07D215/46 , C07D303/36 , C07D307/52 , C07D311/68 , C07D311/76 , C07D317/72 , C07D333/20 , C07D335/06 , C07D405/04
摘要： Disclosed are compounds of the formula: where variables Q, Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
摘要翻译： 公开了下式的化合物：其中变量Q，Z，X，R 15，R 2，R 3和R 3， 本文定义。 本文公开的化合物是β-分泌酶的抑制剂，因此可用于治疗阿尔茨海默氏病和以哺乳动物中Aβ肽沉积为特征的其它疾病。
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公开(公告)号：WO2005087751A3
公开(公告)日：2005-12-15
申请号：PCT/US2005007771
申请日：2005-03-09
申请人： ELAN PHARM INC , JOHN VARGHESE , MAILLARD MICHEL , TUCKER JOHN , AQUINO JOSE , JAGODZINSKA BARBARA , BROGLEY LOUIS , TUNG JAY , BOWERS SIMEON , DRESSEN DARREN , PROBST GARY , SHAH NEERAV
发明人： JOHN VARGHESE , MAILLARD MICHEL , TUCKER JOHN , AQUINO JOSE , JAGODZINSKA BARBARA , BROGLEY LOUIS , TUNG JAY , BOWERS SIMEON , DRESSEN DARREN , PROBST GARY , SHAH NEERAV
IPC分类号： A61K31/382 , A61K31/453 , C07D207/32 , C07D207/325 , C07D233/54 , C07D257/04 , C07D335/06 , C07D403/12 , C07D405/12 , C07D419/12 , C07D233/61 , C07D409/12 , C07D413/12
CPC分类号： C07D419/12 , C07C215/28 , C07C215/50 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/58 , C07C225/06 , C07C225/20 , C07C229/16 , C07C229/42 , C07C229/60 , C07C233/43 , C07C237/20 , C07C237/30 , C07C271/12 , C07C311/24 , C07C317/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/04 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D207/323 , C07D207/325 , C07D213/38 , C07D215/42 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D239/48 , C07D249/04 , C07D249/06 , C07D249/14 , C07D257/04 , C07D263/34 , C07D271/113 , C07D275/02 , C07D277/42 , C07D285/08 , C07D285/10 , C07D285/135 , C07D307/52 , C07D309/14 , C07D311/74 , C07D333/36 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及新化合物，还涉及使用这些化合物治疗与淀粉样变性相关的至少一种疾病，病症或病症的方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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公开(公告)号：WO2005087752A3
公开(公告)日：2006-04-13
申请号：PCT/US2005007773
申请日：2005-03-09
申请人： ELAN PHARM INC , JOHN VARGHESE , MAILLARD MICHEL , TUCKER JOHN , JAGODZINSKA BARBARA , BROGLEY LOUIS , TUNG JAY , SHAH NEERAV , NEITZ R JEFFREY
发明人： JOHN VARGHESE , MAILLARD MICHEL , TUCKER JOHN , JAGODZINSKA BARBARA , BROGLEY LOUIS , TUNG JAY , SHAH NEERAV , NEITZ R JEFFREY
IPC分类号： C07D285/12 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4747 , A61K31/4965 , A61P25/28 , C07C215/68 , C07C215/70 , C07C237/20 , C07D233/54 , C07D257/04 , C07D263/32 , C07D285/00 , C07D285/135 , C07D333/20 , C07D333/24 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/12
CPC分类号： C07D333/24 , C07C211/40 , C07C215/44 , C07C215/70 , C07C237/20 , C07C2601/14 , C07C2602/10 , C07D233/64 , C07D257/04 , C07D263/32 , C07D285/08 , C07D285/135 , C07D333/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/12
摘要： The invention relates to novel aminoalkanol derivatives and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及新型氨基链烷醇衍生物，并且还涉及使用这些化合物治疗与淀粉样变性相关的至少一种疾病，病症或病症的方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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公开(公告)号：WO2005095326A3
公开(公告)日：2005-11-10
申请号：PCT/US2005009920
申请日：2005-03-25
申请人： ELAN PHARM INC , PHARMACIA & UP JOHN COMPANY , HOM ROY , TUCKER JOHN , JOHN VARGHESE , SHAH NEERAV
发明人： HOM ROY , TUCKER JOHN , JOHN VARGHESE , SHAH NEERAV
IPC分类号： A61K31/16 , A61K31/353 , A61K31/382 , A61K31/47 , C07C233/36 , C07C235/10 , C07C271/24 , C07C311/05 , C07C323/41 , C07C327/42 , C07D213/38 , C07D215/38 , C07D215/46 , C07D303/36 , C07D307/52 , C07D311/68 , C07D311/76 , C07D317/72 , C07D333/20 , C07D335/04 , C07D335/06 , C07D405/04 , A61K31/10 , A61K31/165 , A61P25/28
CPC分类号： C07C327/42 , C07B2200/07 , C07C233/36 , C07C235/10 , C07C271/24 , C07C311/05 , C07C323/41 , C07C2601/02 , C07C2601/14 , C07C2602/10 , C07D213/38 , C07D215/38 , C07D215/46 , C07D303/36 , C07D307/52 , C07D311/68 , C07D311/76 , C07D317/72 , C07D333/20 , C07D335/06 , C07D405/04
摘要： Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
摘要翻译： 公开了下式的化合物：其中变量Q，Z，X，R 15，R 2，R 3和R c在本文中定义。 本文公开的化合物是β-分泌酶的抑制剂，因此可用于治疗阿尔茨海默氏病和以哺乳动物中Aβ肽沉积为特征的其它疾病。
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公开(公告)号：WO2005095326A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/009920
申请日：2005-03-25
申请人： ELAN PHARMACEUTICALS, INC. , PHARMACIA & UP JOHN COMPANY , HOM, Roy , TUCKER, John , JOHN, Varghese , SHAH, Neerav
发明人： HOM, Roy , TUCKER, John , JOHN, Varghese , SHAH, Neerav
IPC分类号： C07C233/00
CPC分类号： C07C327/42 , C07B2200/07 , C07C233/36 , C07C235/10 , C07C271/24 , C07C311/05 , C07C323/41 , C07C2601/02 , C07C2601/14 , C07C2602/10 , C07D213/38 , C07D215/38 , C07D215/46 , C07D303/36 , C07D307/52 , C07D311/68 , C07D311/76 , C07D317/72 , C07D333/20 , C07D335/06 , C07D405/04
摘要： Disclosed are compounds of the formula: where variables Q, Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer’s disease and other diseases characterized by deposition of A beta peptide in a mammal.
摘要翻译： 公开了下式的化合物：其中变量Q，Z，X，R 15，R 2，R 3， 在此定义了R c和R c。 本文公开的化合物是β-分泌酶的抑制剂，因此可用于治疗阿尔茨海默氏病和以Aβ肽在哺乳动物中沉积为特征的其他疾病。
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公开(公告)号：WO2005087752A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007773
申请日：2005-03-09
申请人： ELAN PHARMACEUTICALS, INC. , JOHN, Varghese , MAILLARD, Michel , TUCKER, John , JAGODZINSKA, Barbara , BROGLEY, Louis , TUNG, Jay , SHAH, Neerav , NEITZ, R., Jeffrey
发明人： JOHN, Varghese , MAILLARD, Michel , TUCKER, John , JAGODZINSKA, Barbara , BROGLEY, Louis , TUNG, Jay , SHAH, Neerav , NEITZ, R., Jeffrey
IPC分类号： C07D285/00
CPC分类号： C07D333/24 , C07C211/40 , C07C215/44 , C07C215/70 , C07C237/20 , C07C2601/14 , C07C2602/10 , C07D233/64 , C07D257/04 , C07D263/32 , C07D285/08 , C07D285/135 , C07D333/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/12
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
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公开(公告)号：WO2005087751A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007771
申请日：2005-03-09
申请人： ELAN PHARMACEUTICALS, INC. , JOHN, Varghese , MAILLARD, Michel , TUCKER, John , AQUINO, Jose , JAGODZINSKA, Barbara , BROGLEY, Louis , TUNG, Jay , BOWERS, Simeon , DRESSEN, Darren , PROBST, Gary , SHAH, Neerav
发明人： JOHN, Varghese , MAILLARD, Michel , TUCKER, John , AQUINO, Jose , JAGODZINSKA, Barbara , BROGLEY, Louis , TUNG, Jay , BOWERS, Simeon , DRESSEN, Darren , PROBST, Gary , SHAH, Neerav
IPC分类号： C07D257/04
CPC分类号： C07D419/12 , C07C215/28 , C07C215/50 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/58 , C07C225/06 , C07C225/20 , C07C229/16 , C07C229/42 , C07C229/60 , C07C233/43 , C07C237/20 , C07C237/30 , C07C271/12 , C07C311/24 , C07C317/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/04 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D207/323 , C07D207/325 , C07D213/38 , C07D215/42 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D239/48 , C07D249/04 , C07D249/06 , C07D249/14 , C07D257/04 , C07D263/34 , C07D271/113 , C07D275/02 , C07D277/42 , C07D285/08 , C07D285/10 , C07D285/135 , C07D307/52 , C07D309/14 , C07D311/74 , C07D333/36 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及新化合物，还涉及使用这些化合物治疗至少一种与淀粉样变性相关的疾病，病症或病症的方法。 淀粉样变性是指与A-β蛋白异常沉积有关的疾病，病症和病症的集合。
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9.发明申请SUBSTITUTED UREA AND CARBAMATE, PHENACYL-2-HYDROXY-3-DIAMINOALKANE, AND BENZAMIDE-2-HYDROXY-3-DIAMINOALKANE ASPARTYL-PROTEASE INHIBITORS 审中-公开取代的尿素和卡巴酸盐，PHENACYL-2-羟基-3-二氨基壬酸和苯甲酰-2-羟基-3-二氨基甘氨酸ASPARTYL-PROTEASE抑制剂
公开(公告)号：WO2005087215A1
公开(公告)日：2005-09-22
申请号：PCT/US2005/007775
申请日：2005-03-09
申请人： ELAN PHARMACEUTICALS, INC. , JOHN, Varghese , MAILLARD, Michel , TUCKER, John , AQUINO, Jose , HOM, Roy , TUNG, Jay , DRESSEN, Darren , SHAH, Neerav , NEITZ, R., Jeffrey
发明人： JOHN, Varghese , MAILLARD, Michel , TUCKER, John , AQUINO, Jose , HOM, Roy , TUNG, Jay , DRESSEN, Darren , SHAH, Neerav , NEITZ, R., Jeffrey
IPC分类号： A61K31/16
CPC分类号： C07D335/06 , A61K31/16 , C07C215/28 , C07C229/42 , C07C229/60 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/74 , C07C235/82 , C07C237/30 , C07C239/16 , C07C255/34 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/26 , C07C311/03 , C07C311/05 , C07C311/07 , C07C311/08 , C07C323/30 , C07C323/59 , C07C327/46 , C07C2601/02 , C07C2601/10 , C07C2601/14 , C07C2602/10 , C07C2603/74 , C07D205/04 , C07D207/16 , C07D207/28 , C07D209/12 , C07D209/18 , C07D209/42 , C07D211/56 , C07D211/58 , C07D211/94 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/30 , C07D233/46 , C07D233/58 , C07D233/64 , C07D233/76 , C07D233/90 , C07D239/26 , C07D241/24 , C07D257/04 , C07D261/08 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/14 , C07D277/24 , C07D277/28 , C07D277/56 , C07D307/00 , C07D307/24 , C07D307/54 , C07D307/68 , C07D309/14 , C07D311/96 , C07D317/72 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D405/10 , C07D407/12 , C07F9/4006
摘要： The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and condition associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及可用于治疗与淀粉样变性相关的至少一种疾病，病症和病症的乙酰基2-羟基-1,3-二氨基螺环己烷及其衍生物。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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