Invention Application
- Patent Title: DEVICE AND METHOD FOR SORTING BIOLOGICAL CELLS
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Application No.: PCT/US2022/029026Application Date: 2022-05-12
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Publication No.: WO2022241138A1Publication Date: 2022-11-17
- Inventor: PEUMANS, Peter , TULLOCH, Alexander , HENRY, Olivier , VAN ROY, Willem , STAKENBORG, Tim
- Applicant: JANSSEN BIOTECH, INC. , IMEC VZW
- Applicant Address: 800/850 Ridgeview Drive; Kapeldreef 75
- Assignee: JANSSEN BIOTECH, INC.,IMEC VZW
- Current Assignee: JANSSEN BIOTECH, INC.,IMEC VZW
- Current Assignee Address: 800/850 Ridgeview Drive; Kapeldreef 75
- Agency: MACHADO, Edward
- Priority: US63/188,314 2021-05-13
- Main IPC: C12M1/00
- IPC: C12M1/00 ; B01L3/00 ; G01N15/14 ; B01L2200/0652 ; B01L2300/0816 ; B01L2300/0864 ; B01L2300/16 ; B01L2400/086 ; B01L2400/088 ; B01L3/502715 ; B01L3/502746 ; B01L3/502761 ; C12M35/04 ; C12M47/04 ; G01N15/147 ; G01N2015/1006 ; G01N2015/1454 ; G01N2015/149 ; G03H1/00
Abstract:
A device for sorting biological cells comprises a flow channel configured to pass a flow of liquid carrying the biological ceils. The flow channel comprises at least one zone associated with a cell category. Each zone of the flow channel comprises at least one surface coated with molecules having an affinity to the cell category associated with the zone, the at least one surface of the zone being configured to modify, by the molecules of the surface, a movement of a cell belonging to the associated cell category of the zone as the cell passes the zone. The device comprises a detector configured to detect a cell exhibiting at least one modified movement in one zone of the flow channel, and to transmit a trigger signal based on the detection of the cell. The device further comprises an actuator configured to divert the detected cell based on the trigger signal.
Information query