公开(公告)号：WO2022241138A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/029026

申请日：2022-05-12

Applicant: JANSSEN BIOTECH, INC. ,  IMEC VZW

Inventor： PEUMANS, Peter ,  TULLOCH, Alexander ,  HENRY, Olivier ,  VAN ROY, Willem ,  STAKENBORG, Tim

IPC: C12M1/00 ,  B01L3/00 ,  G01N15/14 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/16 ,  B01L2400/086 ,  B01L2400/088 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502761 ,  C12M35/04 ,  C12M47/04 ,  G01N15/147 ,  G01N2015/1006 ,  G01N2015/1454 ,  G01N2015/149 ,  G03H1/00

Abstract: A device for sorting biological cells comprises a flow channel configured to pass a flow of liquid carrying the biological ceils. The flow channel comprises at least one zone associated with a cell category. Each zone of the flow channel comprises at least one surface coated with molecules having an affinity to the cell category associated with the zone, the at least one surface of the zone being configured to modify, by the molecules of the surface, a movement of a cell belonging to the associated cell category of the zone as the cell passes the zone. The device comprises a detector configured to detect a cell exhibiting at least one modified movement in one zone of the flow channel, and to transmit a trigger signal based on the detection of the cell. The device further comprises an actuator configured to divert the detected cell based on the trigger signal.