SPATIALLY VARIABLE DIELECTRIC LAYERS FOR DIGITAL MICROFLUIDICS

    公开(公告)号:WO2021146573A1

    公开(公告)日:2021-07-22

    申请号:PCT/US2021/013659

    申请日:2021-01-15

    Abstract: A digital microfluidic device including an active matrix of propulsion electrodes controlled by thin-film-transistors. The device includes at least two areas of different propulsion electrode densities. One area may be driven by directly-driving the propulsion electrodes from a power supply or function generator. In the first, higher density region; a first dielectric layer covers the propulsion electrodes. The first dielectric layer has a first dielectric constant and a first thickness. In the second, lower density region, a second dielectric layer has a second dielectric constant and a second thickness covering the propulsion electrodes.

    SAMPLE COLLECTION CONTAINERS, PROCESSES AND COLLECTED SAMPLES

    公开(公告)号:WO2022036174A1

    公开(公告)日:2022-02-17

    申请号:PCT/US2021/045874

    申请日:2021-08-13

    Applicant: STRECK, INC.

    Abstract: The present teachings relate to a method of making a biological sample collection container, an internally coated biological sample collection container, and uses of the same, particularly for omic analysis. A reagent (or a reagent precursor) is deposited in a liquid state at least partially along at least one side wall of the container. The reagent precursor is dried to form a dried coating having a predefined pattern and topology along at least a portion of the at least one side wall. A container thus results having a coating that includes, in a dried state, a stabilizer agent, or reaction product of a stabilizer agent and an anticoagulant, and upon collection of a sample enables stabilization of any present white blood cells, cell-free nucleic acids, extracellular vesicles, circulating tumor cells, proteins, metabolites, lipids, or any combination thereof, and preserving them in sufficient quantity and quality for omic analysis.

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