公开(公告)号：WO2022241138A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/029026

申请日：2022-05-12

Applicant: JANSSEN BIOTECH, INC. ,  IMEC VZW

Inventor： PEUMANS, Peter ,  TULLOCH, Alexander ,  HENRY, Olivier ,  VAN ROY, Willem ,  STAKENBORG, Tim

IPC: C12M1/00 ,  B01L3/00 ,  G01N15/14 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/16 ,  B01L2400/086 ,  B01L2400/088 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502761 ,  C12M35/04 ,  C12M47/04 ,  G01N15/147 ,  G01N2015/1006 ,  G01N2015/1454 ,  G01N2015/149 ,  G03H1/00

Abstract: A device for sorting biological cells comprises a flow channel configured to pass a flow of liquid carrying the biological ceils. The flow channel comprises at least one zone associated with a cell category. Each zone of the flow channel comprises at least one surface coated with molecules having an affinity to the cell category associated with the zone, the at least one surface of the zone being configured to modify, by the molecules of the surface, a movement of a cell belonging to the associated cell category of the zone as the cell passes the zone. The device comprises a detector configured to detect a cell exhibiting at least one modified movement in one zone of the flow channel, and to transmit a trigger signal based on the detection of the cell. The device further comprises an actuator configured to divert the detected cell based on the trigger signal.

公开(公告)号：WO2017001534A1

公开(公告)日：2017-01-05

申请号：PCT/EP2016/065229

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： PEUMANS, Peter ,  LAGAE, Liesbet ,  VAN ROY, Willem ,  STAKENBORG, Tim ,  VAN DORPE, Pol

IPC: G01N21/64 ,  G01N21/27

CPC classification number: G01N21/6408 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/6413 ,  G01N2021/6439

Abstract: A sensor device (100) for quantifying luminescent targets. The device comprises a light source (111) for exciting the targets, thus generating luminescence signals and a detector (120) for detecting these signals, resulting in a detected signal which comprises a desired signal (310) originating from the targets and a background signal (320). It moreover comprises a bleaching device (135) for bleaching of at least part of the sources generating the background signal (320) and a processor (140) configured to trigger the bleaching device (135) to start bleaching, and to trigger the light source (111) for exciting the remaining luminescent targets which are not bleached, and to trigger the detector (120) for detecting the luminescence signal of the remaining luminescent targets, so as to generate a measurement signal representative for the quantification of the luminescent targets.

Abstract translation: 一种用于量化发光靶的传感器装置（100）。 该装置包括用于激发目标的光源（111），从而产生发光信号，以及用于检测这些信号的检测器（120），产生检测信号，该检测信号包括源自目标的期望信号（310）和背景信号 （320）。 它还包括漂白装置（135），用于漂白产生背景信号的源的至少一部分（320）和配置成触发漂白装置（135）开始漂白的处理器（140），并触发光源 （111），用于激发未漂白的剩余发光靶，并且触发检测器（120）以检测剩余的发光靶的发光信号，以产生代表发光靶的量化的测量信号。

公开(公告)号：WO2017001536A1

公开(公告)日：2017-01-05

申请号：PCT/EP2016/065232

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： PEUMANS, Peter ,  LAGAE, Liesbet ,  VAN ROY, Willem ,  STAKENBORG, Tim ,  VAN DORPE, Pol

IPC: G01N21/17 ,  G01N21/64

CPC classification number: G01N21/1717 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/1731

Abstract: A sensor device (100) for quantifying luminescent targets comprises a light source (111), a detector (120), a modulator (130), and a processor (140). The light source (111) is adapted for exciting the luminescent target. The detector (120) is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator (130) is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor (140) is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.

Abstract translation: 用于量化发光靶的传感器装置（100）包括光源（111），检测器（120），调制器​​（130）和处理器（140）。 光源（111）适于激发发光靶。 检测器（120）适于检测发光目标的发光，从而产生包含源自发光目标的期望信号和背景信号的测量信号。 调制器（130）适于调制产生与背景信号的调制不同的期望信号的调制的物理参数。 处理器（140）被配置为将物理参数的调制与期望信号的调制和/或背景信号的调制相关联。

公开(公告)号：WO2017001642A1

公开(公告)日：2017-01-05

申请号：PCT/EP2016/065449

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： VAN ROY, Willem ,  STAKENBORG, Tim ,  COVENS, Kris

IPC: G01N33/543

CPC classification number: G01N33/54393 ,  C12Q1/002 ,  C12Q1/6825 ,  G01N33/523

Abstract: A device (1) for sensing an analyte, the device (1) comprises at least a sample inlet (10) for receiving a sample, affinity probes (111) selected to have a preferential binding to the analyte, a transducer (11) sensitive to a characteristic of the analyte and/or a label attached to the analyte, the transducer not being a FET transducer, and a desalting unit (13) for desalting the received sample.

Abstract translation: 一种用于感测分析物的装置（1），所述装置（1）至少包括用于接收样品的样品入口（10），被选择为具有优先结合分析物的亲和探针（111），敏感器（11） 涉及分析物和/或附着于分析物的标签的特性，换能器不是FET换能器，以及用于对接收到的样品进行脱盐的脱盐单元（13）。

公开(公告)号：WO2017001526A1

公开(公告)日：2017-01-05

申请号：PCT/EP2016/065219

申请日：2016-06-29

Applicant: IMEC VZW

Inventor： PEUMANS, Peter ,  LAGAE, Liesbet ,  VAN ROY, Willem ,  STAKENBORG, Tim ,  VAN DORPE, Pol

IPC: G01N21/64 ,  G01N21/17

CPC classification number: G01N21/6452 ,  G01N21/1717 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/1731 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439

Abstract: A sensor device (100) for quantifying luminescent targets configured in an at least one dimensional pattern. The sensor device comprises a detector (120) for obtaining an at least one dimensional pattern of measured signals, wherein the detector (120) is adapted for detecting the luminescence of the luminescent targets, resulting in a measured pattern. The sensor device moreover comprises a processor (140) configured to correlate the measured pattern with at least one reference pattern, so as to generate a measurement signal representative for the quantification of luminescent targets. The at least one reference pattern is a recorded pattern or an expected pattern. A recorded pattern is a pattern which is obtained by the detector before the measured pattern is obtained.

Abstract translation: 一种用于量化以至少一维图案配置的发光目标的传感器装置（100）。 传感器装置包括用于获得测量信号的至少一维图案的检测器（120），其中检测器（120）适于检测发光靶的发光，产生测量图案。 传感器装置还包括被配置成将所测量的图案与至少一个参考图案相关联的处理器（140），以产生代表发光目标的量化的测量信号。 至少一个参考图案是记录图案或预期图案。 记录图案是在获得测量图案之前由检测器获得的图案。

公开(公告)号：WO2017001262A1

公开(公告)日：2017-01-05

申请号：PCT/EP2016/064441

申请日：2016-06-22

Applicant: IMEC VZW

Inventor： PEUMANS, Peter ,  LAGAE, Liesbet ,  VAN ROY, Willem ,  STAKENBORG, Tim ,  VAN DORPE, Pol

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/6456 ,  G01N21/648

Abstract: A sensor device (100) for quantifying luminescent targets. The device comprises a light source (111) for exciting the targets, thus generating luminescence signals, and a detector (120) for detecting these signals of the targets in a cell (310), resulting in a detected signal comprising a desired signal and a background signal. The detector (120) has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor (140) configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.

Abstract translation: 一种用于量化发光靶的传感器装置（100）。 该装置包括用于激发目标的光源（111），从而产生发光信号，以及用于检测单元（310）中的目标的这些信号的检测器（120），从而产生包括期望信号和 背景信号。 检测器（120）具有如此之高的空间单元分辨率和/或时间分辨率，以便在以低浓度测量时只有有限数量的目标将存在于单元格中，和/或仅有限数量的目标添加到 两个测量之间的单元格。 在检测到的信号中可以观察到单元格中的目标数量的变化。 该设备包括被配置为区分期望和背景信号并且将检测到的不同小区和/或时刻的信号组合在一起以量化目标的处理器（140）。