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1.发明公开
公开(公告)号：EP2264191A1
公开(公告)日：2010-12-22
申请号：EP10010565.9
申请日：2004-11-22
发明人： Yin, Ray , Qin, Dujie , Pan, Jing
IPC分类号： C12Q1/68 , C12N9/96 , C07K16/00 , G01N33/53 , G01N33/533 , G01N33/553
CPC分类号： G01N33/5308 , A61K47/6949 , A61K49/0002 , B82Y5/00 , B82Y10/00 , B82Y30/00 , Y10S435/975 , Y10T436/11
摘要： Asymmetrically branched polymers are combined with bioactive agents for a variety of purposes including drug delivery and conjugation to one member of a binding pair for use in an assay.
摘要翻译： 将不对称支化的聚合物与生物活性剂结合用于多种目的，包括药物递送和与用于测定的结合对的一个成员结合。
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公开(公告)号：EP3881828A3
公开(公告)日：2021-10-13
申请号：EP21169376.7
申请日：2014-02-01
发明人： Yin, Ray , Pan, Jing , Zhang, Yubei , Zhou, Bingsen , Yen, Yun
摘要： The present invention is related to an aggregate for use in the treatment of cancer, wherein the aggregate comprises
a) a polyoxazoline comprising at least one terminal group modified with a hydrophobic moiety, wherein said polyoxazoline further comprises a linear portion, a branched portion or both, and said branched portion comprises a symmetrically branched polymer, an asymmetrically branched polymer or a combination thereof; wherein said polyoxazoline comprises a ratio of monomer to initiator is 60:1,
b) a taxane, wherein said polyoxazoline and said taxane has a weight ratio of polymer to taxane of 2:1 to 10:1, and
c) a size from 50 nm to about 100 nm before lyophilization.-
公开(公告)号：EP3881828A2
公开(公告)日：2021-09-22
申请号：EP21169376.7
申请日：2014-02-01
发明人： Yin, Ray , Pan, Jing , Zhang, Yubei , Zhou, Bingsen , Yen, Yun
摘要： The present invention is related to an aggregate for use in the treatment of cancer, wherein the aggregate comprises
a) a polyoxazoline comprising at least one terminal group modified with a hydrophobic moiety, wherein said polyoxazoline further comprises a linear portion, a branched portion or both, and said branched portion comprises a symmetrically branched polymer, an asymmetrically branched polymer or a combination thereof; wherein said polyoxazoline comprises a ratio of monomer to initiator is 60:1,
b) a taxane, wherein said polyoxazoline and said taxane has a weight ratio of polymer to taxane of 2:1 to 10:1, and
c) a size from 50 nm to about 100 nm before lyophilization.-
4.发明公开HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE 审中-公开HYDROPHOBE，MOLEKÜLINDUZIERTEUND VERZWEIGTE POLYMERAGGREGATE UND IHRE VERWENDUNG
公开(公告)号：EP2661281A4
公开(公告)日：2015-04-15
申请号：EP12732008
申请日：2012-01-06
申请人： ANP TECHNOLOGIES INC
发明人： QIN DUJIE , YIN RAY , PAN JING , ZHANG YUBEI
IPC分类号： A61K47/30 , A61K9/19 , A61K9/51 , A61K31/337 , A61K31/4375 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/06 , A61K49/12 , A61K51/06 , C08G83/00
CPC分类号： A61K9/14 , A61K9/19 , A61K9/513 , A61K9/5146 , A61K31/337 , A61K31/4375 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/48384 , A61K47/6803 , A61K49/0004 , A61K49/12 , A61K51/06
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公开(公告)号：EP2452197A2
公开(公告)日：2012-05-16
申请号：EP10797481.8
申请日：2010-05-07
发明人： YIN, Ray , PAN, Jing , VALLEJO, Remo, Jr. , SMALL, Thomas , QIN, Dujie , CHEN, De
IPC分类号： G01N33/538 , G01N33/558 , G01N33/15 , G01N33/02
CPC分类号： G01N33/6854 , G01N33/54306 , G01N33/558
摘要： Assays for detecting antibodies to pharmaceutical preparations, food allergens and environmental allergens are described.
摘要翻译： 描述了用于检测针对药物制剂，食物过敏原和环境过敏原的抗体的测定。
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公开(公告)号：EP3925625A1
公开(公告)日：2021-12-22
申请号：EP21161293.2
申请日：2012-01-06
发明人： Qin, Dujie , Yin, Ray , Pan, Jing , Zhang, Yubei
IPC分类号： A61K47/30 , A61K49/06 , A61K49/04 , A61K47/34 , A61K45/06 , A61K9/19 , A61K49/12 , A61K49/00 , A61K51/06 , A61K9/51 , A61K31/337 , A61K33/24 , C08G83/00 , A61K31/4375 , A61K31/4745 , A61K33/243 , A61K47/59 , A61K47/68 , A61P35/00 , A61P31/00
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.
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7.发明公开
公开(公告)号：EP2661281A2
公开(公告)日：2013-11-13
申请号：EP12732008.3
申请日：2012-01-06
发明人： QIN, Dujie , YIN, Ray , PAN, Jing , ZHANG, Yubei
CPC分类号： A61K9/14 , A61K9/19 , A61K9/513 , A61K9/5146 , A61K31/337 , A61K31/4375 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/48384 , A61K47/6803 , A61K49/0004 , A61K49/12 , A61K51/06
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.
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公开(公告)号：EP2452197A4
公开(公告)日：2013-01-23
申请号：EP10797481
申请日：2010-05-07
申请人： ANP TECHNOLOGIES INC
发明人： YIN RAY , PAN JING , VALLEJO REMO JR , SMALL THOMAS , QIN DUJIE , CHEN DE
IPC分类号： G01N33/538 , G01N33/02 , G01N33/15 , G01N33/558
CPC分类号： G01N33/6854 , G01N33/54306 , G01N33/558
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公开(公告)号：EP1877553A4
公开(公告)日：2009-02-18
申请号：EP06751990
申请日：2006-05-02
申请人： ANP TECHNOLOGIES INC
IPC分类号： G01N33/53 , A61K31/74 , C12M1/00 , C12N11/08 , G01N33/20 , G01N33/42 , G01N33/532 , G01N33/533 , G01N33/543 , G01N33/544 , G01N33/547
CPC分类号： G01N33/545 , B82Y5/00 , B82Y10/00 , G01N33/532 , G01N33/54353 , G01N33/6854
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公开(公告)号：EP1697543A2
公开(公告)日：2006-09-06
申请号：EP04811575.2
申请日：2004-11-22
发明人： YIN, Ray , QIN, Dujie , PAN, Jing
IPC分类号： C12Q1/68 , C12N9/96 , C07K16/00 , G01N33/53 , G01N33/533 , G01N33/553
CPC分类号： G01N33/5308 , A61K47/6949 , A61K49/0002 , B82Y5/00 , B82Y10/00 , B82Y30/00 , Y10S435/975 , Y10T436/11
摘要： Asymmetrically branched polymers are combined with bioactive agents for a variety of purposes including drug delivery and conjugation to one member of a binding pair for use in an assay.
摘要翻译： 不对称支化的聚合物与生物活性剂结合用于各种目的，包括药物递送和结合到结合对的一个成员以用于测定。
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