公开(公告)号：EP3335567A1

公开(公告)日：2018-06-20

申请号：EP16834706.0

申请日：2016-08-05

申请人： FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL 12 DE OCTUBRE ,  Sive Fluid Systems, S.L. ,  Probisearch, S.L.

发明人： ESCUDER VIECO, Diana ,  PALLÁS ALONSO, Carmen Rosa ,  SIEGFRIED SELEY, Pablo ,  FERNÁNDEZ ÁLVAREZ, Leonides ,  RODRÍGUEZ GÓMEZ, Juan Miguel ,  ESPINOSA MARTOS, Irene

IPC分类号： A23C3/03

CPC分类号： A23C3/033 ,  A23C9/206

摘要： The invention relates to a continuous pasteuriser for human milk, which enables pathogenic microorganisms in the milk to be eliminated and the nutritional and immunological quality thereof to be improved. The pasteuriser comprises: an inlet tank (1) and an outlet tank (8) with agitation systems (2, 9) in each tank; a peristaltic pump (4); a heating circuit (5) in which pasteurisation takes place at a temperature between 72 and 75°C for a period of 10 to 20 seconds at a flow rate of 10 l/h; and a cooling circuit (6) integrated with a mechanical system (7) for producing coldness, allowing the milk to be released at a temperature between 2 and 4°C for the subsequent packaging thereof in optimal hygienic and sanitary conditions. All of the components and processes are regulated by means of a control unit (12).

公开(公告)号：EP3865513A1

公开(公告)日：2021-08-18

申请号：EP20382113.7

申请日：2020-02-17

申请人： FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL 12 DE OCTUBRE ,  Fundación Cris de Investigación Para Vencer al Cáncer ,  Hospital Clínic de Barcelona ,  Institut D'Investigaciones Biomèdiques August Pi i Sunyer

发明人： ÁLVAREZ VALLINA, Luis Manuel ,  BLANCO DURANGO, Belén ,  JUAN OTERO, Manel

IPC分类号： C07K16/28 ,  A61P35/02

摘要： The present invention relates to a bispecific antibody comprising an anti-CD19 single-chain fragment variable and an anti-CD3 single-chain fragment variable. The present invention also relates to T cells secreting the bispecific antibody, method of preparation of T cells secreting the bispecific antibody and uses thereof in the treatment of a hematological malignancy selected from the group consisting of lymphoma, leukemia and myeloma.

公开(公告)号：EP4151162A1

公开(公告)日：2023-03-22

申请号：EP21805052.4

申请日：2021-05-10

申请人： FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL 12 DE OCTUBRE

发明人： TAJUELO LLOPIS, Imanol

IPC分类号： A61B17/12

摘要： An anchor system for anchoring an umbilical catheter to an umbilical cord is disclosed. The system comprises a vascular anchor element and an anchor clamp. The vascular anchor element comprises a conduit configured to accommodate a portion of an umbilical catheter, and one end configured to be inserted into a blood vessel of the umbilical cord. The anchor clamp is configured to releasably retain at least one portion of the umbilical cord and at least one portion of the anchor element. The clamp comprises a recess configured to receive the at least one portion of the umbilical cord and the at least one portion of the anchor element; and a releasable closure system for selectively opening/closing the anchor clamp.

公开(公告)号：EP2959935A1

公开(公告)日：2015-12-30

申请号：EP14754438.1

申请日：2014-02-06

申请人： FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL 12 DE OCTUBRE

发明人： VILLALTA GARCIA, Pedro

IPC分类号： A61M39/02

CPC分类号： A61M39/26 ,  A61M39/22 ,  A61M2039/263

摘要： An anti-blood-loss valve based on a valve body (6) of flexible, soft material, divided into two parts by an open/close valve (3) on each side of which two valves are seen, one for extracting blood for analysis (4) and the other for blood for reinfusion (5). The valve body (6) also has an input with a connector to the catheter (1) and, opposite, another connector to the serum and/or reinfusion system (2).

摘要翻译： 一种基于柔性软质材料的阀体（6）的防血阀，通过开/关阀（3）分成两部分，每侧有两个阀，一个用于提取血液用于分析 （4），另一个用于输血的血液（5）。 阀体（6）还具有输入，其具有与导管（1）的连接器，并且与血清和/或再灌注系统（2）相反的另一个连接器相对。

公开(公告)号：EP4169936A1

公开(公告)日：2023-04-26

申请号：EP21382952.6

申请日：2021-10-22

申请人： FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL 12 DE OCTUBRE ,  Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas O.A., M.P. (CIEMAT)

发明人： Valeri Lozano, Antonio ,  Castellano Esparza, Eva ,  García Ortiz, Almudena ,  Maroto Martín, Elena ,  Encinas Mayoral, Jessica ,  Alonso Fernández, Rafael ,  Río Galdo, Paula ,  Martínez López, Joaquín

IPC分类号： C07K14/52 ,  C07K16/28 ,  A01K67/027

摘要： Human immune system transgenic mouse having the genotype Rag2 -/- , II2rg -/- , Sirpa NOD , Flt3 -/- , engrafted with bone marrow mononuclear cells (BMMCs) obtained from a subject having multiple myeloma, administered with antibodies recognizing human gp130, and administered with human FLT3 ligand (hFLT3-L). Method for predicting the anti-tumour response of the subject to a multiple myeloma treatment, comprising evaluating the anti-tumour response of the humanized mouse of the invention to the multiple myeloma treatment.

公开(公告)号：EP2743678A1

公开(公告)日：2014-06-18

申请号：EP12821746.0

申请日：2012-08-07

申请人： Consejo Superior De Investigaciones Científicas (CSIC) ,  Instituto de Salud Carlos III ,  Fundación Cien ,  Fundación Para La Investigación Biomédica Del Hospital 12 de Octubre

发明人： CARMONA HERNÁNDEZ, Pedro ,  TOLEDANO GASCA, Adolfo ,  CALERO LARA, Miguel ,  MARTÍNEZ MARTÍN, Pablo ,  BERMEJO PAREJA, Félix

IPC分类号： G01N21/35

CPC分类号： G01N33/49 ,  G01N21/3577 ,  G01N2800/2821

摘要： The present invention relates to a method for transmission infrared spectroscopic analysis for determining the degree of global cognitive impairment associated with Alzheimer's disease based on analyzing the 3100-1300 cm -1 infrared spectrum region of a previously obtained and fractionated sample of blood. Preferably, the fractionated sample of blood to be analyzed is a fraction of leukocytes.
Likewise, another object of the present invention relates to the use of said method to obtain an indication of the status of the Alzheimer's disease and/or an indication of the degree of cognitive impairment associated with said disease.

摘要翻译： 本发明涉及一种用于为确定性采矿与阿尔茨海默氏病相关的全球认知损害的基础上分析该3100-1300 -1的血液中的以前取得并分级的样品的红外光谱区中的传输程度红外光谱分析的方法。 优选地，待分析的血液中的分级的样品是白细胞的一小部分。 同样地，本发明的另一个目的涉及使用所述方法来获得上的阿耳茨海默氏病和/或与所述疾病有关的认知损害的程度的指示状态指示。