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1.发明公开Method of obtaining cochlear structures, vaccine compositions, adjuvants and intermediates thereof 审中-公开Verfahren zum Erhalt vonKochleärstrukturen，Impfzusammensetzungen，Adjuvanten und Zwischenprodukten davon
公开(公告)号：EP2347764A2
公开(公告)日：2011-07-27
申请号：EP10185705.0
申请日：2003-11-27
发明人： Perez Martin, Oliver Germán , Bracho Grando, Gustavo Rafael , Lastre Gonzalez, Miriam de San Juan Bosco , Sierra Gonzalez, Victoriano Gustavo , Campa Huergo, Concepcion , Mora Gonzalez, Nestor , Barbera Morales, Ramon Faustino , Del Campo Alonso, Judith Monica , Rodriguez Ramirez, Tamara , Zayas Vignier, Caridad , Gil Martinez, Danay , Taboada Suarez, Carlos
IPC分类号： A61K39/095 , A61K39/008 , A61K39/39 , A61K39/00 , A61K39/02
CPC分类号： A61K9/0043 , A61K9/0019 , A61K9/006 , A61K39/008 , A61K39/0275 , A61K39/095 , A61K47/46 , A61K2039/55594 , Y02A50/41 , Y02A50/482
摘要： The present invention has applications in the field of immunology, specifically in the sphere of adjuvants and vaccines. The invention aims at obtaining cochlear structures from vesicles found in the outer membranes of microorganisms, in order to employ them in the preparation of adjuvants and vaccines. The invention also discloses a method for obtaining cochlear structures.
摘要翻译： 本发明在免疫学领域中的应用，特别是在佐剂和疫苗领域中的应用。 本发明旨在从微生物外膜中发现的囊泡获得耳蜗结构，以便将其用于制备佐剂和疫苗。 本发明还公开了一种用于获得耳蜗结构的方法。
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2.发明公开INACTIVATED VIBRIO CHOLERAE VACCINE IN TABLET FORM 审中-公开在TABLETTENFORM中的INAKTIVIERTE VIBRIO-CHOLERAE-VAKZINE
公开(公告)号：EP1614427A1
公开(公告)日：2006-01-11
申请号：EP04721813.6
申请日：2004-03-19
发明人： TALAVERA CORONEL, Arturo , ANO LOPEZ, Gemma , CASTANO FERN NDEZ, Jorge, Luis , URRIBARRI HERN NDEZ, Evangelina , PINO NAVARRO, Yadira , GARCIA SANCHEZ, Hilda, Maria , BALMASEDA PEREZ, Tania , CEDR MARRERO, Bárbara , GARCIA IMIA, Luis , P REZ QUINOY, José, Luis , TORRES SUAREZ, Caridad
IPC分类号： A61K39/106 , A61K9/28
CPC分类号： A61K39/107 , A61K9/20 , A61K2039/521 , A61K2039/522 , A61K2039/542 , Y02A50/472
摘要： The present invention has applications in the field of vaccinology, specifically as an orally administered vaccine for the cholera infection. The aim is to develop a vaccine for oral administration in tablets derived from whole, inactivated cells of Vibrio cholera, and to disclose a method for obtaining this vaccine preparation.
摘要翻译： 本发明在疫苗学领域中的应用，特别是作为霍乱感染的口服疫苗。 目的是开发一种用于口服来源于霍乱弧菌的全部灭活细胞的片剂的疫苗，并公开获得该疫苗制剂的方法。
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公开(公告)号：EP2359850A1
公开(公告)日：2011-08-24
申请号：EP09827196.8
申请日：2009-11-19
发明人： PEREZ MARTIN, Oliver Germán , GONZALEZ AZNAR, Elizabeth , ROMEU ALVAREZ, Belkis , DEL CAMPO ALONSO, Judith Mónica , ACEVEDO GROGUES, Reinaldo , LASTRE GONZALEZ, Miriam de San Juan Bosco , ZAYAS VIGNIER, Caridad , CUELLO PEREZ, Maribel , CABRERA BLANCO, Osmir , NUÑEZ GUTIERREZ, Niurys , BALBOA GONZALEZ, Julio Antonio
IPC分类号： A61K39/095 , A61K9/127 , A61P37/04
CPC分类号： A61K39/095 , A61K39/0017 , A61K39/05 , A61K39/08 , A61K39/099 , A61K2039/542 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , A61K2039/55594 , A61K2039/70
摘要： The invention is related to the field of vaccines. The technical objective is to obtain novel unitemporal therapeutic and prophylactic vaccines (single time vaccination strategy) using simultaneously one or more mucosal doses and one parenteral dose where the use of potent mucosal adjuvants are essential, preferable the Cochleate (AFCo1, Adjuvant Finlay Cochleate 1). The incorporation or co-administration by parenteral and mucosal routes of non-related PL antigens (heterologous), and/or the additional use of delivery systems like Aluminum, Chitosan or oil/water emulsions by parenteral application is also included in this invention. The induction of cellular immune responses than including systemic specific IgG and secretory specific IgA is obtained with at least two simultaneously doses. So, this unitemporal strategy is applicable to obtaining new unique or multiples vaccines (several mucosal vaccine antigens with the corresponding parenteral combine vaccine) in the pharmaceutical industry which permit to increase vaccine coverage and reduce the time-cost of vaccine campaigns.
摘要翻译： 本发明涉及疫苗领域。 技术目标是使用同时一种或多种粘膜剂量和一种肠胃外剂量获得新颖的单时间治疗和预防性疫苗（单次接种疫苗策略），其中使用有效粘膜佐剂是必需的，优选耳蜗（AFCo1，辅助Finlay Cochleate 1） 。 通过胃肠外和粘膜途径引入或共同施用非相关PL抗原（异源），和/或通过肠胃外应用附加使用递送系统如铝，壳聚糖或油/水乳剂也包括在本发明中。 使用至少两个同时剂量获得比包括全身特异性IgG和分泌特异性IgA的细胞免疫应答的诱导。 因此，这种单时间策略适用于在制药行业获得新的独特或多重疫苗（几种具有相应的肠胃外联合疫苗的粘膜疫苗抗原），这可以增加疫苗覆盖面积，并减少疫苗运动的时间成本。
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4.发明授权ALLERGY VACCINE COMPOSITION, PRODUCTION METHOD THEREOF AND USE OF SAME IN ALLERGY TREATMENT 有权过敏症疫苗组合物，工艺用于生产相同的，它们在治疗过敏
公开(公告)号：EP1520587B1
公开(公告)日：2011-06-29
申请号：EP03724819.2
申请日：2003-05-08
申请人： Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros , CENTRO NACIONAL DE BIOPREPARADOS
发明人： Lastre González, Miriam de San Juan , Pérez Martín, Oliver Germán , Labrada Rosado, Alexis , Bidot Martínez, Igor , Pérez Lastre, Jorge Ernesto , Bracho Granada, Gustavo Rafael , Del Campo Alonso, Judith Mónica , Pérez Lastre, Dainerys Aleida , Facenda Ramos, Elisa , Zayas Vignier, Caridad , Rodríguez Martínez, Claudio , Sierra Gonzàlez, Victoriano Gustavo
CPC分类号： A61K39/35 , A61K2039/55505 , A61K2039/55583 , A61K2039/55594 , A61K2039/57 , A61K2039/6018
摘要： The invention relates to the field of immunology, immunoallergy and, in particular, the use of adjuvants or carriers in order to modulate the immunological response to allergens. The technical objective of the invention is: to produce a therapeutic or prophylactic pharmaceutical preparation using bacterial proteoliposomes, which, when applied to allergic individuals, transforms the Th2- and IgE-dependent allergic response into a protective Th1 response; and to prevent the appearance and development of allergies in not-yet allergic individuals. The vaccine composition consists of proteoliposomes of gram-negative bacteria coupled with allergens and, optionally, other antigens or adjuvants. The invention also relates to the method of producing the inventive vaccine composition and to the two-dose schedule for immunisation with said vaccine composition.
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5.发明公开METHOD OF OBTAINING COCHLEAR STRUCTURES, VACCINE COMPOSITIONS, ADJUVANTS AND INTERMEDIATES THEREOF 有权方法计算耳蜗结构，疫苗组合物，工具和其中间体
公开(公告)号：EP1602360A1
公开(公告)日：2005-12-07
申请号：EP03773445.6
申请日：2003-11-27
发明人： PEREZ MARTIN, Oliver Germán , BRACHO GRANDO, Gustavo Rafael , LASTRE GONZALEZ, Miriam de San Juan Bosco , SIERRA GONZALEZ, Victoriano Gustavo , CAMPA HUERGO, Concepcion , MORA GONZALEZ, Nestor , BARBERA MORALES, Ramon, Faustino , DEL CAMPO ALONSO, Judith, Monica , RODRIGUEZ RAMIREZ, Tamara , ZAYAS VIGNIER, Caridad , GIL MARTINEZ, Danay , TABOADA SUAREZ, Carlos
CPC分类号： A61K9/0043 , A61K9/0019 , A61K9/006 , A61K39/008 , A61K39/0275 , A61K39/095 , A61K47/46 , A61K2039/55594 , Y02A50/41 , Y02A50/482
摘要： The present invention has applications in the field of immunology, specifically in the sphere of adjuvants and vaccines. The invention aims at obtaining cochlear structures from vesicles found in the outer membranes of microorganisms, in order to employ them in the preparation of adjuvants and vaccines. The invention also discloses a method for obtaining cochlear structures.
摘要翻译： 本发明具有在免疫学领域中的应用，特别是在佐剂和疫苗的球体。 本发明目的在于获得耳蜗结构中，从微生物的外膜囊泡中发现，为了使用它们的佐剂和疫苗的制备。 因此，本发明盘松动用于获得耳蜗结构的方法。
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6.发明公开
公开(公告)号：EP2548572A2
公开(公告)日：2013-01-23
申请号：EP11777295.4
申请日：2011-05-05
发明人： PÉREZ MARTÍN, Oliver Germán , PÉREZ CUELLO, Maribel , CABRERA BLANCO, Osmir , BALBOA GONZÁLEZ, Julio Antonio , LASTRE GONZÁLEZ, Miriam de San Juan Bosco , ZAYAS VIGNIER, Caridad, Caridad , GONZÁLEZ AZNAR, Elizabeth , ROMEU ALVAREZ, Belkis
IPC分类号： A61K39/015 , A61P33/06
CPC分类号： A61K39/015 , A61K2039/55 , A61K2039/55555 , A61K2039/55594 , A61K2039/57 , Y02A50/412 , Y02A50/484
摘要： The invention relates to the field of vaccinal compositions for the effective or preventive treatment of vertically transmitted infections, especially malaria and preferably human malaria caused by Plasmodium falciparum. The technical aim of the invention is to use the tolerogens transferred, at an early stage, from the mother to the foetus/newborn and to formulate them with potent adjuvants that are inducers of Th1 and cytotoxic T-cell responses in order to use same in prophylactic or therapeutic vaccines against vertically transmitted infections, especially malaria. The use of said formulations at early ages via the parenteral route or via the mucosal route or both at the same time reverts the tolerance induced by the transfer of tolerogens, thereby inducing protective responses.
摘要翻译： 本发明涉及用于有效或预防治疗由恶性疟原虫引起的垂直传播感染，特别是疟疾和优选人类疟疾的疫苗组合物领域。 本发明的技术目的是使用从母体转移到胎儿/新生儿的早期转运的耐受剂，并用作为Th1诱导剂和细胞毒性T细胞应答的有效佐剂来配制它们，以便在 针对垂直传播的感染，特别是疟疾的预防或治疗性疫苗。 通过肠胃外途径或通过粘膜途径或两者同时在早期使用所述制剂来回复由转移耐受性引起的耐受性，从而诱导保护性反应。
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7.发明授权METHOD OF OBTAINING COCHLEAR STRUCTURES, VACCINE COMPOSITIONS, ADJUVANTS AND INTERMEDIATES THEREOF 有权方法计算耳蜗结构，疫苗组合物，工具和其中间体
公开(公告)号：EP1602360B1
公开(公告)日：2011-10-26
申请号：EP03773445.6
申请日：2003-11-27
发明人： PEREZ MARTIN, Oliver Germán , BRACHO GRANDO, Gustavo Rafael , LASTRE GONZALEZ, Miriam de San Juan Bosco , SIERRA GONZALEZ, Victoriano Gustavo , CAMPA HUERGO, Concepción , MORA GONZALEZ, Nestor , BARBERA MORALES, Ramón Faustino , DEL CAMPO ALONSO, Judith Mónica , RODRÍGUEZ RAMÍREZ, Tamara , ZAYAS VIGNIER, Caridad , GIL MARTÍNEZ, Danay , TABOADA SUAREZ, Carlos
CPC分类号： A61K9/0043 , A61K9/0019 , A61K9/006 , A61K39/008 , A61K39/0275 , A61K39/095 , A61K47/46 , A61K2039/55594 , Y02A50/41 , Y02A50/482
摘要： The present invention has applications in the field of immunology, specifically in the sphere of adjuvants and vaccines. The invention aims at obtaining cochlear structures from vesicles found in the outer membranes of microorganisms, in order to employ them in the preparation of adjuvants and vaccines. The invention also discloses a method for obtaining cochlear structures.
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公开(公告)号：EP1582218A1
公开(公告)日：2005-10-05
申请号：EP03778232.3
申请日：2003-11-25
发明人： Acosta Dominguez, Armando , Sarmiento Garcia San Miguel, Maria Elena , Lopez Hernandez, Yamilé , Infante Borzac, Juan Francisco , Cadiz Lahenz, Armando , Falero Rodriguez, Gustavo , Sierra Gonzalez, Victoriano Gustavo , Martinez Benitez, Máximo Berto
CPC分类号： C07K16/1289
摘要： The present invention has applications in the field of immunology - specifically in the control of infectious diseases caused by mycobacteria - based on the use of preparations containing antibodies, administered through mucous membranes and other routes, which have a prophylactic and therapeutic function. Preparations of class IgG, IgA secretory, or mixtures of both human antibodies with specific activity against mycobacterial antigens, have been developed for use in the prevention and treatment of infections brought on by this kind of microorganism. Said preparations proved effective "in vivo" in the inhibition of infections caused by mycobacteria.
摘要翻译： 本发明在免疫学领域具有应用 - 特别是在控制由分枝杆菌引起的感染性疾病 - 基于使用含有抗体的制剂，通过具有预防和治疗功能的粘膜和其他途径施用。 已经开发了用于预防和治疗由这种微生物引起的感染的IgG类，IgA分泌物或两种具有抗分枝杆菌抗原特异活性的人抗体混合物的制剂。 所述制剂在抑制由分枝杆菌引起的感染中被证明是有效的“体内”。
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9.发明公开METHOD OF OBTAINING CONJUGATE VACCINES AND VACCINE COMPOSITIONS CONTAINING SAME 审中-公开方法计算共轭和疫苗组合与SAME
公开(公告)号：EP1582217A1
公开(公告)日：2005-10-05
申请号：EP03773443.1
申请日：2003-11-14
发明人： CABRERA BLANCO, Osmir , CUELLO PEREZ, Maribel , SIERRA GONZALEZ, Victoriano Gustavo , SOTO RODRIGUEZ, Carmen Rosa , MARTINEZ POZO, Miguel Ernesto
CPC分类号： A61K39/095 , A61K39/102 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , Y02A50/484
摘要： This invention is related to biotechnology, specially with the methods of chemical conjugation of antigenic molecules. Hereby enclosed there is a description of a method for the conjugation of saccharides antigens. The invention is based on the generation of amino groups in a saccharide structure, from which one saccharide with two different functional groups is obtained. This method could be used to fix proteins to saccharides. Also included are the conjugates which happen to be effective against bacterial diseases, which were also obtained through the aforementioned method.
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10.发明公开Method of obtaining cochlear structures, vaccine compositions, adjuvants and intermediates thereof 审中-公开一种用于获得Kochleärstrukturen，疫苗组合物，佐剂和其中间体的方法
公开(公告)号：EP2347764A3
公开(公告)日：2011-10-26
申请号：EP10185705.0
申请日：2003-11-27
发明人： Perez Martin, Oliver Germán , Bracho Grando, Gustavo Rafael , Lastre Gonzalez, Miriam de San Juan Bosco , Sierra Gonzalez, Victoriano Gustavo , Campa Huergo, Concepcion , Mora Gonzalez, Nestor , Barbera Morales, Ramon Faustino , Del Campo Alonso, Judith Monica , Rodriguez Ramirez, Tamara , Zayas Vignier, Caridad , Gil Martinez, Danay , Taboada Suarez, Carlos
IPC分类号： A61K39/095 , A61K39/008 , A61K39/39 , A61K39/00 , A61K39/02
CPC分类号： A61K9/0043 , A61K9/0019 , A61K9/006 , A61K39/008 , A61K39/0275 , A61K39/095 , A61K47/46 , A61K2039/55594 , Y02A50/41 , Y02A50/482
摘要： The present invention has applications in the field of immunology, specifically in the sphere of adjuvants and vaccines. The invention aims at obtaining cochlear structures from vesicles found in the outer membranes of microorganisms, in order to employ them in the preparation of adjuvants and vaccines. The invention also discloses a method for obtaining cochlear structures.
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