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1.发明公开
公开(公告)号：EP3677566A1
公开(公告)日：2020-07-08
申请号：EP18890918.8
申请日：2018-11-30
申请人： Zhejiang NHU Company Ltd. , Zhejiang University , Shandong Nhu Amino Acid Co., Ltd. , Shandong Nhu Fine Chemical Science and Technology Company Ltd.
发明人： CHEN, Zhirong , MAO, Jianyong , HU, Baishan , LI, Guanbing , LI, Haoran , WANG, Yu , YANG, Yingkuo , LIU, Qing , TANG, Jiyu , CHEN, Weiyong
IPC分类号： C07C209/52 , C07C209/48 , C07C211/36 , B01J8/02
摘要： The present disclosure relates to a method for preparing isophorone diamine by means of a hydrogenation reduction of isophorone nitrile imine. The hydrogenation reduction is continuously carried out in a multi-stage bubble column reactor loaded with a supported alkaline cobalt-based catalyst, wherein isophorone nitrile imine is successively in countercurrent contact with hydrogen in each stage of the reactor to carry out a hydrogenation reduction reaction, so as to obtain the isophorone diamine. The preparation method solves the problem of back-mixing, and further improves the conversion rate and the cis/trans ratio of the product.
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2.发明公开METAL COMPLEX CATALYST, PREPARATION METHOD THEREOF, AND USE THEREOF IN PREPARING D,L-MENTHOL 审中-公开金属络合物催化剂，其制备方法及其在制备D-，L-薄荷醇中的用途
公开(公告)号：EP3299088A1
公开(公告)日：2018-03-28
申请号：EP16795815.6
申请日：2016-05-10
发明人： YU, Ming , YUAN, Jintao , YU, Haidong , SHAO, Weikang , ZHANG, Yuhong
IPC分类号： B01J23/847 , C07C35/12 , C07C29/20 , C07C29/56 , C22C19/03 , B01J23/835
摘要： The present invention discloses a metal complex catalyst, its preparing method and its application in preparing D,L-menthol, the metal complex catalyst includes weight percent elements as follows: 70-85% of Ni, 8-10% of Al, 5-10% of V, and 2-10% of Co. When this metal complex catalyst is applied in preparing D,L-menthol through thymol hydrogenation, it has the characteristics of high reaction activity and quick racemization of chiral compound. Meanwhile, a certain kind of alkali added in isomerization is the key to reducing light constituent byproduct. The whole process comes in good reaction selectivity, simple preparing technology, low production cost, and environment-friendly synthetic route.
摘要翻译： 本发明公开了一种金属配合物催化剂，其制备方法及其在制备D，L-薄荷醇中的应用，该金属配合物催化剂包括如下重量百分比的元素：70-85％的Ni，8-10％的Al， ，V为10％，Co为2-10％。将该金属配合物催化剂应用于通过麝香草酚氢化制备D，L-薄荷醇时，具有反应活性高，手性化合物外消旋化快的特点。 同时，异构化中加入某种碱是减少轻组分副产物的关键。 整个过程具有反应选择性好，制备工艺简单，生产成本低，环保的合成路线。
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公开(公告)号：EP3020396B1
公开(公告)日：2017-08-09
申请号：EP14823839.7
申请日：2014-06-03
发明人： QIU, Dan , SHI, Lifang , LI, Jiandong , CHEN, Zhirong , ZHOU, Jiachao
IPC分类号： A61K31/015 , A61K9/107 , A61K9/50 , A23L33/105 , A23L5/44
CPC分类号： A23L5/44 , A23L33/105 , A23V2002/00
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公开(公告)号：EP4282856A1
公开(公告)日：2023-11-29
申请号：EP22899903.3
申请日：2022-07-07
申请人： Zhejiang Nhu Pharmaceutical Co. Ltd. , Shangyu Nhu Bio-Chem Co., Ltd. , Zhejiang NHU Company Ltd.
发明人： XU, Songhua , YAO, Xianghua , SONG, Yinjiang , HE, Xiaoxiang , CHEN, Lihuan , LI, Feng , PAN, Yinxia , ZHAN, Pingping
IPC分类号： C07C303/30 , C07C309/14 , B01J31/18
摘要： The present disclosure discloses a method for preparing taurine. The method includes: (1) subjecting a sodium hydroxyethyl sulfonate aqueous solution to an ammonolysis reaction with ammonia under the action of an ammonia water complex ion catalyst to obtain a reaction solution containing sodium taurine; and (2) subjecting the reaction solution containing sodium taurine to deamination, dewatering by concentration, acidification and crystallization to obtain the taurine and a mother solution; where the ammonia water complex ion catalyst is obtained by complexation of ammonia and a catalyst precursor, and the catalyst precursor includes one or more metallic elements of chromium, zinc, nickel, cobalt, copper and silver. The method has the advantages of mild process conditions, short reaction time, high yield and a simple catalyst source.
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公开(公告)号：EP4190769A1
公开(公告)日：2023-06-07
申请号：EP22750655.7
申请日：2022-06-21
申请人： Zhejiang University , Zhejiang NHU Company Ltd. , Zhejiang NHU Special Materials Co., Ltd. , ZHEJIANG NHU NYLON MATERIALS CO., LTD.
发明人： CHEN, Zhirong , WU, Wenbin , YIN, Hong , ZHA, Zengshi , WANG, Keyan , MA, Li , HUANG, Guodong , ZHOU, Guiyang , XU, Yong
IPC分类号： C07C255/04 , C07C253/10 , B01J31/24 , C07F9/6571
摘要： The present disclosure relates to a use of a multidentate phosphite ligand in the catalytic synthesis of adiponitrile. The ligand is represented by the following general formula (I). The method of catalytic synthesis of adiponitrile comprises primary hydrocyanation, isomerization, and secondary hydrocyanation reactions, wherein the catalyst adopted each comprises a phosphite ligand-nickel complex composed of a nickel precursor and a multidentate phosphite ligand. The ligand molecule has a higher electron cloud density, and the phosphorus content capable of participating in coordination in the ligand molecule per unit mass is higher, so that the catalytic activity of the catalyst is improved, and the amount of the catalyst is reduced. Meanwhile, the steric and spatial configuration of the phosphite ligand-nickel complex may be adjusted by designing and optimizing the framework structure of the ligand, and the chemical environment and the steric effect around a metal center may be changed by the designing and optimizing mentioned above combine with flexibly regulating the electronic effect and the steric hindrance effect of a substituent on the molecular structure of the ligand, so that the selectivity of a linear product adiponitrile is improved.
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公开(公告)号：EP3456728A1
公开(公告)日：2019-03-20
申请号：EP17870452.4
申请日：2017-05-18
发明人： DENG, Fuxiang , DING, Yu , XUE, Wei , SHENG, Yu , YAN, Wenwu , YU, Ming , ZHOU, Yougui , LI, Haoran
摘要： The present invention discloses a method for preparing sucralose-6-acetate in a biphasic liquid-liquid system. The method comprises slowly dropwise adding an inert non-polar solvent containing a chlorinating agent to an N,N-dimethyl formamide (DMF) solution of sucrose-6-acetate; then reacting the biphasic liquid-liquid mixture at a certain temperature for 9-20 hours; cooling the system to room temperature after stopping heating, and settling the solution to form layers, an upper layer being an inert non-polar solvent layer, and a lower layer being a DMF solution layer containing the product; hydrolyzing, neutralizing, and filtering the lower layer to obtain a filtrate, and then concentrating the filtrate to obtain a concentrate; dissolving the concentrate in water, and obtaining the product by extraction using ethyl acetate and crystallization, the inert non-polar solvent being an alkane solvent containing 8-18 carbon atoms that is not mutually soluble with DMF. The method has a high product yield, and can significantly reduce the decomposition of DMF, thereby reducing costs.
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7.发明公开
公开(公告)号：EP3725821A1
公开(公告)日：2020-10-21
申请号：EP19863994.0
申请日：2019-08-23
IPC分类号： C08G75/0209 , C08G75/0227 , C08G75/0259
摘要： The disclosure relates to a high molecular weight polyphenylene sulfide resin and a preparation method and application thereof. The disclosure uses a sulfur-containing compound and a halogenated aromatic compound as raw materials, an alkaline compound and a fatty acid as polycondensation aids to carry out a polycondensation reaction. After purification treatment, aprimarypolyphenylene sulfide is obtained. Then, the primary polyphenylene sulfide reacts with a chain extender at a high temperature to form a high molecular weight polyphenylene sulfide resin.The preparation method of the disclosure has the advantages of high yield, low cost, and is capable of selectively and controllably preparing polyphenylene sulfide resins with different melt viscosities and molecular weights, and the obtained polyphenylene sulfide resins have excellent heat resistance.The linear high molecular weight polyphenylene sulfide resin with high thermal stability obtained by the disclosure can be used for producing plates, pipes and rods, can be mechanically processed like metals, such as cutting, grinding, polishing, drilling,and can be used to produce fibers, membranes, films, and especially are applicable toautomotive parts, electronic/electrical equipment, chemical and machinery industry.
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8.发明公开
公开(公告)号：EP3677617A1
公开(公告)日：2020-07-08
申请号：EP18894563.8
申请日：2018-07-12
发明人： LI, Woyuan , YIN, Hong , CHEN, Zhirong , HU, Baishan , ZHOU, Guiyang , DENG, Hangjun , LIAN, Ming , ZHANG, Xiongwei , LI, Qichuan , ZHAO, Jiang
IPC分类号： C08G75/029 , C08G75/0254 , C08L81/02
摘要： The disclosure relates to a preparation method of a polyphenylene sulfide resin, and a polyphenylene sulfide resin prepared by the method. The disclosure uses a sulfur-containing compound, an alkaline substance and p-dichlorobenzene as raw materials, a fatty acid as a polycondensation aid to carry out a polycondensation reaction. After purification treatment, a primary polyphenylene sulfide is obtained, which then reacts with a terminal-group adjusting agent at a high temperature to generate the polyphenylene sulfide resin. The preparation method of the disclosure has high yield and low cost, and the prepared polyphenylene sulfide resin has high reactivity, high melting crystallization temperature and excellent thermal stability. The polyphenylene sulfide resin of the disclosure can be directly used for extrusion and injection molding, and is especially applicable to fields such as automobile parts, electronic / electrical equipment, chemical industry, and machinery industry.
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9.发明授权
公开(公告)号：EP3299088B1
公开(公告)日：2020-01-08
申请号：EP16795815.6
申请日：2016-05-10
发明人： YU, Ming , YUAN, Jintao , YU, Haidong , SHAO, Weikang , ZHANG, Yuhong
IPC分类号： B01J23/847 , C07C35/12 , C07C29/20 , C07C29/56 , C22C19/03 , B01J23/835 , B01J37/06 , B01J25/02
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10.发明公开
公开(公告)号：EP3339452A1
公开(公告)日：2018-06-27
申请号：EP16858964.6
申请日：2016-10-21
发明人： YU, Hongwei , LV, Yong , LI, Yong , CHEN, Jianbo , CHEN, Shaofeng , LI, Weifeng , ZHANG, Hongmei , ZHU, Yongqiang
摘要： The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.
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