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    METHOD OF PRODUCING L-AMINO ACID
    2.
    发明公开
    METHOD OF PRODUCING L-AMINO ACID 审中-公开
    生产L-氨基酸的方法

    公开(公告)号：EP2113570A1

    公开(公告)日：2009-11-04

    申请号：EP08711794.1

    申请日：2008-02-22

    申请人： Ajinomoto Co., Inc.

    发明人： NAGAI, Yuri ,  HAYASHI, Kazuyuki ,  UEDA, Takuji ,  USUDA, Yoshihiro ,  MATSUI, Kazuhiko

    IPC分类号： C12P13/04 ,  C12N15/09 ,  C12N1/21

    CPC分类号： C12P13/08 ,  C12P13/04

    摘要： An L-amino acid is produced by culturing a microorganism belonging to the family Enterobacteriaceae , having an L-amino acid-producing ability and modified to increase glycerol dehydrogenase and dihydroxyacetone kinase activities, in a medium containing glycerol as a carbon source to produce and accumulate an L-amino acid in the medium or cells, and collecting the L-amino acid from the medium or the cells.

    摘要翻译： 通过培养属于肠杆菌科的具有L-氨基酸生产能力并经过修饰以增加甘油脱氢酶和二羟基丙酮激酶活性的微生物在含有甘油作为碳源的培养基中生产L-氨基酸以产生和积累 培养基或细胞中的L-氨基酸，并从培养基或细胞中收集L-氨基酸。

    MANUFACTURING METHOD FOR MUTANT rpsA GENE AND L-AMINO ACID
    5.
    发明公开
    MANUFACTURING METHOD FOR MUTANT rpsA GENE AND L-AMINO ACID 审中-公开
    HERSTELLUNGSVERFAHRENFÜRMUTANTE RPSA-GENE UND L-AMINOSÄURE

    公开(公告)号：EP2535407A1

    公开(公告)日：2012-12-19

    申请号：EP11739901.4

    申请日：2011-02-07

    申请人： Ajinomoto Co., Inc.

    发明人： DOI, Hidetaka ,  HAGIWARA, Yusuke ,  USUDA, Yoshihiro

    IPC分类号： C12N15/09 ,  C12N1/20 ,  C12P13/04 ,  C12R1/19

    CPC分类号： C12P13/04 ,  C07K14/24 ,  C07K14/245 ,  C12P13/08

    摘要： A method for efficiently producing an L-amino acid utilizing a bacterium belonging to the family Enterobacteriaceae from a fatty acid or an alcohol such as glycerol as a raw material is provided. A bacterium belonging to the family Enterobacteriaceae, having an L-amino acid-producing ability, and harboring a mutant RpsA protein having a mutation that the aspartic acid residue at position 210 is replaced with another amino acid residue is cultured in a medium containing a carbon source selected from a fatty acid and an alcohol, and an L-amino acid is collected from the medium thereby to produce the L-amino acid.

    摘要翻译： 提供了利用脂肪酸或醇如甘油作为原料的属于肠杆菌科的细菌的L-氨基酸有效生产的方法。 属于肠杆菌科的细菌，具有L-氨基酸生产能力，并且携带具有突变的突变型RpsA蛋白质，其中位置210处的天冬氨酸残基被另一个氨基酸残基替代，在含有碳的培养基中培养 选自脂肪酸和醇的源，并从培养基中收集L-氨基酸，从而产生L-氨基酸。

    PROCESS FOR PRODUCTION OF L-AMINO ACID
    6.
    发明公开
    PROCESS FOR PRODUCTION OF L-AMINO ACID 有权
    生产L-氨基酸的方法

    公开(公告)号：EP2471942A1

    公开(公告)日：2012-07-04

    申请号：EP10811606.2

    申请日：2010-07-01

    申请人： Ajinomoto Co., Inc.

    发明人： DOI, Hidetaka ,  USUDA, Yoshihiro

    IPC分类号： C12P13/04 ,  C12N1/21 ,  C12N9/10 ,  C12N15/09

    CPC分类号： C12P13/08 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/78 ,  C12N9/80 ,  C12P13/12 ,  C12P13/227 ,  C12Y203/01109 ,  C12Y206/01081 ,  C12Y305/01096 ,  C12Y305/03023

    摘要： A method for producing an L-amino acid which comprisese culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid producing ability in a medium to produce and accumulate an L-amino acid in the medium and collecting the L-amino acid from the medium, wherein the bacterium has been modified so that activity or activities of one or two or more kinds of enzymes of the arginine succinyltransferase pathway, such as arginine succinyltransferase, succinylarginine dihydrolase, succinylornithine aminotransferase, succinylglutamate-semialdehyde dehydrogenase and succinylglutamate desuccinylase, is/are decreased.

    摘要翻译： 一种生产L-氨基酸的方法，包括在培养基中培养属于肠杆菌科并具有L-氨基酸生产能力的细菌以在培养基中生产和积累L-氨基酸并收集L-氨基酸 其中所述细菌已经被修饰以便精氨酸琥珀酰转移酶途径的一种或两种或更多种酶如精氨酸琥珀酰转移酶，琥珀酰精氨酸二氢酶，琥珀酰鸟氨酸转氨酶，琥珀酰谷氨酸半醛脱氢酶和琥珀酰谷氨酸脱琥珀酰化酶的活性或活性是 /减少。

    BACTERIUM CAPABLE OF PRODUCING L-AMINO ACID, AND METHOD FOR PRODUCING L-AMINO ACID
    7.
    发明公开
    BACTERIUM CAPABLE OF PRODUCING L-AMINO ACID, AND METHOD FOR PRODUCING L-AMINO ACID 有权
    VERFAHREN ZUR PRODUKTION VON L-AMINOSÄURE

    公开(公告)号：EP2343371A1

    公开(公告)日：2011-07-13

    申请号：EP09811547.0

    申请日：2009-09-03

    申请人： Ajinomoto Co., Inc.

    发明人： NISHIO, Yousuke ,  USUDA, Yoshihiro

    IPC分类号： C12N15/09 ,  C12N1/21 ,  C12P13/10 ,  C12P13/14 ,  C07K14/195

    CPC分类号： C12P13/08 ,  C12P13/10 ,  C12P13/14

    摘要： A bacterium which belongs to the Enterobacteriaceae family, has an ability to produce an L-amino acid selected from L-glutamic acid, L-arginine and L-threonine, and is modified so that the activity of a protein encoded by ydcl gene is decreased is cultuerd in a culture medium, thereby producing and accumulating the L-amino acid selected from L-glutamic acid, L-arginine and L-threonine in the culture medium or cells of the bacterium. Subsequently, the L-amino acid is collected from the culture medium or the cells.

    摘要翻译： 属于肠杆菌科的细菌具有产生选自L-谷氨酸，L-精氨酸和L-苏氨酸的L-氨基酸的能力，并被修饰，使得由ydcl基因编码的蛋白质的活性降低 在培养基中培养，从而在细菌的培养基或细胞中产生并积累选自L-谷氨酸，L-精氨酸和L-苏氨酸的L-氨基酸。 随后，从培养基或细胞收集L-氨基酸。

    METHOD FOR PRODUCTION OF ORGANIC ACID
    8.
    发明公开
    METHOD FOR PRODUCTION OF ORGANIC ACID 审中-公开
    生产有机酸的方法

    公开(公告)号：EP2149608A1

    公开(公告)日：2010-02-03

    申请号：EP08740478.6

    申请日：2008-04-16

    申请人： Ajinomoto Co., Inc.

    发明人： FUKUI, Keita ,  TAJIMA, Yoshinori ,  KAWAMURA, Kazue ,  USUDA, Yoshihiro ,  MATSUI, Kazuhiko

    IPC分类号： C12P7/46 ,  C12N15/09 ,  C12R1/01 ,  C12R1/185 ,  C12R1/22

    CPC分类号： C12P7/46

    摘要： An organic acid is produced by allowing a bacterium which has an ability to produce an organic acid and has been modified so that expression of yidE gene is enhanced or a product obtained by processing the bacterium to act on an organic raw material in a reaction mixture containing carbonate ions, bicarbonate ions, or carbon dioxide gas to produce the organic acid, and collecting the organic acid.

    摘要翻译： 有机酸是通过使具有生产有机酸能力的细菌进行修饰从而增强yidE基因的表达，或者通过加工细菌作用于有机原料而获得的产物在含有 碳酸根离子，碳酸氢根离子或二氧化碳气体以产生有机酸，并收集有机酸。