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12 条记录 (耗时 0.017 秒)

    MANUFACTURING METHOD FOR MUTANT rpsA GENE AND L-AMINO ACID
    4.
    发明公开
    MANUFACTURING METHOD FOR MUTANT rpsA GENE AND L-AMINO ACID 审中-公开
    HERSTELLUNGSVERFAHRENFÜRMUTANTE RPSA-GENE UND L-AMINOSÄURE

    公开(公告)号：EP2535407A1

    公开(公告)日：2012-12-19

    申请号：EP11739901.4

    申请日：2011-02-07

    申请人： Ajinomoto Co., Inc.

    发明人： DOI, Hidetaka ,  HAGIWARA, Yusuke ,  USUDA, Yoshihiro

    IPC分类号： C12N15/09 ,  C12N1/20 ,  C12P13/04 ,  C12R1/19

    CPC分类号： C12P13/04 ,  C07K14/24 ,  C07K14/245 ,  C12P13/08

    摘要： A method for efficiently producing an L-amino acid utilizing a bacterium belonging to the family Enterobacteriaceae from a fatty acid or an alcohol such as glycerol as a raw material is provided. A bacterium belonging to the family Enterobacteriaceae, having an L-amino acid-producing ability, and harboring a mutant RpsA protein having a mutation that the aspartic acid residue at position 210 is replaced with another amino acid residue is cultured in a medium containing a carbon source selected from a fatty acid and an alcohol, and an L-amino acid is collected from the medium thereby to produce the L-amino acid.

    摘要翻译： 提供了利用脂肪酸或醇如甘油作为原料的属于肠杆菌科的细菌的L-氨基酸有效生产的方法。 属于肠杆菌科的细菌，具有L-氨基酸生产能力，并且携带具有突变的突变型RpsA蛋白质，其中位置210处的天冬氨酸残基被另一个氨基酸残基替代，在含有碳的培养基中培养 选自脂肪酸和醇的源，并从培养基中收集L-氨基酸，从而产生L-氨基酸。

    PROCESS FOR PRODUCTION OF L-AMINO ACID
    5.
    发明公开
    PROCESS FOR PRODUCTION OF L-AMINO ACID 有权
    生产L-氨基酸的方法

    公开(公告)号：EP2471942A1

    公开(公告)日：2012-07-04

    申请号：EP10811606.2

    申请日：2010-07-01

    申请人： Ajinomoto Co., Inc.

    发明人： DOI, Hidetaka ,  USUDA, Yoshihiro

    IPC分类号： C12P13/04 ,  C12N1/21 ,  C12N9/10 ,  C12N15/09

    CPC分类号： C12P13/08 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/78 ,  C12N9/80 ,  C12P13/12 ,  C12P13/227 ,  C12Y203/01109 ,  C12Y206/01081 ,  C12Y305/01096 ,  C12Y305/03023

    摘要： A method for producing an L-amino acid which comprisese culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid producing ability in a medium to produce and accumulate an L-amino acid in the medium and collecting the L-amino acid from the medium, wherein the bacterium has been modified so that activity or activities of one or two or more kinds of enzymes of the arginine succinyltransferase pathway, such as arginine succinyltransferase, succinylarginine dihydrolase, succinylornithine aminotransferase, succinylglutamate-semialdehyde dehydrogenase and succinylglutamate desuccinylase, is/are decreased.

    摘要翻译： 一种生产L-氨基酸的方法，包括在培养基中培养属于肠杆菌科并具有L-氨基酸生产能力的细菌以在培养基中生产和积累L-氨基酸并收集L-氨基酸 其中所述细菌已经被修饰以便精氨酸琥珀酰转移酶途径的一种或两种或更多种酶如精氨酸琥珀酰转移酶，琥珀酰精氨酸二氢酶，琥珀酰鸟氨酸转氨酶，琥珀酰谷氨酸半醛脱氢酶和琥珀酰谷氨酸脱琥珀酰化酶的活性或活性是 /减少。

    METHOD FOR PRODUCING L-AMINO ACID
    7.
    发明公开
    METHOD FOR PRODUCING L-AMINO ACID 审中-公开
    生产L-氨基酸的方法

    公开(公告)号：EP2650376A1

    公开(公告)日：2013-10-16

    申请号：EP11846714.1

    申请日：2011-12-08

    申请人： Ajinomoto Co., Inc.

    发明人： DOI, Hidetaka ,  HOSHINO, Yasushi ,  MASUMITSU, Yuri ,  USUDA, Yoshihiro

    IPC分类号： C12P13/08 ,  C12N15/09

    摘要： In a method for producing an L-amino acid comprising culturing a bacterium which belongs to the family Enterobacteriaceae and has an L-amino acid-producing ability in a medium containing a carbon source selected from a fatty acid and an alcohol, and collecting the L-amino acid from the medium, a bacterium which has been subjected to a modification selected from the group consisting of enhancement of oxyS gene expression, enhancement of fixABC gene expression, and combination thereof is used as the bacterium, or a substance that reduces intracellular hydrogen peroxide concentration of the bacterium is added to the medium.

    摘要翻译： 在生产L-氨基酸的方法中，包括在含有选自脂肪酸和醇的碳源的培养基中培养属于肠杆菌科并具有L-氨基酸生产能力的细菌，并收集L 来自培养基的氨基酸，将经过选自氧化
    酶基因表达的增强，修饰的ABC基因表达的增强以及它们的组合的修饰
    的细菌用作细菌，或者使细胞内氢减少的物质 将细菌的过氧化物浓度添加到培养基中。

    METHOD FOR PRODUCTION OF L-LYSINE
    8.
    发明公开
    METHOD FOR PRODUCTION OF L-LYSINE 有权
    VERFAHREN ZUR HERSTELLUNG VON L-LYSIN

    公开(公告)号：EP2180052A1

    公开(公告)日：2010-04-28

    申请号：EP08791407.3

    申请日：2008-07-22

    申请人： Ajinomoto Co., Inc.

    发明人： DOI, Hidetaka ,  UEDA, Takuji

    IPC分类号： C12N15/09 ,  C12N1/21 ,  C12P13/08

    CPC分类号： C12P13/08 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/90

    摘要： L-Lysine is produced by culturing an Escherichia coli having an L-lysine-producing ability, which has been modified to decrease activity or activities of one or more enzymes of the meso-α,ε-diaminopimelic acid synthesis pathway, for example, 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, succinyldiaminopimelate transaminase, succinyldiaminopimelate desuccinylase, and diaminopimelate epimerase, and into which a gene coding for diaminopimelate dehydrogenase has been introduced, in a medium, and collecting L-lysine from the medium.

    摘要翻译： 通过培养具有L-赖氨酸生产能力的大肠杆菌来生产L-赖氨酸，其已被修饰以降低中间体，μ-二氨基庚二酸合成途径的一种或多种酶的活性或活性，例如2 3,4,5-四氢吡啶-2,6-二甲酸N-琥珀酰基转移酶，琥珀酰二氨基庚二酸转氨酶，琥珀酰二氨基庚二酸二琥珀酰基酶和二氨基庚二酸差向异构酶，并在其中引入了编码二氨基庚二酸脱氢酶的基因，并在培养基中收集L-赖氨酸 从媒介

    METHOD FOR PRODUCING L-AMINO ACIDS
    10.
    发明公开
    METHOD FOR PRODUCING L-AMINO ACIDS 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON L-AMINOSÄUREN

    公开(公告)号：EP3153586A1

    公开(公告)日：2017-04-12

    申请号：EP15803550.1

    申请日：2015-06-03

    申请人： Ajinomoto Co., Inc.

    发明人： DOI, Hidetaka ,  MATSUDAIRA, Akiko ,  USUDA, Yoshihiro

    IPC分类号： C12P13/08 ,  C12N15/00 ,  C12N15/09

    CPC分类号： C12P13/08 ,  C12N15/00 ,  C12N15/09

    摘要： A method for producing an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, which has been modified so that the activity of aconitase is increased, or the activities of aconitase and acetaldehyde dehydrogenase are increased, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.

    摘要翻译： 提供了L-氨基酸的制造方法。 通过培养属于肠杆菌科的具有L-氨基酸生产能力的细菌产生L-氨基酸，其已被修饰以使乌头酸酶的活性增加，或者乌头酸酶和乙醛脱氢酶的活性增加 在培养基中，并从细菌的培养基或细胞中收集L-氨基酸。