公开(公告)号：EP2633037B1

公开(公告)日：2017-06-28

申请号：EP11772990.5

申请日：2011-10-24

申请人： Evonik Degussa GmbH

发明人： DISCHERT, Wanda ,  VASSEUR, Perrine ,  BOISART, Cédric ,  FIGGE, Rainer

IPC分类号： C12N9/02 ,  C12N15/52 ,  C12P13/12 ,  C12R1/15 ,  C12R1/19 ,  C12R1/22

CPC分类号： C12P13/12 ,  C12N9/0036 ,  C12N15/52

公开(公告)号：EP2149608A1

公开(公告)日：2010-02-03

申请号：EP08740478.6

申请日：2008-04-16

申请人： Ajinomoto Co., Inc.

发明人： FUKUI, Keita ,  TAJIMA, Yoshinori ,  KAWAMURA, Kazue ,  USUDA, Yoshihiro ,  MATSUI, Kazuhiko

IPC分类号： C12P7/46 ,  C12N15/09 ,  C12R1/01 ,  C12R1/185 ,  C12R1/22

CPC分类号： C12P7/46

摘要： An organic acid is produced by allowing a bacterium which has an ability to produce an organic acid and has been modified so that expression of yidE gene is enhanced or a product obtained by processing the bacterium to act on an organic raw material in a reaction mixture containing carbonate ions, bicarbonate ions, or carbon dioxide gas to produce the organic acid, and collecting the organic acid.

摘要翻译： 有机酸是通过使具有生产有机酸能力的细菌进行修饰从而增强yidE基因的表达，或者通过加工细菌作用于有机原料而获得的产物在含有 碳酸根离子，碳酸氢根离子或二氧化碳气体以产生有机酸，并收集有机酸。

公开(公告)号：EP1300471B1

公开(公告)日：2007-09-12

申请号：EP01947123.4

申请日：2001-06-29

申请人： CENTRO NACIONAL DE BIOPREPARADOS

发明人： TSORAEVA, Anna ,  RODRIGUEZ MARTINEZ, Claudio ,  QUESADA MUNIZ, Vivian de Jesus

IPC分类号： C12Q1/04 ,  C12R1/05 ,  C12R1/19 ,  C12R1/22 ,  C12R1/37 ,  C12R1/385 ,  C12R1/42

CPC分类号： C12Q1/045 ,  Y02A50/59

摘要： The present invention is related with Microbiology and particularly with a nutrient mixture and a procedure for the identification and the early count of Gram-negative organisms. This mixture allows the development of five different colony colors in the organisms to be detected, and the appearance of three colored fluorescent emissions, the appearance of three different colors halos and zones with opaque precipitates surrounding such colonies. Those factors, together with the color changes in the medium, allow a differentiation with a high sensibility and specificity level. The mixture include specific relations of the mixtures of tryptophan rich protein fractions, free tryptophan, organic or inorganic salts, color or fluorescence providing substances, cellulose and hemi cellulose and other components which provide from 1 to 2 layers in the composition.

公开(公告)号：EP0686698B1

公开(公告)日：2001-03-14

申请号：EP95108740.2

申请日：1995-06-07

申请人： LONZA AG

发明人： Kiener, Andreas, Dr. Chem. ,  Roduit, Jean-Paul, Dr. Chem. ,  Kohr, Jörg, Dr. Chem. ,  Shaw, Nicholas, Dr. Biochem.

IPC分类号： C12P17/00 ,  C12P17/10 ,  C12P17/12 ,  C12R1/22 ,  C12R1/38 ,  C12R1/39 ,  C12R1/40

CPC分类号： C12R1/22 ,  C12P17/10 ,  C12P17/12 ,  C12P41/006 ,  C12R1/39 ,  C12R1/40 ,  Y10S435/852 ,  Y10S435/874 ,  Y10S435/876 ,  Y10S435/877 ,  Y10S435/878

公开(公告)号：EP0192746A4

公开(公告)日：1987-02-12

申请号：EP85904570

申请日：1985-09-11

申请人： SCRIPPS CLINIC RES

发明人： FIELDS PATRICIA I ,  HAIDARIS CONSTANTINE G ,  HEFFRON FREDERICK L

IPC分类号： C12N15/00 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/112 ,  C12N1/10 ,  C12N1/14 ,  C12N1/16 ,  C12N1/19 ,  C12N1/20 ,  C12N15/09 ,  C12N15/90 ,  C12R1/01 ,  C12R1/07 ,  C12R1/145 ,  C12R1/185 ,  C12R1/21 ,  C12R1/22 ,  C12R1/32 ,  C12R1/38 ,  C12R1/42 ,  C12R1/44 ,  C12R1/46 ,  C12R1/645 ,  C12R1/66 ,  C12R1/90 ,  A61K37/00

CPC分类号： A61K39/0002 ,  A61K39/002 ,  A61K39/02 ,  A61K2039/522 ,  C12N15/90 ,  Y10S435/879

摘要： A vaccine against a microbial pathogen comprised of a live, immunogenic but prototrophic and avirulent mutant strain of the selected microbial pathogen in an amount effective to confer immunity. A method of obtaining a vaccine that induces a heightened cellular and humoral immune response to one of a variety of microbial pathogens in a warm blooded animal. A method for isolation of an avirulent strain of a selected pathogenic microorganism.

公开(公告)号：EP4362661A1

公开(公告)日：2024-05-08

申请号：EP22750947.8

申请日：2022-06-30

申请人： Pivot Bio, Inc.

发明人： ESKIYENENTURK, Bilge Ozaydin ,  RYU, Min-Hyung ,  JOHNSON, Jenny ,  WONG, Leland

IPC分类号： A01H3/00 ,  A01N63/20 ,  C07K14/195 ,  C12N1/20 ,  C12N9/02 ,  C12P3/00 ,  C12R1/01 ,  C12R1/22

CPC分类号： A01H3/00 ,  A01N63/20 ,  C07K14/195 ,  C12N1/20 ,  C12N1/205 ,  C12P3/00 ,  C12Y118/06001 ,  C12N9/0095 ,  C12R2001/2220210501 ,  C12R2001/0120210501 ,  A01P21/00

公开(公告)号：EP4143293A1

公开(公告)日：2023-03-08

申请号：EP20727108.1

申请日：2020-05-01

申请人： Pivot Bio, Inc.

发明人： WOOD, Kent ,  BROWN, Russell ,  GAGE, Jeremy ,  RASMUSSEN, Rikke ,  RAINE, Paul ,  BLOCH, Sarah ,  TAMSIR, Alvin ,  TEMME, Karsten ,  ESKIYENENTURK, Bilge Ozaydin

IPC分类号： C12M1/04 ,  A01H4/00 ,  A01H1/00 ,  A01G7/00 ,  A01G9/00 ,  A01G29/00 ,  C07K14/26 ,  C12N1/20 ,  C12N9/12 ,  C12N15/82 ,  C12R1/22

公开(公告)号：EP3193918A1

公开(公告)日：2017-07-26

申请号：EP15841265.0

申请日：2015-09-18

申请人： University of Maryland, Baltimore

发明人： SIMON, Raphael ,  CROSS, Alan ,  TENNANT, Sharon

IPC分类号： A61K39/00 ,  A61K39/104 ,  A61K39/108 ,  C12N1/20 ,  C12N1/21 ,  C12R1/22 ,  C12R1/42

CPC分类号： C07K14/26 ,  A61K39/0266 ,  A61K39/104 ,  A61K39/116 ,  A61K47/4833 ,  A61K47/61 ,  A61K47/646 ,  A61K2039/70 ,  C07K14/21 ,  C07K2319/00

摘要： The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and O12. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

摘要翻译： 本发明涉及缀合物和疫苗组合物，其包含与一种或多种克雷伯氏菌表面多糖抗原（例如来自血清型O1，O2a，O2a，c，O3，O4的肺炎克雷伯菌O多糖）连接的假单胞菌鞭毛蛋白或其抗原片段或衍生物 O5，O7，O8和012.本发明还提供了制备缀合物和疫苗组合物的血清变型试剂菌株以及用缀合物和疫苗组合物诱导免疫应答的方法。

公开(公告)号：EP2657332B1

公开(公告)日：2016-03-09

申请号：EP13177967.0

申请日：2008-03-14

申请人： Ajinomoto Co., Inc.

发明人： Shiraga, Seizaburo ,  Murayama, Noriko ,  Izui, Hiroshi ,  Ito, Hisao ,  Yasueda, Hisashi ,  Usuda, Yoshihiro ,  Matsui, Kazuhiko

IPC分类号： C12N1/21 ,  C12P13/10 ,  C12P13/14 ,  C12P13/24 ,  C12N15/09 ,  C12R1/01 ,  C12R1/15 ,  C12R1/22 ,  C12R1/425 ,  C12N9/02

CPC分类号： C12P13/14 ,  C12N9/0008 ,  C12P13/10 ,  C12P13/24

公开(公告)号：EP2054500A2

公开(公告)日：2009-05-06

申请号：EP07805986.2

申请日：2007-08-16

申请人： Ajinomoto Co., Inc.

发明人： HARA, Yoshihiko ,  IZUI, Hiroshi

IPC分类号： C12N1/00 ,  C12N1/21 ,  C12N15/09 ,  C12P13/14 ,  C12R1/18 ,  C12R1/22

CPC分类号： C12P13/14 ,  C07K14/24 ,  C07K14/26 ,  C07K14/265 ,  C07K14/27

摘要： An L-glutamic acid producing bacterium which belongs to the genus Pantoea, Enterobacter, Klebsiella or Erwinia, wherein the bacterium has been modified by gene recombination to inactivate the rpoS gene, is cultured in a medium to cause accumulation of L-glutamic acid in the medium, and L-glutamic acid is collected from the medium.