公开(公告)号：EP1047690A1

公开(公告)日：2000-11-02

申请号：EP98964167.5

申请日：1998-12-18

申请人： Abbott Laboratories

发明人： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

摘要： Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：EP1198456B1

公开(公告)日：2007-09-19

申请号：EP00955327.2

申请日：2000-08-02

申请人： ABBOTT LABORATORIES

发明人： ALTENBACH, Robert, J. ,  BAI, Hao ,  BRIONI, Jorge, D. ,  CARROLL, William, A. ,  GOPALAKRISHNAN, Murali ,  GREGG, Robert, J. ,  HOLLADAY, Mark, W. ,  HUANG, Peggy, P. ,  KINCAID, John, F. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  PEREZ-MEDRANO, Arturo ,  ZHANG, Henry, Q.

IPC分类号： C07D213/74 ,  C07C335/18 ,  C07C335/16 ,  C07C279/28 ,  C07C279/30 ,  C07D209/08 ,  C07D235/06 ,  C07D401/12 ,  C07D239/42 ,  C07D401/04 ,  C07D233/42 ,  C07D407/12 ,  C07C275/30 ,  C07D215/38 ,  A61K31/47 ,  A61K31/44 ,  A61K31/17 ,  A61K31/155

CPC分类号： C07D213/74 ,  A61K31/17 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07D209/08 ,  C07D215/38 ,  C07D233/42 ,  C07D235/06 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12

摘要： Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP1198456A2

公开(公告)日：2002-04-24

申请号：EP00955327.2

申请日：2000-08-02

申请人： Abbott Laboratories

发明人： ALTENBACH, Robert, J. ,  BAI, Hao ,  BRIONI, Jorge, D. ,  CARROLL, William, A. ,  GOPALAKRISHNAN, Murali ,  GREGG, Robert, J. ,  HOLLADAY, Mark, W. ,  HUANG, Peggy, P. ,  KINCAID, John, F. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  PEREZ-MEDRANO, Arturo ,  ZHANG, Henry, Q.

IPC分类号： C07D213/74

CPC分类号： C07D213/74 ,  A61K31/17 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07D209/08 ,  C07D215/38 ,  C07D233/42 ,  C07D235/06 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12

摘要： Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP1047690B1

公开(公告)日：2004-03-24

申请号：EP98964167.5

申请日：1998-12-18

申请人： Abbott Laboratories

发明人： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

摘要： Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：EP1212319A2

公开(公告)日：2002-06-12

申请号：EP00965070.6

申请日：2000-09-14

申请人： Abbott Laboratories

发明人： LIN, Nan-Horng ,  LI, Yihong ,  DRIZIN, Irene ,  KINCAID, John, F. ,  BASHA, Anwer ,  DONG, Liming ,  HAKEEM, Ahmed, A.

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  A61K31/4427 ,  A61P25/00

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D409/14

摘要： A series of 3-pyrrolidinyloxy-3'-pyridyl ether compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions including these compounds. Preferred compounds are 3-pyrrolidinylmethoxy-3'-(5'-and/or 6'-substituted) pyridyl ethers.