公开(公告)号：EP0717741A1

公开(公告)日：1996-06-26

申请号：EP94931741.0

申请日：1994-08-30

申请人： ABBOTT LABORATORIES

发明人： LIN, Nan-Horng ,  HE, Yun ,  ELLIOTT, Richard, L. ,  CHORGHADE, Mukund, S. ,  WITTENBERGER, Steven, J. ,  BUNNELLE, William, H. ,  NARAYANAN, Bikshandar, A. ,  SINGAM, Pulla R., Apartment 302 ,  ESCH, Thomas, K., J. ,  BEER, Dieter, O. ,  WITZIG, Christian, C. ,  HERZIG, Thomas, C. ,  RAO, Alla, V. Rama, Residence of Director

IPC分类号： C07D413

CPC分类号： C07D413/04

摘要： A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：EP0922050B1

公开(公告)日：2003-07-30

申请号：EP97921411.1

申请日：1997-04-25

申请人： ABBOTT LABORATORIES

发明人： ELLIOTT, Richard, L. ,  OR, Yat, Sun ,  CHU, Daniel, T. ,  GRIESGRABER, George, W. ,  PLATTNER, Jacob, J. ,  PIREH, Daisy

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

公开(公告)号：EP0922050A1

公开(公告)日：1999-06-16

申请号：EP97921411.0

申请日：1997-04-25

申请人： ABBOTT LABORATORIES

发明人： ELLIOTT, Richard, L. ,  OR, Yat, Sun ,  CHU, Daniel, T. ,  GRIESGRABER, George, W. ,  PLATTNER, Jacob, J. ,  PIREH, Daisy

IPC分类号： A61K31 ,  C07H17

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

公开(公告)号：EP0876388B1

公开(公告)日：2004-02-18

申请号：EP96936579.0

申请日：1996-10-17

申请人： Abbott Laboratories

发明人： OR, Yat, Sun ,  PHAN, Ly, Tam ,  CHU, Daniel, T. ,  SPINA, Kenneth, P. ,  HALLAS, Robert ,  ELLIOTT, Richard, L.

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08

公开(公告)号：EP0842178B1

公开(公告)日：2001-03-28

申请号：EP96926133.8

申请日：1996-07-25

申请人： Abbott Laboratories

发明人： ELLIOTT, Richard, L. ,  RYTHER, Keith, B. ,  HOLLADAY, Mark, W. ,  WASICAK, James, T. ,  DAANEN, Jerome, F.

IPC分类号： C07D491/044 ,  C07D519/00 ,  A61K31/435 ,  C07D471/04

CPC分类号： C07D471/04 ,  A61K31/4355 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： Novel heterocyclic ether compounds having the formula (I) wherein A, m, R, X, Y?1, Y2 and Y3¿ are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP0874863A1

公开(公告)日：1998-11-04

申请号：EP96940766.0

申请日：1996-11-06

申请人： ABBOTT LABORATORIES

发明人： OR, Yat, Sun ,  CHU, Daniel, T. ,  ELLIOTT, Richard, L. ,  PIREH, Daisy

IPC分类号： A61K31 ,  A61P31 ,  C07H17

CPC分类号： C07H17/08

摘要： A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R8 are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.

摘要翻译： 选自组（I），（II）和（III）的化合物，其中A，B，V，W，X和R8具体定义; 其药物组合物; 通过给予其治疗有效的药物组合物治疗或预防细菌感染的方法; 及其制备方法。

公开(公告)号：EP0717741B1

公开(公告)日：2001-05-30

申请号：EP94931741.6

申请日：1994-08-30

申请人： ABBOTT LABORATORIES

发明人： LIN, Nan-Horng ,  HE, Yun ,  ELLIOTT, Richard, L. ,  CHORGHADE, Mukund, S. ,  WITTENBERGER, Steven, J. ,  BUNNELLE, William, H. ,  NARAYANAN, Bikshandar, A. ,  SINGAM, Pulla R., Apartment 1116 ,  ESCH, Thomas, K., J. ,  BEER, Dieter, O. ,  WITZIG, Christian, C. ,  HERZIG, Thomas, C. ,  RAO, Alla, V. Rama, Residence of Director

IPC分类号： C07D413/04 ,  C07D207/09

CPC分类号： C07D413/04

摘要： A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：EP1047690A1

公开(公告)日：2000-11-02

申请号：EP98964167.5

申请日：1998-12-18

申请人： Abbott Laboratories

发明人： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

摘要： Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：EP0961776A1

公开(公告)日：1999-12-08

申请号：EP97920261.0

申请日：1997-04-07

申请人： Abbott Laboratories

发明人： OR, Yat, Sun ,  PHAN, Ly, Tam ,  CHU, Daniel, T. ,  SPINA, Kenneth, P. ,  HALLAS, Robert ,  ELLIOTT, Richard, L. ,  TUFANO, Michael

IPC分类号： C07H17 ,  A61K31 ,  A61P31

CPC分类号： C07H17/08 ,  C07H17/00

摘要： Compounds, or pharmaceutically acceptable salts and esters thereof, of formulas: (I); (II); (III); or (IV); wherein A, B, D and E, R1, R2, and Z specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of bacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：EP0876388A1

公开(公告)日：1998-11-11

申请号：EP96936579.0

申请日：1996-10-17

申请人： Abbott Laboratories

发明人： OR, Yat, Sun ,  PHAN, Ly, Tam ,  CHU, Daniel, T. ,  SPINA, Kenneth, P. ,  HALLAS, Robert ,  ELLIOTT, Richard, L.

IPC分类号： C07H17 ,  A61K31 ,  A61P31

CPC分类号： C07H17/08

摘要： Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R1, R2 and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.