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1.发明公开METHOD OF PREPARING ENANTIOMERICALLY-PURE 3-METHYL-5-(1-ALKYL-2(S)-PYRROLIDINYL)ISOXAZOLES 失效用于制备对映体纯的3-甲基-5-（1-烷基-2-（S） - 吡咯烷基）的方法，异恶唑
公开(公告)号：EP0717741A1
公开(公告)日：1996-06-26
申请号：EP94931741.0
申请日：1994-08-30
申请人： ABBOTT LABORATORIES
发明人： LIN, Nan-Horng , HE, Yun , ELLIOTT, Richard, L. , CHORGHADE, Mukund, S. , WITTENBERGER, Steven, J. , BUNNELLE, William, H. , NARAYANAN, Bikshandar, A. , SINGAM, Pulla R., Apartment 302 , ESCH, Thomas, K., J. , BEER, Dieter, O. , WITZIG, Christian, C. , HERZIG, Thomas, C. , RAO, Alla, V. Rama, Residence of Director
IPC分类号： C07D413
CPC分类号： C07D413/04
摘要： A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
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2.发明授权METHOD OF PREPARING ENANTIOMERICALLY-PURE 3-METHYL-5-(1-ALKYL-2(S)-PYRROLIDINYL)ISOXAZOLES 失效用于制备对映体纯的3-甲基-5-（1-烷基-2-（S） - 吡咯烷基）的方法，异恶唑
公开(公告)号：EP0717741B1
公开(公告)日：2001-05-30
申请号：EP94931741.6
申请日：1994-08-30
申请人： ABBOTT LABORATORIES
发明人： LIN, Nan-Horng , HE, Yun , ELLIOTT, Richard, L. , CHORGHADE, Mukund, S. , WITTENBERGER, Steven, J. , BUNNELLE, William, H. , NARAYANAN, Bikshandar, A. , SINGAM, Pulla R., Apartment 1116 , ESCH, Thomas, K., J. , BEER, Dieter, O. , WITZIG, Christian, C. , HERZIG, Thomas, C. , RAO, Alla, V. Rama, Residence of Director
IPC分类号： C07D413/04 , C07D207/09
CPC分类号： C07D413/04
摘要： A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
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3.发明公开HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 有权杂环醚和硫醚类化合物适用于控制化学突触传递
公开(公告)号：EP1047690A1
公开(公告)日：2000-11-02
申请号：EP98964167.5
申请日：1998-12-18
申请人： Abbott Laboratories
发明人： HOLLADAY, Mark, W. , ABREO, Melwyn, A. , GUNN, David, E. , LIN, Nan-Horng , GARVEY, David, S. , RYTHER, Keith , LEBOLD, Suzanne, A. , ELLIOTT, Richard, L. , HE, Yun , WASIAK, James, T. , BAI, Hao , DART, Michael, J. , EHRLICH, Paul, P. , LI, Yihong , KINCAID, John, F. , SCHKERYANTZ, Jeffrey, M. , LYNCH, John, K.
IPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D487/04 , C07D455/02 , A61K31/44 , A61K31/40 , A61K31/425 , A61K31/50 , A61K31/505 , A61K31/47
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04
摘要： Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.
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4.发明公开3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 失效3-吡啶基氧基甲基杂环醚化合物FOR化学突触传递的控制
公开(公告)号：EP0934308A1
公开(公告)日：1999-08-11
申请号：EP97927830.0
申请日：1997-06-04
申请人： Abbott Laboratories
发明人： LIN, Nan-Horng , HE, Yun , HOLLADAY, Mark, W. , RYTHER, Keith , LI, Yihong , BAI, Hao
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： Novel 3-pyridyloxymethyl heterocyclic ether compounds of formula (I) or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula (I) with the variables defined in the specification are also described.
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公开(公告)号：EP0588917A1
公开(公告)日：1994-03-30
申请号：EP92912971.0
申请日：1992-05-28
申请人： ABBOTT LABORATORIES
发明人： GARVEY, David S. , CARRERA, George M., Jr. , ARNERIC, Stephen P. , SHUE, Youe-Kong , LIN, Nan-Horng , HE, Yun
CPC分类号： C07D417/04 , C07D413/04
摘要： Agonistes nicotiniques, sélectifs et puissants, de la formule (I), ou sels pharmaceutiquement acceptables de ceux-ci, utilisés dans le traitement de troubles mentaux, neurologiques et cognitifs caractérisés par une diminution des fonctions cholinergiques.
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6.发明授权3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 失效3-吡啶基氧基甲基杂环醚化合物FOR化学突触传递的控制
公开(公告)号：EP0934308B1
公开(公告)日：2004-08-11
申请号：EP97927830.6
申请日：1997-06-04
申请人： Abbott Laboratories
发明人： LIN, Nan-Horng , HE, Yun , HOLLADAY, Mark, W. , RYTHER, Keith , LI, Yihong , BAI, Hao
IPC分类号： C07D401/12 , C07D401/14 , C07D407/14 , C07D409/14 , A61K31/44 , A61K31/445 , A61K31/465 , A61K31/505
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
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7.发明公开3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 失效3-吡啶氧基杂环醚化合物，用于控制化学突触传递
公开(公告)号：EP0846114A1
公开(公告)日：1998-06-10
申请号：EP96914786.0
申请日：1996-05-28
申请人： Abbott Laboratories
发明人： HOLLADAY, Mark, W. , LIN, Nan-Horng , RYTHER, Keith, B. , HE, Yun
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12
摘要： Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R1, R2, A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.
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8.发明授权HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 有权杂环醚和硫醚类化合物适用于控制化学突触传递
公开(公告)号：EP1047690B1
公开(公告)日：2004-03-24
申请号：EP98964167.5
申请日：1998-12-18
申请人： Abbott Laboratories
发明人： HOLLADAY, Mark, W. , ABREO, Melwyn, A. , GUNN, David, E. , LIN, Nan-Horng , GARVEY, David, S. , RYTHER, Keith , LEBOLD, Suzanne, A. , ELLIOTT, Richard, L. , HE, Yun , WASIAK, James, T. , BAI, Hao , DART, Michael, J. , EHRLICH, Paul, P. , LI, Yihong , KINCAID, John, F. , SCHKERYANTZ, Jeffrey, M. , LYNCH, John, K.
IPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D487/04 , C07D455/02 , A61K31/44 , A61K31/40 , A61K31/425 , A61K31/50 , A61K31/505 , A61K31/47
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04
摘要： Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.
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9.发明授权3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 失效3-吡啶氧基杂环醚化合物，用于控制化学突触传递
公开(公告)号：EP0846114B1
公开(公告)日：2001-12-05
申请号：EP96914786.7
申请日：1996-05-28
申请人： Abbott Laboratories
发明人： HOLLADAY, Mark, W. , LIN, Nan-Horng , RYTHER, Keith, B. , HE, Yun
IPC分类号： C07D401/12 , A61K31/44
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12
摘要： Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R1, R2, A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.
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公开(公告)号：EP0588917B1
公开(公告)日：2000-11-08
申请号：EP92912971.6
申请日：1992-05-28
申请人： ABBOTT LABORATORIES
发明人： GARVEY, David S. , CARRERA, George M., Jr. , ARNERIC, Stephen P. , SHUE, Youe-Kong , LIN, Nan-Horng , HE, Yun
IPC分类号： C07D413/04 , C07D417/04 , A61K31/425 , A61K31/42
CPC分类号： C07D417/04 , C07D413/04
摘要： Selective and potent nicotinic agonists of formula (I), or pharmaceutically-acceptable salts thereof, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.
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