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    DOLASTATIN 15 DERIVATIVES
    1.
    发明公开
    DOLASTATIN 15 DERIVATIVES 审中-公开
    多拉司他汀15个衍生物

    公开(公告)号：EP1093460A1

    公开(公告)日：2001-04-25

    申请号：EP99930569.1

    申请日：1999-06-23

    申请人： BASF AKTIENGESELLSCHAFT ,  BASF Bioresearch Corporation

    发明人： RITTER, Kurt ,  JANSSEN, Bernd ,  HAUPT, Andreas ,  KLING, Andreas ,  BARLOZZARI, Teresa ,  AMBERG, Wilhelm

    IPC分类号： C07K7/02 ,  C07K5/103 ,  C07K5/117 ,  A61K38/07 ,  A61K38/08

    CPC分类号： C07K7/02 ,  A61K38/00 ,  C07K5/101 ,  C07K5/1024

    摘要： Compounds of the present invention include cell growth inhibitors which are peptides of Formula (I): A - B - D - E - F - G and acid salts thereof, wherein A, D and E are α-amino acid residues, B is an α-amino acid residue or an α-hydroxy acid residue, F is an aminobenzoic acid residue or an aminocycloalkanecarboxylic acid residue, and G is a monovalent radical, such as, for example, a hydrogen atom, an amino group, an alkyl group, an alkylene alkyl ether, an alkylene alkyl thioether, an alkylene aldehyde, an alkylene amide, a β-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, an oximato group, an alkylene aryl group, an alkylene ester, an alkylene sulfoxide or an alkylene sulfone. Another aspect of the present invention includes pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable carrier. An additional embodiment of the present invention is a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula (I) in a pharmaceutically acceptable composition.

    DOLASTATIN 15 DERIVATIVES
    3.
    发明公开
    DOLASTATIN 15 DERIVATIVES 失效
    DOLASTATIN 15 DERIVATE

    公开(公告)号：EP0991658A1

    公开(公告)日：2000-04-12

    申请号：EP98935531.8

    申请日：1998-07-07

    申请人： BASF AKTIENGESELLSCHAFT

    发明人： JANSSEN, Bernd ,  BARLOZZARI, Teresa ,  HAUPT, Andreas ,  ZIERKE, Thomas ,  KLING, Andreas

    IPC分类号： C07K7/06 ,  A61K38/08

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C12P19/34

    摘要： Compounds of the present invention include cell growth inhibitors which are peptides of Formula (I):, A - B - D - E - F - (G)r - (K)s - L and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a β-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula (I) in a pharmaceutically acceptable composition.