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公开(公告)号：EP0804463A1
公开(公告)日：1997-11-05
申请号：EP95919392.0
申请日：1995-05-04
发明人： SCHNORRENBERG, Gerd , ESSER, Franz , DOLLINGER, Horst , JUNG, Birgit , SPECK, Georg , BUERGER, Erich
CPC分类号： C07K5/06165 , A61K38/00 , C07K5/06139 , C07K5/0821
摘要： The invention concerns new amino acid derivatives of general formula (I): R?1-R11-A1¿-B, and pharmaceutically acceptable salts thereof, wherein the group B represents -A?2- NR2R3 or R5, R1, A1, A2, R2, R3, R5 and R11¿ having the meanings indicated in the description. The invention also concerns the production and use of these compounds. The new compounds are valuable neurokinine (tachykinine) antagonists.
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2.发明公开
公开(公告)号：EP0802922A1
公开(公告)日：1997-10-29
申请号：EP95909796.0
申请日：1995-03-02
发明人： ESSER, Franz , SCHNORRENBERG, Gerd , DOLLINGER, Horst , JUNG, Birgit , BUERGER, Erich , SPECK, Georg
CPC分类号： C07D215/38 , A61K38/00 , C07D401/14 , C07D491/04 , C07K5/0202 , C07K5/06139 , C07K5/06165
摘要： The invention concerns novel amino acid derivatives of general formula (I) and their pharmaceutically acceptable salts, in which the R2 group is (II) and R1, A, G, Y, Z and m have the meanings given in the description, and their production and use. The novel compounds are valuable neurokinin (tachykinin) antagonists.
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3.发明公开SUBSTITUIERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ]NDLICHEN ERKRANKUNGEN 审中-公开SUTITANTERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ] NDLICHEN ERKRANKUNGEN
公开(公告)号：EP1824854A2
公开(公告)日：2007-08-29
申请号：EP05823962.5
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, joint, skin or eye inflammatory diseases, disease of the periphery or central nervous system or cancer. The invention also relates to pharmaceutical compositions containing said compounds.
摘要翻译： 本发明涉及适用于治疗呼吸或胃肠疾病，关节，皮肤或眼睛炎性疾病，外周或中枢神经系统疾病或癌症的新型蝶啶。 本发明还涉及含有所述化合物的药物组合物。
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公开(公告)号：EP1819708A2
公开(公告)日：2007-08-22
申请号：EP05849039.2
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines which can be used in the treatment of respiratory or gastrointestinal complaints or diseases, joint, skin or eye inflammatory diseases, diseases of the periphery or central nervous system or cancer. The invention also relates to pharmaceutical compositions which contain said compounds.
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公开(公告)号：EP2417120A1
公开(公告)日：2012-02-15
申请号：EP10712432.3
申请日：2010-04-01
发明人： GRUNDL, Marc , DOLLINGER, Horst , GIOVANNINI, Riccardo , HOENKE, Christoph , HOFFMANN, Matthias , KRIEGL, Jan , MARTYRES, Domnic , RAST, Georg , SEITHER, Peter
IPC分类号： C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/4523 , A61K31/454 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： C07D401/04 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/5355 , A61K31/56 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： Object of the present invention are novel substituted compounds of the formula 1, wherein A, R
1 , R
2 , R
3 and R
4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.-
公开(公告)号：EP2215092A1
公开(公告)日：2010-08-11
申请号：EP08839793.0
申请日：2008-10-16
发明人： POUZET, Pascale , ANDERSKEWITZ, Ralf , DOLLINGER, Horst , FIEGEN, Dennis , FOX, Thomas , GOEGGEL, Rolf , HOENKE, Christoph , MARTYRES, Domnic , NICKOLAUS, Peter , KLINDER, Klaus
IPC分类号： C07D495/04 , C07D519/00 , A61K31/519 , A61P11/00
CPC分类号： C07D495/04 , C07D519/00
摘要： The invention relates to the novel piperidino-dihydrothienopyrimidines of formula (I) and to the pharmacologically acceptable salts thereof, wherein X represents SO or SO2, preferably however SO, and wherein R1, R2, R3 and R4 are defined as in claim 1. The invention also relates to pharmaceutical compositions containing said compounds. The novel piperidino-dihydrothienopyrimidines are suitable for use in the treatment of respiratory or gastrointestinal disorders or diseases, inflammatory diseases of the joints, the skin or the eyes, diseases of the peripheral or central nervous system or cancers.
摘要翻译： 本发明涉及式（I）的新的哌啶子基 - 二氢噻吩并嘧啶及其药理学可接受的盐，其中X代表SO或SO 2，然而优选SO，并且其中R 1，R 2，R 3和R 4如权利要求1中所定义。 本发明还涉及含有所述化合物的药物组合物。 新的哌啶子基 - 二氢噻吩并嘧啶适用于治疗呼吸系统或胃肠疾病或疾病，关节炎症，皮肤或眼睛，外周或中枢神经系统疾病或癌症。
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7.发明公开
公开(公告)号：EP2205609A2
公开(公告)日：2010-07-14
申请号：EP08840075.9
申请日：2008-10-16
发明人： POUZET, Pascale , ANDERSKEWITZ, Ralf , DOLLINGER, Horst , FIEGEN, Dennis , FOX, Thomas , GOEGGEL, Rolf , HOENKE, Christoph , MARTYRES, Domnic , NICKOLAUS, Peter , KLINDER, Klaus
IPC分类号： C07D495/04 , C07D519/00 , A61K31/519 , A61P1/00 , A61P11/00 , A61P25/00
CPC分类号： C07D495/04 , A61K31/519 , A61K2300/00
摘要： The invention relates to the novel dihydrothienopyrimidine sulfoxides of formula (I) and to the pharmacologically acceptable salts thereof, wherein X represents SO or SO2, preferably however SO, and wherein R3 represents an optionally substituted, monocyclic or bicyclic, unsaturated, partially saturated or saturated heterocycle or an optionally substituted, monocyclic or bicyclic heteroaryl, and wherein R1 and R2 are defined as in claim 1. The invention also relates to pharmaceutical compositions containing said compounds. The novel dihydrothienopyrimidine sulfoxides are suitable for use in the treatment of respiratory or gastrointestinal disorders or diseases, inflammatory diseases of the joints, the skin or the eyes, diseases of the peripheral or central nervous system or cancers.
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8.发明公开VERWENDUNG VON SUBSTITUIERTEN PTERIDINEN ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN 审中-公开取代蝶啶类的呼吸系统疾病治疗中的应用
公开(公告)号：EP1708715A1
公开(公告)日：2006-10-11
申请号：EP05700802.1
申请日：2005-01-11
发明人： NICKOLAUS, Peter , MEADE, Christopher J. Montague , DOLLINGER, Horst , MACK, Jürgen , DAHMANN, Georg , MARTYRES, Domnic , JUNG, Birgit
IPC分类号： A61K31/519 , A61P11/00 , A61P11/06
CPC分类号： A61K31/525 , A61K31/519 , A61K31/5377 , A61K31/541
摘要： The invention relates to the use of pteridines for the treatment of inflammatory and obstructive diseases of the respiratory tract, preferably asthma or COPD, and pharmaceutical compounds containing said compounds.
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9.发明公开
公开(公告)号：EP1648888A1
公开(公告)日：2006-04-26
申请号：EP04740684.8
申请日：2004-07-06
发明人： ANDERSKEWITZ, Ralf , BIRKE, Franz , BOUYSSOU, Thierry , DOLLINGER, Horst , MARTYRES, Domnic , POUZET, Pascale, Arielle, Jane-Josee
IPC分类号： C07D451/02 , A61K31/46 , A61P29/00
CPC分类号： C07D451/04 , A61K31/46 , Y02A50/465 , A61K2300/00
摘要： Use of a compound of general formula 1 for manufacturing a medicament to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, in particular compounds of formula 1: wherein R , R , R , A, B, X, W, Z, i, j, k, l and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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10.发明授权
公开(公告)号：EP0802922B1
公开(公告)日：2001-09-26
申请号：EP95909796.5
申请日：1995-03-02
发明人： ESSER, Franz , SCHNORRENBERG, Gerd , DOLLINGER, Horst , JUNG, Birgit , BUERGER, Erich , SPECK, Georg
CPC分类号： C07D215/38 , A61K38/00 , C07D401/14 , C07D491/04 , C07K5/0202 , C07K5/06139 , C07K5/06165
摘要： The invention concerns novel amino acid derivatives of general formula (I) and their pharmaceutically acceptable salts, in which the R2 group is (II) and R1, A, G, Y, Z and m have the meanings given in the description, and their production and use. The novel compounds are valuable neurokinin (tachykinin) antagonists.
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